Results 131 to 140 of about 117,531 (301)

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

Intrinsic bent DNA sites in the chromosomal replication origin of Xylella fastidiosa 9a5c

Brazilian Journal of Medical and Biological Research, 2008
The features of the nucleotide sequences in both replication and promoter regions have been investigated in many organisms. Intrinsically bent DNA sites associated with transcription have been described in several prokaryotic organisms.
F. Gimenes, F. de S. Gouveia, A. Fiorini, M.A. Fernandez   +3 more
doaj  

Rapid turnover of long noncoding RNAs and the evolution of gene expression.

PLoS Genetics, 2012
A large proportion of functional sequence within mammalian genomes falls outside protein-coding exons and can be transcribed into long RNAs. However, the roles in mammalian biology of long noncoding RNA (lncRNA) are not well understood.
Claudia Kutter, Stephen Watt, Klara Stefflova, Michael D Wilson, Angela Goncalves, Chris P Ponting, Duncan T Odom, Ana C Marques   +7 more
doaj   +1 more source

Biogeography and diversification patterns in the Irano‐Turanian biodiversity hotspots inferred from a molecular phylogeny of the subendemic Iris subgenus Scorpiris (Iridaceae)

Nordic Journal of Botany, EarlyView.
The Irano‐Turanian Floristic Region harbors a rich flora, but our understanding of the development of this diversity is limited by a lack of data on phylogenetic relationships and biogeographic patterns of endemic and more widespread plants. Hypotheses of in situ diversification versus allopatric diversification were tested using Iris subgen. Scorpiris,
Mona Salimbahrami, Hojjatollah Saeidi, Ali Bagheri, Carol A. Wilson, Gerald M. Schneeweiss   +4 more
wiley   +1 more source

A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children

Clinical Epigenetics
Background/objective There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emerging as an important factor impacting health, but mechanisms need to be uncovered.
Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale   +26 more
doaj   +1 more source

Genetic analysis of the rare forest bryophyte Dicranum viride in the boreo‐nemoral zone near the northern distribution range limit

Nordic Journal of Botany, EarlyView.
Bryophytes are important forest ecosystem elements, being an integral part of biodiversity. Genetic studies contribute to bryophyte population ecology by helping to understand species historical distribution patterns and genetic diversity at different scales.
Anna Mežaka, Ilona Plaksenkova, Līga Anna Leitāne, Baiba Krivmane, Vilnis Šķipars, Dainis Ruņģis   +5 more
wiley   +1 more source

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]

, 2011
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Masayo Arizono, Fumitoshi Hirayama, Hidetoshi Arima, Haruna Ikeda, Tomoko Takeuchi, Kaneto Uekama, Taishi Higashi, Ayumi Yoshimitsu, Kenjiro Hattori, Keiichi Motoyama   +9 more
core   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

Dataset on intergenic spacer regions of chloroplast genome and potential DNA barcode of Hoya varticillata var varticillata in Vietnam

Data in Brief
Hoya verticillata var verticillata, an epiphytic plant, is both an ornamental and a valuable medicinal plant. However, H. verticillata has a similar morphology to other species belonging to the Hoya genus, so it is challenging to distinguish the H ...
Cuong Viet Hoang, Tan Quang Tu, Thu Thi Mai Lo, Mau Hoang Chu   +3 more
doaj   +1 more source