DNA vaccines for viral diseases [PDF]
Brazilian Journal of Medical and Biological Research, 1999 DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants and excipients, or by delivery of DNA-coated gold particles to the epidermis through biolistic immunization.
J.J. Donnelly, J.B. Ulmer
doaj +7 more sources
Epigenetic control of Epstein Barr Virus transcription – relevance to viral life cycle? [PDF]
Frontiers in Genetics, 2013 DNA-methylation normally leads to silencing of gene expression but Epstein-Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA-methylation is absolutely required for the expression of many viral genes.
Alison J. Sinclair
doaj +3 more sources
Force steps during viral DNA packaging ? [PDF]
Journal of the Mechanics and Physics of Solids, 2003 Biophysicists and structural biologists increasingly acknowledge the role played by the mechanical properties of macromolecules as a critical element in many biological processes.
Alberts +29 more
core +6 more sources
Cellular Sensing of Viral DNA and Viral Evasion Mechanisms [PDF]
Annual Review of Microbiology, 2014 Mammalian cells detect foreign DNA introduced as free DNA or as a result of microbial infection, leading to the induction of innate immune responses that block microbial replication and the activation of mechanisms that epigenetically silence the genes encoded by the foreign DNA.
David M. Knipe, Megan H. Orzalli
openaire +4 more sources
Global diversity and biogeography of DNA viral communities in activated sludge systems. [PDF]
Microbiome, 2023 Background Activated sludge (AS) systems in wastewater treatment plants (WWTPs) harbor enormous viruses that regulate microbial metabolism and nutrient cycling, significantly influencing the stability of AS systems.
Fan X +10 more
europepmc +2 more sources
CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections. [PDF]
Viruses, 2022 Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration and contribute to their activation. Chemokines are crucial inflammatory mediators that play a key role in managing viral infections, during which the profile of ...
Elemam NM, Talaat IM, Maghazachi AA.
europepmc +2 more sources
Efficient Transient Expression of Recombinant Proteins Using DNA Viral Vectors in Freshwater Microalgal Species. [PDF]
Front Plant Sci, 2021 The increase in the world population, the advent of new infections and health issues, and the scarcity of natural biological products have spotlighted the importance of recombinant protein technology and its large-scale production in a cost-effective ...
Malla A +3 more
europepmc +2 more sources
Marine DNA Viral Macro- and Microdiversity from Pole to Pole. [PDF]
Cell, 2019 Gregory AC +33 more
europepmc +2 more sources
Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
mBio, 2023 Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro +18 more
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Replication Compartments—The Great Survival Strategy for Epstein–Barr Virus Lytic Replication
Microorganisms, 2022 During Epstein–Barr virus (EBV) lytic replication, viral DNA synthesis is carried out in viral replication factories called replication compartments (RCs), which are located at discrete sites in the nucleus.
Atsuko Sugimoto
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