Results 71 to 80 of about 2,640,580 (326)

Discontinuous transcription of ribosomal DNA in human cells.

PLoS ONE, 2020
Numerous studies show that various genes in all kinds of organisms are transcribed discontinuously, i.e. in short bursts or pulses with periods of inactivity between them.
Evgeny Smirnov, Peter Trosan, Joao Victor Cabral, Pavel Studeny, Sami Kereïche, Katerina Jirsova, Dušan Cmarko   +6 more
doaj   +1 more source

PCR primers for metazoan nuclear 18S and 28S ribosomal DNA sequences. [PDF]

PLoS ONE, 2012
BACKGROUND: Metagenetic analyses, which amplify and sequence target marker DNA regions from environmental samples, are increasingly employed to assess the biodiversity of communities of small organisms. Using this approach, our understanding of microbial
Ryuji J Machida, Nancy Knowlton
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci

Biomedicines
While genotoxic chemotherapeutic agents are among the most effective tools to combat cancer, they are often associated with severe adverse effects caused by indiscriminate DNA damage in non-tumor tissue as well as increased risk of secondary ...
Donald P. Cameron, Jirawas Sornkom, Sameerh Alsahafi, Denis Drygin, Gretchen Poortinga, Grant A. McArthur, Nadine Hein, Ross Hannan, Konstantin I. Panov   +8 more
doaj   +1 more source

Morphological and molecular identification of filamentous fungi isolated from cosmetic powders

Brazilian Archives of Biology and Technology, 2012
Seven fungi were isolated from 50 samples of cosmetic powders. Morphological analyses and ribosomal DNA Internal Transcribed Spacers sequencing were performed which allowed the discrimination of the isolated fungi as Aspergillus fumigatus, Penicillium sp.
Flavia Cristina Jastale Pinto, Daniel Braga de Lima, Bruna Carla Agustini, Cibelle Borba Dallagassa, Maria Fernanda Shimabukuro, Márcio Chimelli, Debora Brand, Cyntia Maria Telles Fadel-Picheth, Tania Maria Bordin Bonfim   +8 more
doaj   +1 more source

The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. [PDF]

, 2017
Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7).
Garza, Renee M, Kennedy, Brian K, La Spada, Albert R, Mason, Amanda G, McCormick, Mark A, Patel, Bhumil, Pillus, Lorraine   +6 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Catalogue of fungi in China 2. Ramaria from northern China

Mycology
The species of Ramaria are coralloid-fungi with intricately branched and vividly coloured basidiomata. There are many studies on the genus Ramaria in China, but molecular phylogenetic analysis is rarely employed.
Ying Li, Ning Mao, Yu-Xing Zhang, Hao-Yu Fu, Li Fan   +4 more
doaj   +1 more source

An efficient method for DNA extraction from Cladosporioid fungi [PDF]

, 2010
We developed an efficient method for DNA extraction from Cladosporioid fungi, which are important fungal plant pathogens. The cell wall of Cladosporioid fungi is often melanized, which makes it difficult to extract DNA from their cells.
Abd-Elsalam, K.A., Bahkali, A.H., Moslem, M.A., Wit, P.J.G.M., de   +3 more
core   +2 more sources

Comparison of RNA-Seq by poly (A) capture, ribosomal RNA depletion, and DNA microarray for expression profiling

BMC Genomics, 2014
BackgroundRNA sequencing (RNA-Seq) is often used for transcriptome profiling as well as the identification of novel transcripts and alternative splicing events. Typically, RNA-Seq libraries are prepared from total RNA using poly(A) enrichment of the mRNA
Wei Zhao, Xiaping He, K. Hoadley, J. Parker, D. Hayes, C. Perou   +5 more
semanticscholar   +1 more source