Results 131 to 140 of about 860,536 (318)

A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast [PDF]

, 2008
The association between transcription and DNA repair is acknowledged as a player in the generation of mutations in a non-random fashion in prokaryotes and eukaryotes.
Leonid Brodsky, Yefim Ronin, Abraham Korol, Eviatar Nevo, Aviv de Morgan, Yechezkel Kashi   +5 more
core   +1 more source

DNA yield and quality of saliva samples and suitability for large scale epidemiological studies in children [PDF]

, 2011
Objective: To evaluate two saliva collection methods for DNA yield and quality as applied to a large, integrated, multicentre, European project involving the collection of biological material from children.
Bailey, Mark E.S., Koni, Anna C., Y P Pitsiladis, J Peplies, Scott, Robert A., G Wang, Wang, G., Bailey, M.E.S., K Bammann, Wang, Guan; id_orcid, Scott, R.A., Peplies, J., Pitsiladis, Y.P., R A Scott, A C Koni, null null, Bammann, K., Pitsiladis, Yannis; id_orcid, Koni, A.C., M E S Bailey   +19 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

DNA methods for the detection of Phytophthora cinnamomi from soil [PDF]

, 2006
This project assesses two aspects of DNA detection of Phytophthora species from soil samples. Firstly, a nested PCR protocol was established with both primary and nested PCR specific for P. cinnamomi detection. PCR amplification of P.
Anderson, Nari Michelle
core   +1 more source

Optimizing Environmental DNA Metabarcoding of Archived Suspended Particulate Matter for River Biodiversity Monitoring [PDF]

Environmental DNA (eDNA) metabarcoding has become a prominent method in aquatic biodiversity research and monitoring. A widely underexplored sample type is suspended particulate matter (SPM), composed of small organic and inorganic particles that contain
Keiichi Fukaya, Till‐Hendrik Macher, Macher, Till‐Hendrik, Fukaya, Keiichi, Florian Leese, Lenz, Ann‐Christin, Arne J. Beermann, Diaz Navarrete, Cecilia Andrea, Cecilia Díaz, Robin Schütz, Ann‐Christin Lenz, Koschorreck, Jan, Schütz, Robin, Leese, Florian, Beermann, Arne J., Jan Koschorreck   +15 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A quantitative analysis of vertebrate environmental DNA degradation in soil in response to time, UV light, and temperature

Environmental DNA
Environmental DNA (eDNA) degradation influences the effectiveness of eDNA‐based biodiversity monitoring, but the factors that determine the rate of decay of eDNA in terrestrial environments are poorly understood. We assessed the persistence of vertebrate
Austin M. Guthrie, Christine E. Cooper, Philip W. Bateman, Mieke van derHeyde, Morten E. Allentoft, Paul Nevill   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Developing an eDNA approach for wetland biomonitoring: Insights on technical and conventional approaches [PDF]

Wetlands are ecologically and culturally significant ecosystems that are experiencing biodiversity declines globally. Biomonitoring techniques that use environmental DNA (eDNA) to detect and monitor biodiversity are well established in lake, riverine ...
Dutton, Paul, Bird, Starsha, Wilkinson, Shaun P., McGaughran, Angela, Duggan, Ian C., Smith, Joshua   +5 more
core   +1 more source