Results 181 to 190 of about 3,376,191 (316)

NapR, a novel nucleoid-associated protein, regulates antioxidant defense in mycobacteria. [PDF]

mSphere
Wang K, Cui X, Zhang X, Zheng J, Ling X, Zhang Y, Yu P, Lv B, Li W.   +8 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

RAD51 D-loop structures reveal the mechanism of eukaryotic RAD51-mediated strand exchange. [PDF]

Nat Commun
Luo SC, Yang CH, Yeh HY, Lin CW, Yeh MC, Chi P, Ho MC.   +6 more
europepmc   +1 more source

Synthesis of DNA complementary to separated human alpha and beta globin messenger RNAs.

Proceedings of the National Academy of Sciences of the United States of America, 1975
B. Forget, D. Housman, E. Benz, R. Mccaffrey   +3 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The effect of PEGylation on surface tethering of liposomes via DNA nanotechnology. [PDF]

J Lipid Res
Gaston JP, Meepat S, Islam MS, Li J, Daljit Singh JK, Booth MJ, Wickham SF, Baker MA.   +7 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Simple in vitro single-stranded linear and circular DNA preparation, functional selection, and validation using phosphor-derived modifications. [PDF]

J Biol Chem
Hamidi SV, Aguilar-Sánchez V, Héroux VL, Perreault J.   +3 more
europepmc   +1 more source

Elongation of DNA complementary to the 5' end of the avian sarcoma virus genome by the virion-associated RNA-dependent DNA polymerase

Journal of Virology, 1979
U. Novak, R. Friedrich, K. Moelling
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source