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Viral DNA Polymerase Inhibitors [PDF]
, 2009 © Springer Science+Business Media, LLC 2009. All rights reserved. DNA viruses, as well as their host cells, require a DNA-dependent DNA polymerase to faithfully replicate their genomes. Viruses with small DNA genomes, such as papillomaviruses and polyomaviruses, have a limited coding capacity and utilize mainly the host replication machinery for their ...
Andrei, Graciela +2 more
openaire +2 more sources
Parvovirus b19 DNA CpG dinucleotide methylation and epigenetic regulation of viral expression. [PDF]
PLoS ONE, 2012 CpG DNA methylation is one of the main epigenetic modifications playing a role in the control of gene expression. For DNA viruses whose genome has the ability to integrate in the host genome or to maintain as a latent episome, a correlation has been ...
Francesca Bonvicini +4 more
doaj +1 more source
Designer DNA nanostructures for viral inhibition [PDF]
Nature Protocols, 2022 Emerging viral diseases can substantially threaten national and global public health. Central to our ability to successfully tackle these diseases is the need to quickly detect the causative virus and neutralize it efficiently. Here we present the rational design of DNA nanostructures to inhibit dengue virus infection.
Shaokang Ren +8 more
openaire +2 more sources
Sequence organization of feline leukemis virus DNA in infected cells [PDF]
, 1980 A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV.
Casey, James W. +3 more
core +1 more source
Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization
Vaccine: X, 2019 Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current in vivo tumorigenicity assays can be time-consuming and results can be equivocal, especially for weakly tumorigenic cells ...
Haruhiko Murata +7 more
doaj +1 more source
Force steps during viral DNA packaging ? [PDF]
, 2003 Biophysicists and structural biologists increasingly acknowledge the role played by the mechanical properties of macromolecules as a critical element in many biological processes.
Alberts +29 more
core +2 more sources
Early and Highly Suppressive ART are Main Factors Associated with Low Viral Reservoir in European Perinatally HIV Infected Children [PDF]
, 2018 BACKGROUND: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. SETTING: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected ...
Babiker, Abdel +22 more
core +2 more sources
HSV-1 not only in human vestibular ganglia but also in the vestibular labyrinth [PDF]
, 2001 Reactivation of herpes simplex virus type 1 (HSV-1) in the vestibular ganglion (VG) is the suspected cause of vestibular neuritis (VN). Recent studies reported the presence of HSV-1 DNA not only in human VGs but also in vestibular nuclei, a finding that ...
Arbusow, Viktor +4 more
core +1 more source
Asian Pacific Journal of Cancer Prevention, 2012 OBJECTIVES To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA).
S. Siriaunkgul +6 more
semanticscholar +1 more source
Broad Surveys of DNA Viral Diversity Obtained through Viral Metagenomics of Mosquitoes
PLoS ONE, 2011 Viruses are the most abundant and diverse genetic entities on Earth; however, broad surveys of viral diversity are hindered by the lack of a universal assay for viruses and the inability to sample a sufficient number of individual hosts.
T. Ng +9 more
semanticscholar +1 more source