Results 31 to 40 of about 3,128,275 (354)

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]

, 2018
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés, Pérez de Camino Cantos, Dolores, Silva, Sonia   +2 more
core   +1 more source

Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers.

Proceedings of the National Academy of Sciences of the United States of America, 1989
With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify homologous segments of mtDNA from more than 100 animal species, including mammals, birds, amphibians, fishes, and some invertebrates ...
T. Kocher, W. Thomas, A. Meyer, S. Edwards, S. Pääbo, F. Villablanca, A. Wilson   +6 more
semanticscholar   +1 more source

Mitochondrial DNA sequencing of a wet-collection syntype demonstrates the importance of type material as genetic resource for lantern shark taxonomy (Chondrichthyes: Etmopteridae)

Royal Society Open Science, 2021
After initial detection of target archival DNA of a 116-year-old syntype specimen of the smooth lantern shark, Etmopterus pusillus, in a single-stranded DNA library, we shotgun-sequenced additional 9 million reads from this same DNA library.
Nicolas Straube, Michaela Preick, Gavin J. P. Naylor, Michael Hofreiter   +3 more
doaj   +1 more source

Mitochondrial DNA and disease [PDF]

The Journal of Pathology, 2011
AbstractMitochondrial DNA (mtDNA) defects are a relatively common cause of inherited disease and have been implicated in both ageing and cancer. MtDNA encodes essential subunits of the mitochondrial respiratory chain and defects result in impaired oxidative phosphorylation (OXPHOS).
Robert W. Taylor, Amy K. Reeve, Laura C. Greaves, Douglass M. Turnbull   +3 more
openaire   +3 more sources

DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging

Journal of Aging Research, 2011
During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
Ricardo Gredilla
doaj   +1 more source

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?

Cells, 2022
Mitochondria are well known as ‘the powerhouses of the cell’. Indeed, their major role is cellular energy production driven by both mitochondrial and nuclear DNA.
Amira Podolak, Izabela Woclawek-Potocka, Krzysztof Lukaszuk   +2 more
doaj   +1 more source

Mitochondrial DNA and disease

Annals of Medicine, 2005
The small circle of mitochondrial DNA (mtDNA) present in all human cells has proven to be a veritable Pandora's box of pathogenic mutations and rearrangements. In this review, we summarize the distinctive rules of mitochondrial genetics (maternal inheritance, mitotic segregation, heteroplasmy and threshold effect), stress the relatively high prevalence
Guido Davidzon, Salvatore DiMauro
openaire   +3 more sources

Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder [PDF]

, 2015
Background: Mitochondrial disease is often suspected in cases of severe epileptic encephalopathy especially when a complex movement disorder, liver involvement and progressive developmental regression are present.
Collins, Abigail E, Coughlin, Curtis R, II, Creadon-Swindell, Geralyn, Friederich, Marisa W, Geiger, Elizabeth A, Minczuk, Michal, Powell, Christopher A, Scharer, Gunter H, Shaikh, Tamim H, Swanson, Michael A, Van Coster, Rudy, Van Hove, Johan LK, Vanlander, Arnaud, Yu, Hung-Chun   +13 more
core   +2 more sources

A rapid and efficient method for enriching mitochondrial DNA from plants

Mitochondrial DNA. Part B. Resources, 2018
Current mitochondrial purification techniques are tedious and protracted due to their emphasis on recovering physiologically active mitochondria. However, for studies that are exclusively interested in isolating mitochondrial DNA (mtDNA) for applications
Mackenzie M. Strehle, Emma Purfeerst, Alan C. Christensen   +2 more
doaj   +1 more source

Determination of Mitochondrial DNA Upon Drug Treatment

Bio-Protocol, 2015
Drug-induced mitochondrial injury can be caused by many different mechanisms including inhibition of mitochondrial DNA replication, transcription, translation, and altered protein function.
Michel Perron, Joy Feng
doaj   +1 more source