Results 101 to 110 of about 32,964 (245)
Alzheimer’s Research & TherapyBackground Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD).
Dan Cheng +5 more
doaj +1 more source
Low-PAPR ASE-DMT Using Constellation Extension for Optical Wireless Communications
SensorsIn the realm of optical wireless communication (OWC), augmented spectral efficiency discrete multitone (ASE-DMT) has been widely recognized as a promising modulation due to its outstanding spectral efficiency and high power efficiency.
Yue Wu, Yiding Li, Baolong Li
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Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
British Journal of Clinical Pharmacology, EarlyView.Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
Exploring new avenues: Psychedelic‐assisted therapy for young people
British Journal of Clinical Pharmacology, EarlyView.Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou +3 more
wiley +1 more source
Frontiers in PsychologyIntroductionClassical near-death experiences (NDEs) refer to states of disconnected consciousness characterised by a range of features occurring in the context of being close to death. Various psychedelic substances, such as N,N-dimethyltryptamine (DMT),
Pascal Michael +3 more
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Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker
Chemistry – A European Journal, EarlyView.ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo +2 more
wiley +1 more source
Pharmacology and Therapeutic Potential of N,N-Dimethyltryptamine: Ischemia-Related Application
This thesis explores the therapeutic potential of N,N-Dimethyltryptamine (DMT), a naturally occurring psychedelic compound known for its intense but short-lasting psychoactive effects.
Aghapour Olilo, Benyamin
core
Fluorogenic Sydnones for Bioorthogonal Labeling of DNA
Chemistry – A European Journal, EarlyView.Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller +1 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.An electrophilic 5‐isothiocyanatomethyl uridine building block enables modular post‐synthetic RNA labeling with primary amine‐containing probes. Positioning the functionality in the major groove minimizes structural perturbation and allows facile conjugation of sensitive tags such as TEMPO spin labels for paramagnetic relaxation enhancement studies ...
Lisa Ruetz +4 more
wiley +1 more source
Sum-rate maximisation comparison using incremental approaches with different constraints [PDF]
, 2009 In this work, the problem of rate maximisation of multichannel systems is considered. Two greedy allocation approaches using power (GPA) and bit (GBA) loading schemes with a slight difference in design constraints that aiming to maximise the overall ...
Al-Hanafy, Waleed, Weiss, S.
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