Results 131 to 140 of about 2,258,474 (352)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Phosphorylation of Thyroid Hormone Receptors by Protein Kinase A Regulates DNA Recognition by Specific Inhibition of Receptor Monomer Binding [PDF]

, 1998
Christina Tzagarakis-Foster, Martin L. Privalsky   +1 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

the-alpha-fetoprotein-receptor-binding-fragment-localization-of-third-domain-interaction-sites-of-dna-repair-proteins/# [PDF]

, 2017
Gerald J. Mizejewski, G Mizejewski, G Mizejewski, G Mizejewski, G Mizejewski, S Naidu, M Peterson, B Spear, F Herve, K Rajkowski, M Martin, P Dessen, M Li, P Li, S He, G Du, G Li, G Mizejewski, G Mizejewski, A Atemezem, E Mbemba, R Marfaing, J Vaysse, M Pontet, G Mizejewski, M Li, H Li, C Li, S Zhou, G Mizejewski, G Posypanova, N Gorokhovets, V Makarov, L Savvateeva, G Posypanova, V Makarov, M Savvateeva, A Bereznikova, N Yabbarov, G Posypanova, E Vorontsov, S Obydenny, O Sharapova, N Pozdnykova, D Laurinavichyute, M Yurkova, O Sharapova, M Iurkova, S Andronova, A Fedorov, O Sharapova, N Pozdniakova, D Laurinavichiute, M Iurkova, D Carter, X He, S Munson, P Twigg, K Gernert, R Osmond, S Das, M Crouch, J Gerald, Mizejewski, G Mizejewski, J Duncan, J Reeves, T Cooke, B Friedenson, K Yoshida, Y Miki, N Lakhi, G Mizejewski, L Starita, J Parvin, Y Wang, D Cortez, P Yazdi, N Neff, J Paterson, B Henderson, B Xia, Q Sheng, K Nakanishi, A Ohashi, J Wu, R Buisson, A Dion-Cote, Y Coulombe, H Launay, N Kondo, A Takahashi, E Mori, T Noda, M O'driscoll, V Ruiz-Perez, C Woods, P Jeggo, A Smogorzewska, S Matsuoka   +99 more
openalex   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Influence of pH Variation on CooA Activity [PDF]

, 2016
CooA, a CO-sensing heme protein, acts as a transcriptional activator of CO-metabolizing proteins in bacteria such as Rhodospirillum rubrum and Carboxydothermus hydrogenoformans through sequence-specific DNA binding.
Clark, Robert W., DeVries, Rachael, Gunter, Amy, Weaver, Brian R   +3 more
core   +1 more source

Studying Ligand Binding and Site-Specific Mode of DNA Binding by Gamma-Butyrolactone Receptor Protein CprB from Streptomyces Coelicolor A3(2) using Two Different Fluorescence Techniques [PDF]

, 2015
Anwesha Biswas, G. Naresh Patwari, G. Krishnamoorthy, Ruchi Anand   +3 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Phase behaviour of DNA in presence of DNA-binding proteins

, 1994
To characterize the thermodynamical equilibrium of DNA chains interacting with a solution of non-specific binding proteins, a Flory-Huggins free energy model was implemented.
A Ervik, H Sveier, JE Juell, OB Samuelsen   +3 more
core   +1 more source