Results 51 to 60 of about 874,984 (309)
, 2010 Chromosome organization plays a key role in many biological processes. In viruses genome organization is essential for the packaging and releasing of the genome as well as for maintaining the stability of the viral capsid. This organization varies across different families and is highly dependent on the virus morphogenetic pathway (Casjens, 1997).
Arsuaga, Javier +2 more
openaire +2 more sources
High sensitivity electrochemical DNA sensors for detection of somatic mutations in FFPE samples [PDF]
arXiv, 2022 We offer new high-performance label-free electrochemical impedimetric DNA sensors of non-faradaic type. The DNA sensors based on a platform of crystalline carbon nanotube (CNT) arrays are fabricated by the Langmuir--Blodgett (LB) deposition technique. The CNT arrays are suspended on a nanoporous anodic alumina (aluminium oxide, AOA) support.
arxiv
A novel cassette method for probe evaluation in the designed biochips [PDF]
, 2014 A critical step in biochip design is the selection of probes with identical hybridisation characteristics. In this article we describe a novel method for evaluating DNA hybridisation probes, allowing the fine-tuning of biochips, that uses cassettes with ...
Al-humam, Abdulmohsen A. +7 more
core +2 more sources
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress
eLife, 2018 The mechanisms by which mammalian cells recognize and epigenetically restrict viral DNA are not well defined. We used herpes simplex virus with bioorthogonally labeled genomes to detect host factors recruited to viral DNA shortly after its nuclear entry ...
Joseph M Cabral +2 more
doaj +1 more source
Nature Communications, 2022 cGAS senses viral DNA and forms cytosolic cGAS-DNA granules to mediate anti-DNA viral signaling pathway. Here the authors show that PCBP2 interacts with cGAS and antagonizes condensation of cGAS-DNA granules, thus maintaining host immune homeostasis.
Haiyan Gu +11 more
doaj +1 more source
Loops are Geometric Catalysts for DNA Integration [PDF]
arXiv, 2023 The insertion of HIV and other DNA elements within genomes underpins both genetic diversity and disease when unregulated. Most of these insertions are not random and occupy specific positions within the genome but the physical mechanisms underlying the integration site selection are poorly understood.
arxiv
Specific antigen of tumor cell transformed by DNA extracted from SV-40 virus [PDF]
, 1967 In the immunofluorescent study it has been revealed that rabbit sera immunized with transformed cells induced by SV-40 DNA, produce circulating antibody capable of re:lcting with intranuclear antigens synthesized by SV-40 complyte virus transforming ...
Grace, James T. +5 more
core +1 more source
Human colon organoid differentiation from induced pluripotent stem cells using an improved method
FEBS Letters, EarlyView.We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee +4 more
wiley +1 more source
DNA Scrunching in the Packaging of Viral Genomes [PDF]
The Journal of Physical Chemistry B, 2016 The motors that drive double-stranded DNA (dsDNA) genomes into viral capsids are among the strongest of all biological motors for which forces have been measured, but it is not known how they generate force. We previously proposed that the DNA is not a passive substrate but that it plays an active role in force generation. This "scrunchworm hypothesis"
Harold D. Kim +4 more
openaire +3 more sources
FEBS Letters, EarlyView.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source