Results 41 to 50 of about 171,193 (280)

The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer

Clinical Epigenetics, 2018
Background DNA methylation is a key epigenetic mark in mammalian organisms that plays key roles in chromatin organization and gene expression. Although DNA methylation in gene promoters is generally associated with gene repression, recent studies ...
Saigopal Somasundaram, Megan E Forrest, Helen Moinova, Allison Cohen, Vinay Varadan, Thomas LaFramboise, Sanford Markowitz, Ahmad M Khalil   +7 more
doaj   +1 more source

In Planta Deletion of DNA Inserts from the Large Intergenic Region of Cauliflower Mosaic Virus DNA [PDF]

Virology, 1993
RNA splicing and copy-choice recombination lead to deletions in the DNA of cauliflower mosaic virus (CaMV). To assess the relative importance of these mechanisms of nucleotide sequence change, free of constraints imposed by the "relay race" mode of translation of CaMV RNA, we examined the stability of inserts in the large intergenic region.
R E, Pennington, U, Melcher
openaire   +2 more sources

Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences

BMC Genomics, 2011
Background DNA methylation has been linked to genome regulation and dysregulation in health and disease respectively, and methods for characterizing genomic DNA methylation patterns are rapidly emerging.
De Marzo Angelo M, Zheng Qizhi, Carvalho Benilton, Morgan James D, He Tony L, Badrinath Raghav, Aryee Martin J, Esopi David, Haffner Michael C, Wu Zhijin, Yegnasubramanian Srinivasan, Irizarry Rafael A, Nelson William G   +12 more
doaj   +1 more source

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain [PDF]

, 2019
The human pathogen Acinetobacter baumannii possesses high genetic plasticity and frequently acquires antimicrobial resistance genes. Here we investigated the role of natural transformation in these processes. Genomic DNA from different sources, including
Bahiense, Camila dos Santos, Bonomo, Robert A., Dotto, Cristian Marcelo, Fernandez, Jennifer, Iriarte, Andres, Melano, Roberto Gustavo, Montaña, Sabrina Daiana, Perez, Federico, Place, Kori, Ramirez, Maria Soledad, Soler Bistue, Alfonso J. C., Tolmasky, Marcelo E., Traglia, German Matias   +12 more
core   +1 more source

Intergenic Breakpoints Identified by DNA Sequencing Confound Targetable Kinase Fusion Detection in NSCLC [PDF]

Journal of Thoracic Oncology, 2020
Next-generation sequencing (NGS) based on genomic DNA has been widely applied for gene rearrangement detection in patients with NSCLC. However, intergenic-breakpoint fusions, in which one or both genomic breakpoints localize to intergenic regions, confound kinase fusion detection.
Weihua, Li, Yutao, Liu, Wenbin, Li, Li, Chen, Jianming, Ying   +4 more
openaire   +2 more sources

Transcription-related mutations and GC content drive variation in nucleotide substitution rates across the genomes of Arabidopsis thaliana and Arabidopsis lyrata

BMC Evolutionary Biology, 2007
Background There has been remarkably little study of nucleotide substitution rate variation among plant nuclear genes, in part because orthology is difficult to establish. Orthology is even more problematic for intergenic regions of plant nuclear genomes,
Gaut Brandon S, DeRose-Wilson Leah J
doaj   +1 more source

RNAi dependent epigenetic marks on a geminivirus promoter

Virology Journal, 2006
Nicotiana benthamiana plants were stably transformed with an intron-spliced dsRNA producing construct cognate to bidirectional promoter of African cassava mosaic geminivirus (ACMV) DNA A.
Dogar Afzal
doaj   +1 more source

Intergenic and genic sequence lengths have opposite relationships with respect to gene expression. [PDF]

PLoS ONE, 2008
Eukaryotic genomes are mostly composed of noncoding DNA whose role is still poorly understood. Studies in several organisms have shown correlations between the length of the intergenic and genic sequences of a gene and the expression of its corresponding
Juliette Colinas, Scott C Schmidler, Gil Bohrer, Borislav Iordanov, Philip N Benfey   +4 more
doaj   +1 more source

A comprehensive microsatellite landscape of human Y-DNA at kilobase resolution

BMC Genomics, 2021
Background Though interest in human simple sequence repeats (SSRs) is increasing, little is known about the exact distributional features of numerous SSRs in human Y-DNA at chromosomal level. Herein, totally 540 maps were established, which could clearly
Douyue Li, Saichao Pan, Hongxi Zhang, Yongzhuo Fu, Zhuli Peng, Liang Zhang, Shan Peng, Fei Xu, Hanrou Huang, Ruixue Shi, Heping Zheng, Yousong Peng, Zhongyang Tan   +12 more
doaj   +1 more source

Genetic determinants of cortical structure (thickness, surface area and volumes) among disease free adults in the CHARGE Consortium [PDF]

, 2019
Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases.
Adams, H., Ahmad, S., Ames, D., Amin, N., Amouye, P., Andreassen, O., Armstrong, N., Bastin, M., Becker, J., Beiser, A., Bernard, M., Beyer, F., Bis, J., Bralten, J., Brodaty, H., Bülow, R., Carmichael, O., Colodro-Conde, L., Crivello, F., Dale, A., Deary, I., Debette, S., DeCarli, C., Fornage, M., Franz, C., Gillespie, N., Grabe, H., Grasby, K., Harris, M., Hibar, D., Himali, J., Hofer, E., Hofman, A., Ikram, M., Jahanshad, N., Jian, X., Jiang, J., Karama, S., Knol, M., Kremen, W., Kwok, J., Lewis, L., Li, S., Lin, H., Lind, P., Loeffler, M., Logue, M., Longstreth Jr., W., Lopez, O., Luciano, M., Lyons, M., Maillard, P., Maingault, S., Mather, K., Mazoyer, B., Medland, S., Mishra, A., Mosley, T., Neale, M., Niessen, W., Painter, J., Panizzon, M., Paus, T., Pausova, Z., Pike, G., Pirpamer, L., Pizzagalli, F., Psaty, B., Roshchupkin, G., Rotter, J., Saba, Y., Sachdev, P., Satizabal, C., Schmid, R., Schmidt, H., Schofield, P., Scholz, M., Seiler, S., Seshadr, S., Stein, J., Teumer, A., Thalamuthu, A., Thompson, P., Trollor, J., Tzourio, C., Uitterlinden, A., van der Lee, S., van Duijn, C., Vernooij, M., Villringer, A., Völker, U., Wardlaw, J., Wen, W., Witte, A., Wittfeld, K., Wright, M., Xia, R., Yang, Q., Zare, H.   +98 more
core   +2 more sources