Viral DNA Polymerase Inhibitors [PDF]
, 2009 © Springer Science+Business Media, LLC 2009. All rights reserved. DNA viruses, as well as their host cells, require a DNA-dependent DNA polymerase to faithfully replicate their genomes. Viruses with small DNA genomes, such as papillomaviruses and polyomaviruses, have a limited coding capacity and utilize mainly the host replication machinery for their ...
Andrei, Graciela +2 more
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SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products. [PDF]
PLoS Pathogens, 2014 Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage.
Gregory A Sowd +5 more
doaj +1 more source
Dangerous Liaisons: Long-Term Replication with an Extrachromosomal HPV Genome
Viruses, 2021 Papillomaviruses cause persistent, and usually self-limiting, infections in the mucosal and cutaneous surfaces of the host epithelium. However, in some cases, infection with an oncogenic HPV can lead to cancer.
Alix Warburton +2 more
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Parvovirus b19 DNA CpG dinucleotide methylation and epigenetic regulation of viral expression. [PDF]
PLoS ONE, 2012 CpG DNA methylation is one of the main epigenetic modifications playing a role in the control of gene expression. For DNA viruses whose genome has the ability to integrate in the host genome or to maintain as a latent episome, a correlation has been ...
Francesca Bonvicini +4 more
doaj +1 more source
Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization
Vaccine: X, 2019 Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current in vivo tumorigenicity assays can be time-consuming and results can be equivocal, especially for weakly tumorigenic cells ...
Haruhiko Murata +7 more
doaj +1 more source
Sequence organization of feline leukemis virus DNA in infected cells [PDF]
, 1980 A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV.
Casey, James W. +3 more
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Early and Highly Suppressive ART are Main Factors Associated with Low Viral Reservoir in European Perinatally HIV Infected Children [PDF]
, 2018 BACKGROUND: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. SETTING: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected ...
Babiker, Abdel +22 more
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Cellular Sensing of Viral DNA and Viral Evasion Mechanisms [PDF]
Annual Review of Microbiology, 2014 Mammalian cells detect foreign DNA introduced as free DNA or as a result of microbial infection, leading to the induction of innate immune responses that block microbial replication and the activation of mechanisms that epigenetically silence the genes encoded by the foreign DNA.
Megan H, Orzalli, David M, Knipe
openaire +2 more sources
The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]
, 1985 The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael +9 more
core +1 more source
Asian Pacific Journal of Cancer Prevention, 2012 OBJECTIVES To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA).
S. Siriaunkgul +6 more
semanticscholar +1 more source