Results 1 to 10 of about 3,434,546 (345)

DNA vaccines for viral diseases [PDF]

Brazilian Journal of Medical and Biological Research, 1999
DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants and excipients, or by delivery of DNA-coated gold particles to the epidermis through biolistic immunization.
J.J. Donnelly, J.B. Ulmer
doaj   +7 more sources

Epigenetic control of Epstein Barr Virus transcription – relevance to viral life cycle? [PDF]

Frontiers in Genetics, 2013
DNA-methylation normally leads to silencing of gene expression but Epstein-Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA-methylation is absolutely required for the expression of many viral genes.
Alison J. Sinclair
doaj   +3 more sources

Biological Consequences of Tightly Bent DNA: The Other Life of a Macromolecular Celebrity [PDF]

arXiv, 2006
The mechanical properties of DNA play a critical role in many biological functions. For example, DNA packing in viruses involves confining the viral genome in a volume (the viral capsid) with dimensions that are comparable to the DNA persistence length.
Garcia, Hernan G., Grayson, Paul, Han, Lin, Inamdar, Mandar, Kondev, Jane, Nelson, Philip C., Phillips, Rob, Widom, Jonathan, Wiggins, Paul A.   +8 more
arxiv   +6 more sources

Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication. [PDF]

PLoS ONE, 2012
Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified.
Tamara Evans Braun, Emma Poole, John Sinclair   +2 more
doaj   +11 more sources

Dynamics of DNA Ejection From Bacteriophage [PDF]

, 2005
The ejection of DNA from a bacterial virus (``phage'') into its host cell is a biologically important example of the translocation of a macromolecular chain along its length through a membrane. The simplest mechanism for this motion is diffusion, but in the case of phage ejection a significant driving force derives from the high degree of stress to ...
Ambjornsson, Bohm, Evilevitch, Gabashvili, Gonzales-Huici, Graff, Grayson, Howard, Kemp, Kindt, Landau, Letellier, Letellier, Lubensky, Luby-Phelps, Mandar M. Inamdar, Metzler, Molineux, Muthukumar, Neidhardt, Nelson, Novick, Odijk, Odijk, Peskin, Purohit, Purohit, Rau, Riemer, Rob Phillips, Robison, Shea, Simon, Smith, Sung, Tao, Terrell, Tzlil, van Kampen, Wang, William M. Gelbart, Zandi, Zimmerman   +42 more
arxiv   +5 more sources

DNA waves and water [PDF]

, 2010
Some bacterial and viral DNA sequences have been found to induce low frequency electromagnetic waves in high aqueous dilutions. This phenomenon appears to be triggered by the ambient electromagnetic background of very low frequency. We discuss this phenomenon in the framework of quantum field theory.
A Tedeschi, C Lavallee, Del Giudice E, Del Giudice E, E Del Giudice, G Vitiello, J Aissa, L Montagnier, Landau LD, Montagnier L, Nickolaenko A P, Szent-Gyorgyi A, Voeikov VL   +12 more
arxiv   +4 more sources

NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing. [PDF]

PLoS Pathogens
Methylation of the DNA genome plays an important role in viral gene inactivation. However, the role of DNA methylation in human bocavirus (HBoV) remains unclear.
Shuangkang Qin, Honghe Chen, Chuchu Tian, Zhen Chen, Li Zuo, Xueyan Zhang, Haojie Hao, Fang Huang, Haibin Liu, Xiulian Sun, Wuxiang Guan   +10 more
doaj   +2 more sources

Forces During Bacteriophage DNA Packaging and Ejection [PDF]

, 2004
The conjunction of insights from structural biology, solution biochemistry, genetics and single molecule biophysics has provided a renewed impetus for the construction of quantitative models of biological processes. One area that has been a beneficiary of these experimental techniques is the study of viruses.
Arsuaga, Baker, Bednar, Black, Bohm, Booy, Castelnovo, Cerritelli, Cordova, de Vries, Dokland, Earnshaw, Echols, Endy, Evilevitch, Evilevitch, Feiss, Flint, Gabashvili, Gelbart, Hershey, Iwasaki, Jané Kondev, Kanamaru, Kindt, Klug, La Scola, LaMarque, Landau, Lata, Leiman, Letellier, Lyubartsev, Mandar M. Inamdar, Marenduzzo, Molineux, Nelson, Novick, Odijk, Odijk, Odijk, Odijk, Odijk, Parsegian, Paul D. Grayson, Prashant K. Purohit, Ptashne, Purohit, Purohit, Raspaud, Rau, Rau, Reddy, Richards, Riemer, Rob Phillips, Shibata, Simpson, Smith, Smith, Strey, Tama, Tao, Todd M. Squires, Tzlil, Young   +65 more
arxiv   +5 more sources

A Liquid Crystal Model of Viral DNA Encapsidation [PDF]

arXiv, 2017
A liquid crystal continuum modeling framework for icosahedra bacteriophage viruses is developed and tested. The main assumptions of the model are the chromonic columnar hexagonal structure of confined DNA, the high resistance to bending and the phase transition from solid to fluid-like states as the concentration of DNA in the capsid decreases during ...
Arsuaga, Javier, Calderer, Maria-Carme, Hiltner, Lindsey, Vazquez, Mariel   +3 more
arxiv   +2 more sources

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

mBio, 2023
Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. F. Sousa, M. Métifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Munier-Lehmann, C. Richetta, M. Maisch, J. Dutrieux, J. Batisse, M. Ruff, O. Delelis, P. Lesbats, V. Parissi   +18 more
doaj   +1 more source