GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Morphological and molecular description of Ditylenchus baoqingensis n. sp. (Rhabditida: Anguinidae) from Chinese cabbages (Brassica rapa) in China. [PDF]
Sci RepQiu WJ, Ni CH, Zhou H, Xie H, Xu CL.
europepmc +1 more source
The FEBS Journal, EarlyView.The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami +6 more
wiley +1 more source
<i>Trichoderma asperellum</i> and <i>T. asperelloides</i>: Comparative Genomic Study for Genes Implicated in Biocontrol and Biofertilizer Activities. [PDF]
J Fungi (Basel)Ismaiel A, Maul J, Millner P.
europepmc +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Culturable microbiota of reared mosquito fauna in Osogbo, Nigeria and their potential biological roles: a molecular insight. [PDF]
BMC Res NotesOyedara OO +9 more
europepmc +1 more source
Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance
The FEBS Journal, EarlyView.Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley +1 more source
Metagenomic identification of Acanthamoeba Rhysodes in chronic skin lesion: Case report and literature review. [PDF]
JAAD Case RepAcosta-España JD +4 more
europepmc +1 more source
Insect Molecular Biology, EarlyView.RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour +8 more
wiley +1 more source
Dermatomycosis Caused by Non-Dermatophyte Agents; Diagnosis Based on Molecular Identification. [PDF]
MicrobiologyopenRanjbar Golafshani FZ +6 more
europepmc +1 more source