Results 211 to 220 of about 366,924 (267)

Development and Optimization of CRISPR/Cas9-Assisted Recombineering in <i>Escherichia albertii</i>. [PDF]

MicroPubl Biol
Khan SA, Miller TM, Bhatt S, Li E.
europepmc   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Double-stranded sperm DNA fragmentation measured with neutral comet assay as a predictor of IVF outcomes: evidence from three European clinics in a multi-centred prospective study. [PDF]

Hum Reprod
Humaidan P, Povlsen BB, Drakeley AJ, Jensen MB, Gabrielsen AV, McDowell SH, Moore L, Ledgerwood CJ, Rae L, Sloan A, Lawlor M, Poots L, Bailie E, Lunt RL, Newton E, Gregoire RC, Moore TCB, Esteves SC.   +17 more
europepmc   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Lymph node-targeted DNA engages TBK1/IFN-I-driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs. [PDF]

Sci Adv
Steinbuck MP, Seenappa LM, Zhan W, Palmer E, Jung MM, Jakubowski A, Cabana-Puig X, McNeil LK, Haqq CM, Fitzgerald KA, DeMuth PC.   +10 more
europepmc   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA. [PDF]

J Med Virol
Lee YM.
europepmc   +1 more source

SS-VIME: a single-source virome-microbiome extraction protocol toward comprehensive soil community analysis. [PDF]

Microbiol Spectr
Poursalavati A, Laforest-Lapointe I, Fall ML.   +2 more
europepmc   +1 more source

Direct evidence and quantification of homologous recognition between DNA duplexes. [PDF]

Proc Natl Acad Sci U S A
Stannard A, Haimov E, Hedley JG, Xiao Y, Di Antonio M, Oshanin G, Danilowicz C, Prentiss M, Di Michele L, Kornyshev AA.   +9 more
europepmc   +1 more source

Understanding single stranded DNA gaps: from formation to fate. [PDF]

Biochem J
Garg S, Moldovan GL.
europepmc   +1 more source