Results 121 to 130 of about 117,531 (301)
SGR3979, SCO7222, and SGR6912 display different DNA protection patterns on the cognate intergenic DNAs. [PDF]
, 2012 DNaseI footprinting assays showing the protection patterns of (A) SGR3979 on the entire SGR3978/SGR3979 intergenic sequence; (B) SCO7222 on the entire SCO7222/SCO7223 intergenic sequence; and (C) SGR6912 on the IGR6912 sequence containing the partial ...
Leslie Cuthbertson (114147) +2 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen +14 more
wiley +1 more source
IBV : potential as a vaccine vector and identification of a novel subgenomic mRNA [PDF]
Using an IBV reverse genetics system a series of recombinant viruses were generated to investigate the potential for utilizing IBV as a vaccine vector.
Bentley, Kirsten
core
With Genes like that who needs an Environment? Postgenomics' argument for the 'Ontogeny of Information' [PDF]
, 2005 The linear sequence specification of a gene product is not provided by the target DNA sequence alone but by the mechanisms of gene expressions. The main actors of these mechanisms, proteins and functional RNAs, relay environmental information to the ...
Stotz, Karola
core
Stable and Functional Regulatory T Cells for Adoptive Cell Therapy
Barrier Immunity, EarlyView.Deprivation of CD28 signaling combined with CDK8/19 inhibition induces stable iTregs with demethylation of Treg‐DRs. Re‐stimulation of these iTregs with additional agents further enhances their suppressive function. The generated S/F‐iTregs suppress inflammation in vivo, and subset of the suppressed Tconvs is converted into de novo pTregs, contributing
Norihisa Mikami
wiley +1 more source
Prokaryotic metallothionein locus and cadmium tolerance in Synechococcus PCC 6301 [PDF]
, 1992 The aim of this study was to investigate the molecular mechanism of Cd-tolerance in the cyanobacterium Synechococcus PCC 6301 and to establish whether the prokaryotic metallothionein (MT) locus, smt, is involved.
Gupta, Amit, Gupta, A
core
Insertion/deletion and nucleotide polymorphism data reveal constraints in Drosophila melanogaster introns and intergenic regions [PDF]
, 2005 Our study of nucleotide sequence and insertion/deletion polymorphism in Drosophila melanogaster noncoding DNA provides evidence for selective pressures in both intergenic regions and introns (of the large size class).
Stephan, W. +5 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley +1 more source
Beni-Suef University Journal of Basic and Applied SciencesBackground Dehaasia pugerensis Koord. & Valeton is an endemic plant species classified as critically endangered (CR) in Jember, Java. It thrives in arid, rocky forest regions, making it a significant genetic resource for plant conservation initiatives ...
Aulia Hasan Widjaya +6 more
doaj +1 more source
A 5 kb intergenic region containing oril in the mitochondrial DNA of Saccharomyces cerevisiae is dispensable for expression of the respiratory phenotype [PDF]
, 1988 A mutant mitochondrial DNA of Saccharomyces cerevisiae strain R 0.54 has been shown to have a 5 kb deletion which removes the oril sequence and its surrounding intergenic sequences between the pro tRNA and 15 S rRNA genes.
Jure Piškur, Piškur, Jure
core +1 more source