Results 21 to 30 of about 1,985,752 (333)
Predicting target DNA sequences of DNA-binding proteins based on unbound structures. [PDF]
PLoS ONE, 2012 DNA-binding proteins such as transcription factors use DNA-binding domains (DBDs) to bind to specific sequences in the genome to initiate many important biological functions.
Chien-Yu Chen +5 more
doaj +1 more source
BMC Bioinformatics, 2017 Background DNA-binding proteins perform important functions in a great number of biological activities. DNA-binding proteins can interact with ssDNA (single-stranded DNA) or dsDNA (double-stranded DNA), and DNA-binding proteins can be categorized as ...
Wei Wang +6 more
doaj +1 more source
A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA
eLife, 2022 Clamp loaders place circular sliding clamp proteins onto DNA so that clamp-binding partner proteins can synthesize, scan, and repair the genome. DNA with nicks or small single-stranded gaps are common clamp-loading targets in DNA repair, yet these ...
Xingchen Liu +3 more
doaj +1 more source
An acidic region of the 89K murine cytomegalovirus immediate early protein interacts with DNA [PDF]
, 1992 The product of the ie 1 gene, the regulatory immediate early protein pp89 of murine cytomegalovirus (MCMV), interacts with core histones, which can mediate the association of pp89 with DNA.
Koszinowski, Ulrich H. +3 more
core +1 more source
eLife, 2021 Telomeres are nucleoprotein complexes at the ends of chromosomes and are indispensable for the protection and lengthening of terminal DNA. Despite the evolutionarily conserved roles of telomeres, the telomeric double-strand DNA (dsDNA)-binding proteins ...
Io Yamamoto +4 more
doaj +1 more source
Divergence of the mRNA targets for the Ssb proteins of bacteriophages T4 and RB69
Virology Journal, 2004 The single-strand binding (Ssb) protein of phage T4 (T4 gp32, product of gene 32) is a mRNA-specific autogenous translational repressor, in addition to being a sequence-independent ssDNA-binding protein that participates in phage DNA replication, repair ...
Petrov Vasiliy M +2 more
doaj +1 more source
Single-stranded DNA binding proteins influence APOBEC3A substrate preference
Scientific Reports, 2021 The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA ...
Amber L. Brown +5 more
doaj +1 more source
DNA binding proteins: outline of functional classification
Biomolecular Concepts, 2011 DNA-binding proteins composed of DNA-binding domains directly affect genomic functions, mainly by performing transcription, DNA replication or DNA repair.
Zheng Zhiming, Wang Ya
doaj +1 more source
Identification of DNA-binding proteins using support vector machines and evolutionary profiles
BMC Bioinformatics, 2007 Background Identification of DNA-binding proteins is one of the major challenges in the field of genome annotation, as these proteins play a crucial role in gene-regulation.
Gromiha Michael M +2 more
doaj +1 more source
Site-specific DNA Mapping of Protein Binding Orientation Using Azidophenacyl Bromide (APB)
Bio-Protocol, 2020 The orientation of a DNA-binding protein bound on DNA is determinative in directing the assembly of other associated proteins in the complex for enzymatic action.
Himasha Perera, Michael Trakselis
doaj +1 more source