An acidic region of the 89K murine cytomegalovirus immediate early protein interacts with DNA [PDF]
, 1992 The product of the ie 1 gene, the regulatory immediate early protein pp89 of murine cytomegalovirus (MCMV), interacts with core histones, which can mediate the association of pp89 with DNA.
Koszinowski, Ulrich H. +3 more
core +1 more source
A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA
eLife, 2022 Clamp loaders place circular sliding clamp proteins onto DNA so that clamp-binding partner proteins can synthesize, scan, and repair the genome. DNA with nicks or small single-stranded gaps are common clamp-loading targets in DNA repair, yet these ...
Xingchen Liu +3 more
doaj +1 more source
Stochastic Ratchet Mechanisms for Replacement of Proteins Bound to DNA [PDF]
, 2013 Experiments indicate that unbinding rates of proteins from DNA can depend on the concentration of proteins in nearby solution. Here we present a theory of multi-step replacement of DNA-bound proteins by solution-phase proteins. For four different kinetic
Cocco, Simona +2 more
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Divergence of the mRNA targets for the Ssb proteins of bacteriophages T4 and RB69
Virology Journal, 2004 The single-strand binding (Ssb) protein of phage T4 (T4 gp32, product of gene 32) is a mRNA-specific autogenous translational repressor, in addition to being a sequence-independent ssDNA-binding protein that participates in phage DNA replication, repair ...
Petrov Vasiliy M +2 more
doaj +1 more source
Single-stranded DNA binding proteins influence APOBEC3A substrate preference
Scientific Reports, 2021 The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA ...
Amber L. Brown +5 more
doaj +1 more source
DNA binding proteins: outline of functional classification
Biomolecular Concepts, 2011 DNA-binding proteins composed of DNA-binding domains directly affect genomic functions, mainly by performing transcription, DNA replication or DNA repair.
Zheng Zhiming, Wang Ya
doaj +1 more source
Identification of DNA-binding proteins using support vector machines and evolutionary profiles
BMC Bioinformatics, 2007 Background Identification of DNA-binding proteins is one of the major challenges in the field of genome annotation, as these proteins play a crucial role in gene-regulation.
Gromiha Michael M +2 more
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Site-specific DNA Mapping of Protein Binding Orientation Using Azidophenacyl Bromide (APB)
Bio-Protocol, 2020 The orientation of a DNA-binding protein bound on DNA is determinative in directing the assembly of other associated proteins in the complex for enzymatic action.
Himasha Perera, Michael Trakselis
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and multiple sclerosis were once thought to be completely distinct entities that did not share any remarkable features, but new research is beginning to reveal more ...
Isabel Acosta-Galeana +4 more
doaj +1 more source
Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]
, 1988 The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the ...
Alberts +32 more
core +1 more source