Results 1 to 10 of about 1,122,688 (209)
Epigenetic control of Epstein Barr Virus transcription – relevance to viral life cycle? [PDF]
Frontiers in Genetics, 2013 DNA-methylation normally leads to silencing of gene expression but Epstein-Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA-methylation is absolutely required for the expression of many viral genes.
Alison J. Sinclair
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DNA vaccines for viral diseases [PDF]
Brazilian Journal of Medical and Biological Research, 1999 DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants and excipients, or by delivery of DNA-coated gold particles to the epidermis through biolistic immunization.
J.J. Donnelly, J.B. Ulmer
doaj +7 more sources
Force steps during viral DNA packaging ? [PDF]
Journal of the Mechanics and Physics of Solids, 2003 Biophysicists and structural biologists increasingly acknowledge the role played by the mechanical properties of macromolecules as a critical element in many biological processes.
Alberts +29 more
core +4 more sources
Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
mBio, 2023 Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro +18 more
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PLoS Pathogens, 2023 Proliferating cell nuclear antigen (PCNA) forms a homotrimer that encircles replicating DNA and is bound by DNA polymerases to add processivity to cellular DNA synthesis. In addition, PCNA acts as a scaffold to recruit DNA repair and chromatin remodeling
Jessica E Packard +3 more
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Replication Compartments—The Great Survival Strategy for Epstein–Barr Virus Lytic Replication
Microorganisms, 2022 During Epstein–Barr virus (EBV) lytic replication, viral DNA synthesis is carried out in viral replication factories called replication compartments (RCs), which are located at discrete sites in the nucleus.
Atsuko Sugimoto
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HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors
Viruses, 2021 DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription.
Jessica E. Packard, Jill A. Dembowski
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npj Vaccines, 2021 Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic.
Peter Radvak +10 more
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Membrane-assisted viral DNA ejection [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017 Genome packaging and delivery are fundamental steps in the replication cycle of all viruses. Icosahedral viruses with linear double-stranded DNA (dsDNA) usually package their genome into a preformed, rigid procapsid using the power generated by a virus-encoded packaging ATPase.
Santos Pérez, Isaac +5 more
openaire +4 more sources
Inhibition of histone methyltransferase SETD8 represses DNA virus replication
Cell Insight, 2022 Multiple diseases, such as cancer and neural degeneration diseases, are related with the latent infection of DNA viruses. However, it is still difficult to clean up the latent DNA viruses and new anti-viral strategies are critical for disease treatment ...
Lin Chen +6 more
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