Results 111 to 120 of about 117,531 (301)

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Study and Physical Mapping of the Species-Specific Tandem Repeat CS-237 Linked with 45S Ribosomal DNA Intergenic Spacer in Cannabis sativa L. [PDF]

Plants (Basel), 2022
Alexandrov OS, Romanov DV, Divashuk MG, Razumova OV, Ulyanov DS, Karlov GI.   +5 more
europepmc   +1 more source

Evolution of repetitive DNA in angiosperms: examples from Nicotiana allopolyploids [PDF]

, 2012
PhDAllopolyploidy, interspecific hybridisation coupled with genome multiplication, is a prevailing force in the evolution of angiosperms. This thesis examines the consequences of allopolyploidy at the genomic level.
Renny-Byfield, Simon
core  

Minimizing Off‐Target Effects of CRISPR‐Cas9 With Optimized sgRNA: Evaluation of Efficiency and Specificity in the Tumor Protein 53 (TP53) Region

Biotechnology and Bioengineering, EarlyView.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) – Cas9‐based genome editing has emerged as a widely used tool across various disciplines, ranging from molecular biology to gene therapy. This revolutionary technology, which enables precise gene editing, represents a significant advancement in biotechnology, opening new frontiers for ...
Ali Mertcan Köse, Monia Ranalli, Drenka Trivanovic, Irina Maslovaric   +3 more
wiley   +1 more source

Geographic Differences in Genetic Locus Linkages for Borrelia burgdorferi

Emerging Infectious Diseases, 2010
Borrelia burdorferi genotype in the northeastern United States is associated with Lyme borreliosis severity. Analysis of DNA sequences of the outer surface protein C gene and rrs-rrlA intergenic spacer from extracts of Ixodes spp.
Bridgit Travinsky, Jonas Bunikis, Alan G. Barbour   +2 more
doaj   +1 more source

Benchmarking tools for the alignment of functional noncoding DNA [PDF]

, 2004
Pollard DA, Bergman CM, Stoye J, Celniker SE, Eisen MB. Benchmarking tools for the alignment of functional noncoding DNA. BMC Bioinformatics. 2004;5(1): 6.Background: Numerous tools have been developed to align genomic sequences.
Celniker SE, Eisen MB, MB Eisen, Stoye J, Bergman CM, Celniker, Susan E., Bergman, Casey M., SE Celniker, Pollard, Daniel A., Pollard DA, CM Bergman, Eisen, Michael B., J Stoye, Stoye, Jens, Stoye, Jens ; https://orcid.org/, DA Pollard   +15 more
core   +2 more sources

Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris

Biological Diversity, EarlyView.
Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu, Jia Li, Xin Liu, Xue‐Jun Ge, Hui‐Run Huang   +4 more
wiley   +1 more source

A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis

Nature Communications
In plants, the plant-specific RNA polymerase V (Pol V) transcripts non-coding RNAs and provides a docking platform for the association of accessory proteins in the RNA-directed DNA methylation (RdDM) pathway.
Yujuan Liu, Jie Shu, Zhi Zhang, Ning Ding, Jinyuan Liu, Jun Liu, Yuhai Cui, Changhu Wang, Chen Chen   +8 more
doaj   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Molecular characterisation of the intergenic regions of banana bunchy top virus [PDF]

, 2006
Banana bunchy top virus (BBTV) is a circular, single-stranded (css) DNA virus that belongs to the genus Babuvirus in the family Nanoviridae. BBTV is responsible for the most devastating virus disease of banana known as "bunchy top", for which ...
Herrera-Valencia, Virginia Aurora
core