Results 101 to 110 of about 2,056,925 (301)

Cellular Processing Pathways Contribute to the Activation of Etoposide- Induced DNA Damage Responses

, 2009
Cytotoxic action (tumor cell killing) and carcinogenic side effect ( therapy-related secondary leukemia) of etoposide are closely related to its ability in stabilizing topoisomerase II cleavable complex (TOP2cc), a unique form of protein- linked DNA ...
FAN, JIA-RONG;PENG, AN-LIN;LO, SHU-CHI;HUANG, TING-HSIANG;LI, TSAI-KUN, 范嘉榕;彭安林;羅淑祺;黃鼎翔;李財坤   +1 more
core   +1 more source

Decitabine-mediated DNA methylation dynamics at pericentromeric satellite 2 repeats

BMC Cancer
The hypomethylating agents (HMAs) 5-azacytidine (vidaza-AZA) and 5-aza-2′-deoxycytidine (decitabine-DAC) are part of the standard of care for the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). However, the molecular events
Enrica Sordini, Eugenia Ciurlia, Alessia Zanella, Benedetta Fogliardi, Dorela Lame, Antonella Poloni, Stefano Amatori, Mirco Fanelli   +7 more
doaj   +1 more source

Extrachromosomal circles of satellite repeats and 5S ribosomal DNA in human cells

Mobile DNA, 2010
Background Extrachomosomal circular DNA (eccDNA) is ubiquitous in eukaryotic organisms and was detected in every organism tested, including in humans. A two-dimensional gel electrophoresis facilitates the detection of eccDNA in preparations of genomic ...
Cohen Sarit, Agmon Neta, Sobol Olga, Segal Daniel   +3 more
doaj   +1 more source

Rapid Evolution of Horse Satellite DNA

Genomics, 1993
The major satellite of the horse genome consists of about 1 million copies of a 221-bp tandem repeat unit. By fluorescence in situ hybridization it has been localized in the centromeres of 58 of the 64 horse chromosomes. The donkey genome contains a similar but not identical satellite. Strikingly, the equine repeat did not hybridize to DNA of the Grevy
Wijers, E R, Zijlstra, C, Lenstra, J A
openaire   +3 more sources

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Antibiotics induce overexpression of alpha satellite DNA accompanied with epigenetic changes at alpha satellite arrays as well as genome-wide

Epigenetics & Chromatin
The transcription of satellite DNA is highly sensitive to environmental factors and represents a source of genomic instability. Therefore, tight regulation of (peri)centromeric transcription is essential for genome maintenance.
Sven Ljubić, Maja Matulić, Damir Đermić, Maria Chiara Feliciello, Alfredo Procino, Đurđica Ugarković, Isidoro Feliciello   +6 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Performance Assessment using ACM in DVB-S2/Advanced DVB-RCS Satellite Systems [PDF]

, 2009
This paper presents the benefits of using adaptive coding and modulation in DVB-S2/advanced DVB-RCS satellite systems. The results are based on a satellite system simulator which was developed during an ESA study.
Boussemart, Vincent, H. Brandt, Brandt, Hartmut, V. Boussemart   +3 more
core   +1 more source

Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression.

PLoS Biology
Noncoding satellite DNA repeats are abundant at the pericentromeric heterochromatin of eukaryotic chromosomes. During interphase, sequence-specific DNA-binding proteins cluster these repeats from multiple chromosomes into nuclear foci known as ...
Ankita Chavan, Lena Skrutl, Federico Uliana, Melanie Pfister, Franziska Brändle, Laszlo Tirian, Delora Baptista, Dominik Handler, David Burke, Anna Sintsova, Pedro Beltrao, Julius Brennecke, Madhav Jagannathan   +12 more
doaj   +1 more source