Results 11 to 20 of about 2,726,530 (186)
mSystems, 2022 Human cells identify invading pathogens and activate immune signaling pathways through a wide array of pattern recognition receptors, including DNA sensors.
Timothy R. Howard +3 more
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Viral DNA Polymerase Inhibitors [PDF]
, 2009 © Springer Science+Business Media, LLC 2009. All rights reserved. DNA viruses, as well as their host cells, require a DNA-dependent DNA polymerase to faithfully replicate their genomes. Viruses with small DNA genomes, such as papillomaviruses and polyomaviruses, have a limited coding capacity and utilize mainly the host replication machinery for their ...
Andrei, Graciela +2 more
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Dangerous Liaisons: Long-Term Replication with an Extrachromosomal HPV Genome
Viruses, 2021 Papillomaviruses cause persistent, and usually self-limiting, infections in the mucosal and cutaneous surfaces of the host epithelium. However, in some cases, infection with an oncogenic HPV can lead to cancer.
Alix Warburton +2 more
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Cellular Sensing of Viral DNA and Viral Evasion Mechanisms [PDF]
Annual Review of Microbiology, 2014 Mammalian cells detect foreign DNA introduced as free DNA or as a result of microbial infection, leading to the induction of innate immune responses that block microbial replication and the activation of mechanisms that epigenetically silence the genes encoded by the foreign DNA.
Megan H, Orzalli, David M, Knipe
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SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products. [PDF]
PLoS Pathogens, 2014 Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage.
Gregory A Sowd +5 more
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Biodiversity and distribution of polar freshwater DNA viruses [PDF]
, 2015 Viruses constitute the most abundant biological entities and a large reservoir of genetic diversity on Earth. Despite the recent surge in their study, our knowledge on their actual biodiversity and distribution remains sparse.
López-Bueno, Alberto +4 more
core +1 more source
Parvovirus b19 DNA CpG dinucleotide methylation and epigenetic regulation of viral expression. [PDF]
PLoS ONE, 2012 CpG DNA methylation is one of the main epigenetic modifications playing a role in the control of gene expression. For DNA viruses whose genome has the ability to integrate in the host genome or to maintain as a latent episome, a correlation has been ...
Francesca Bonvicini +4 more
doaj +1 more source
Membrane-assisted viral DNA ejection [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017 Genome packaging and delivery are fundamental steps in the replication cycle of all viruses. Icosahedral viruses with linear double-stranded DNA (dsDNA) usually package their genome into a preformed, rigid procapsid using the power generated by a virus-encoded packaging ATPase.
Santos Pérez, Isaac +5 more
openaire +5 more sources
Non-viral approaches to gene therapy [PDF]
, 1993 Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Wagner, Ernst, Cotten, Matt
core +1 more source
Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization
Vaccine: X, 2019 Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current in vivo tumorigenicity assays can be time-consuming and results can be equivocal, especially for weakly tumorigenic cells ...
Haruhiko Murata +7 more
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