Results 21 to 30 of about 548,105 (272)

Capstan friction model for DNA ejection from bacteriophages [PDF]

Physical Review Letters vol.109, 248105 (2012), 2013
Bacteriophages infect cells by attaching to the outer membrane and injecting their DNA into the cell.The phage DNA is then transcribed by the cell's transcription machinery.A number of physical mechanisms by which DNA can be translocated from the phage capsid into the cell have been identified.
arxiv   +1 more source

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins [PDF]

Journal of Visualized Experiments, 2017
The goal of this protocol is to isolate herpes simplex virus type 1 (HSV-1) DNA from infected cells for the identification of associated viral and cellular proteins by mass spectrometry. Although proteins that interact with viral genomes play major roles in determining the outcome of infection, a comprehensive analysis of viral genome associated ...
Jill A. Dembowski, Neal A. DeLuca
openaire   +3 more sources

Phenotypic continuum of NFU1‐related disorders

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022
Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov, Maha S. Zaki, Tracy Lau, Sambuddha Sen, Reza Azizimalamiri, Mina Zamani, Gözde Yeşil Sayin, Taru Hilander, Stephanie Efthymiou, Viorica Chelban, Ruth Brown, Kyle Thompson, Maria Irene Scarano, Jaya Ganesh, Kairgali Koneev, Ismail Musab Gülaçar, Richard Person, Dinara Sadykova, Yerdan Maidyrov, Tahereh Seifi, Aizhan Zadagali, Geneviève Bernard, Katrina Allis, Houda Zghal Elloumi, Amanda Lindy, Ehsan Taghiabadi, Sumit Verma, Rachel Logan, Brian Kirmse, Renkui Bai, Shaimaa M. Khalaf, Mohamed S. Abdel‐Hamid, Alireza Sedaghat, Gholamreza Shariati, Mahmoud Issa, Jawaher Zeighami, Hasnaa M. Elbendary, Garry Brown, Robert W. Taylor, Hamid Galehdari, Joseph J. Gleeson, Christopher J. Carroll, James A. Cowan, Andres Moreno‐De‐Luca, Henry Houlden, Reza Maroofian   +45 more
wiley   +1 more source

Host Cell Nucleolin Is Required To Maintain the Architecture of Human Cytomegalovirus Replication Compartments

mBio, 2012
Drastic reorganization of the nucleus is a hallmark of herpesvirus replication. This reorganization includes the formation of viral replication compartments, the subnuclear structures in which the viral DNA genome is replicated.
Blair L. Strang, Steeve Boulant, Tomas Kirchhausen, Donald M. Coen   +3 more
doaj   +1 more source

Preparation of Viral DNA from Nucleocapsids [PDF]

Journal of Visualized Experiments, 2011
Viruses are obligate cellular parasites, and thus the study of their DNA requires isolating viral material away from host cell contaminants and DNA. Several downstream applications require large quantities of pure viral DNA, which is provided by this protocol.
Lynn W. Enquist, Yolanda R. Tafuri, Moriah L. Szpara   +2 more
openaire   +3 more sources

XVir: A Transformer-Based Architecture for Identifying Viral Reads from Cancer Samples [PDF]

arXiv, 2023
It is estimated that approximately 15% of cancers worldwide can be linked to viral infections. The viruses that can cause or increase the risk of cancer include human papillomavirus, hepatitis B and C viruses, Epstein-Barr virus, and human immunodeficiency virus, to name a few.
arxiv  

Chinese Giant Salamander Iridovirus 025L Is a Viral Essential Gene

Viruses, 2023
Ranavirus is a large nucleocytoplasmic DNA virus. Chinese giant salamander iridovirus (CGSIV) belongs to the ranavirus genus, and its replication involves a series of essential viral genes.
Zijing Liu, Daofa Xie, Shirong Nong, Yingzi Wu, Suxian Huang, Xianhui He, Tianhong Zhou, Wei Li   +7 more
doaj   +1 more source

Designer DNA nanostructures for viral inhibition [PDF]

Nature Protocols, 2022
Emerging viral diseases can substantially threaten national and global public health. Central to our ability to successfully tackle these diseases is the need to quickly detect the causative virus and neutralize it efficiently. Here we present the rational design of DNA nanostructures to inhibit dengue virus infection.
Shaokang Ren, Keith Fraser, Lili Kuo, Neha Chauhan, Addison T. Adrian, Fuming Zhang, Robert J. Linhardt, Paul S. Kwon, Xing Wang   +8 more
openaire   +2 more sources

Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation

mBio, 2020
The covalently closed circular (CCC) DNA of hepatitis B virus (HBV) functions as the only viral transcriptional template capable of producing all viral RNA species and is essential to initiate and sustain viral replication.
Jun Luo, Laurie Luckenbaugh, Hui Hu, Zhipeng Yan, Lu Gao, Jianming Hu   +5 more
doaj   +1 more source

Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA. [PDF]

PLoS Pathogens, 2013
Replication foci are generated by many viruses to concentrate and localize viral DNA synthesis to specific regions of the cell. Expression of the HPV16 E1 and E2 replication proteins in keratinocytes results in nuclear foci that recruit proteins ...
Nozomi Sakakibara, Dan Chen, Moon Kyoo Jang, Dong Wook Kang, Hans F Luecke, Shwu-Yuan Wu, Cheng-Ming Chiang, Alison A McBride   +7 more
doaj   +1 more source