Results 111 to 120 of about 1,668,835 (315)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins

EMBO Reports
In eukaryotes, DNA is packaged into chromatin with the help of highly conserved histone proteins. Together with DNA-binding proteins, posttranslational modifications (PTMs) on these histones play crucial roles in regulating genome function, cell fate ...
Anne-Sophie Pepin, Robert Schneider
doaj   +1 more source

DNA-binding proteins regulating pIP501 transfer and replication

Frontiers in Molecular Biosciences, 2016
pIP501 is a Gram-positive broad-host-range model plasmid intensively used for studying plasmid replication and conjugative transfer. It is a multiple antibiotic resistance plasmid frequently found in clinical Enterococcus faecalis and Enterococcus ...
Elisabeth Grohmann, Elisabeth Grohmann, Nikolaus Goessweiner-Mohr, Nikolaus Goessweiner-Mohr, Nikolaus Goessweiner-Mohr, Nikolaus Goessweiner-Mohr, Sabine Brantl   +6 more
doaj   +1 more source

High-Mobility-Group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus Type 1 proviral promoter [PDF]

, 2000
HMG I/Y appears to be a multifunctional protein that relies on in its ability to interact with DNA in a structure-specific manner and with DNA, binding transcriptional activators via distinct protein-protein interaction surfaces.
Henderson, A., Tremethick, D.J., Siddon, N., Reeves, R., Bunce, M.   +4 more
core   +1 more source

Noncanonical DNA-binding proteins: from identification to next generation peptide-based anticancer therapeutics [PDF]

, 2020
Background: G-quadruplexes and i-motifs are biologically relevant noncanonical DNA secondary structures, whose existence in vivo has been unambiguously demonstrated by their visualization in human cells.
bruno pagano
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Protein-protein interactions facilitate DNA binding by the glucocorticoid receptor DNA-binding domain.

Journal of Biological Chemistry, 1990
We have studied the interaction of the DNA-binding domain of the glucocorticoid receptor with a glucocorticoid response element from the tyrosine aminotransferase gene. This response element consists of two binding sites (half-sites) for the glucocorticoid receptor DNA-binding domain. The sequences of these two half-sites are not identical, and we have
K, Dahlman-Wright, H, Siltala-Roos, J, Carlstedt-Duke, J A, Gustafsson   +3 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication

Viruses, 2014
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
doaj   +1 more source

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Reid, J. E. (John E.), Kenneth J Evans, Dyer, Nigel, Dyer Nigel, Ott, Sascha, Reid John E   +17 more
core   +1 more source