Results 51 to 60 of about 3,781,819 (347)
Possible DNA Viral Factors of Human Breast Cancer
Cancers, 2010 Viruses are considered to be one of the high-risk factors closely related to human breast cancer. However, different studies of viruses in breast cancer present conflicting results and some of these works remain in dispute.
Chun-Ru Hsu +3 more
semanticscholar +1 more source
Replication of Epstein-Barr Viral DNA [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Epstein-Barr virus (EBV) is a paradigm for human tumor viruses: it is the first virus recognized to cause cancer in people; it causes both lymphomas and carcinomas; yet these tumors arise infrequently given that most people in the world are infected with the virus. EBV is maintained extrachromosomally in infected normal and tumor cells.
Wolfgang, Hammerschmidt, Bill, Sugden
openaire +2 more sources
Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion [PDF]
, 2005 Type IB DNA topoisomerases cleave and rejoin one strand of the DNA duplex, allowing for the removal of supercoils generated during replication and transcription.
Dekker, Cees +5 more
core +2 more sources
, 2010 Chromosome organization plays a key role in many biological processes. In viruses genome organization is essential for the packaging and releasing of the genome as well as for maintaining the stability of the viral capsid. This organization varies across different families and is highly dependent on the virus morphogenetic pathway (Casjens, 1997).
Arsuaga, Javier +2 more
openaire +2 more sources
DNA Scrunching in the Packaging of Viral Genomes [PDF]
The Journal of Physical Chemistry B, 2016 The motors that drive double-stranded DNA (dsDNA) genomes into viral capsids are among the strongest of all biological motors for which forces have been measured, but it is not known how they generate force. We previously proposed that the DNA is not a passive substrate but that it plays an active role in force generation. This "scrunchworm hypothesis"
James T, Waters +4 more
openaire +2 more sources
EFFICIENT PROPAGATION OF ARCHETYPE JC POLYOMAVIRUS IN COS-7 CELLS: EVALUATION OF REARRANGEMENTS WITHIN NCCR STRUCTURAL ORGANIZATION DURING TRANSFECTION. [PDF]
, 2017 John Cunningham virus (JCPyV) is an ubiqui-tous human pathogen that causes disease in immunocom-promised patients. The JCPyV genome is composed of an early region and a late region, which are physically sepa-rated by the ...
Anzivino, Elena +7 more
core +1 more source
Advances in Non-Viral DNA Vectors for Gene Therapy
Genes, 2017 Uses of viral vectors have thus far eclipsed uses of non-viral vectors for gene therapy delivery in the clinic. Viral vectors, however, have certain issues involving genome integration, the inability to be delivered repeatedly, and possible host ...
Cinnamon L. Hardee +3 more
semanticscholar +1 more source
Complexities associated with expression of Epstein-Barr virus (EBV) lytic origins of DNA replication. [PDF]
, 2007 EBV has two lytic origins (oriLyt) of DNA replication lying at divergent sites on the viral genome within a duplicated sequence (DS). The latter contains potential hairpin loops, ‘hinge’ elements and the promoters for transcripts from viral genes BHLF1 ...
Griffin, BE, Xue, SA
core +2 more sources
Advances in Cancer Biology - MetastasisWe have investigated the expression of selected genes and miRNAs that have been found to be associated with human cancer-stem cells for their involvement in the neoplastic evolution of our AGMK1-9T7 cell line from a non-tumorigenic status at passage (p ...
Andrew M. Lewis, Jr. +7 more
doaj +1 more source
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress
eLife, 2018 The mechanisms by which mammalian cells recognize and epigenetically restrict viral DNA are not well defined. We used herpes simplex virus with bioorthogonally labeled genomes to detect host factors recruited to viral DNA shortly after its nuclear entry ...
Joseph M Cabral +2 more
doaj +1 more source