Results 31 to 40 of about 1,985,752 (333)

Drosophila DNA-Binding Proteins in Polycomb Repression

Epigenomes, 2018
The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms.
Maksim Erokhin, Pavel Georgiev, Darya Chetverina   +2 more
doaj   +1 more source

Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. [PDF]

PLoS Biology, 2009
Polycomb group (PcG) and trithorax group (trxG) proteins are conserved chromatin factors that regulate key developmental genes throughout development.
Bernd Schuettengruber, Mythily Ganapathi, Benjamin Leblanc, Manuela Portoso, Rami Jaschek, Bas Tolhuis, Maarten van Lohuizen, Amos Tanay, Giacomo Cavalli   +8 more
doaj   +1 more source

RNA-binding proteins as a common ground for neurodegeneration and inflammation in amyotrophic lateral sclerosis and multiple sclerosis

Frontiers in Molecular Neuroscience, 2023
The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and multiple sclerosis were once thought to be completely distinct entities that did not share any remarkable features, but new research is beginning to reveal more ...
Isabel Acosta-Galeana, Ricardo Hernández-Martínez, Tania Reyes-Cruz, Erwin Chiquete, Jose de Jesus Aceves-Buendia   +4 more
doaj   +1 more source

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Aasland, Adams, Alen, Awad, Bailey, Baker, Baudin, Bird, Biswas, Biswas, Blank, Blosser, Boyer, Cairns, Chen, Cheng, Clapier, Clapier, Corona, Dang, Daniel P Ryan, Daubresse, David Martin, de Vries, Delmas, Eberharter, Eddy, Emsley, Fazzio, Ferreira, Flanagan, Flaus, Gangaraju, Gaspar-Maia, Grune, Hamiche, Hauk, Holm, Konev, Kouzarides, Lin, Lusser, McDaniel, Morettini, Okuda, Painter, Park, Pinskaya, Racki, Ramasubramanian Sundaramoorthy, Robinson, Sikorski, Simic, Sims, Stockdale, Stokes, Thastrom, Thompson, Tom Owen-Hughes, Tran, Tsukiyama, Vijender Singh, Walfridsson, Waterhouse, Yang, Zentner   +65 more
core   +4 more sources

Analyzing the Surface Structure of the Binding Domain on DNA and RNA Binding Proteins

IEEE Access, 2019
The study of nucleic acid-binding protein (NBP) has important significance for us to understand critical intracellular activities, such as the transmission of cellular genetic information, cell metabolism, substance transport, and signal transduction ...
Wei Wang, Keliang Li, Hehe Lv, Hongjun Zhang, Shiguang Zhang, Yun Zhou, Junwei Huang   +6 more
doaj   +1 more source

Grafting Miniature DNA Binding Proteins [PDF]

Chemistry & Biology, 2004
Miniature proteins serve as leads for biological and medicinal applications by positioning all amino acids necessary for biomolecular recognition on a compact protein structure. Protein grafting was recently used to create miniature helical proteins with high DNA binding affinity and specificity.
openaire   +2 more sources

Stochastic Ratchet Mechanisms for Replacement of Proteins Bound to DNA [PDF]

, 2013
Experiments indicate that unbinding rates of proteins from DNA can depend on the concentration of proteins in nearby solution. Here we present a theory of multi-step replacement of DNA-bound proteins by solution-phase proteins. For four different kinetic
Cocco, Simona, Marko, John F., Monasson, Remi   +2 more
core   +3 more sources

DNABP: Identification of DNA-Binding Proteins Based on Feature Selection Using a Random Forest and Predicting Binding Residues.

PLoS ONE, 2016
DNA-binding proteins are fundamentally important in cellular processes. Several computational-based methods have been developed to improve the prediction of DNA-binding proteins in previous years.
Xin Ma, Jing Guo, Xiao Sun
doaj   +1 more source

Predicting DNA-binding proteins and binding residues by complex structure prediction and application to human proteome.

PLoS ONE, 2014
As more and more protein sequences are uncovered from increasingly inexpensive sequencing techniques, an urgent task is to find their functions. This work presents a highly reliable computational technique for predicting DNA-binding function at the level
Huiying Zhao, Jihua Wang, Yaoqi Zhou, Yuedong Yang   +3 more
doaj   +1 more source

Acrylamide Capture of DNA-Bound Complexes: Electrophoretic Purification of Transcription Factors

BioTechniques, 2002
We have developed a rapid nonradioactive electrophoretic technique to analyze proteins within DNA-binding complexes, acrylamide capture of DNA-binding complexes (ACDC), using Acrydite™-linked DNA-binding targets. The method is highly sensitive and easily
Colleen Nelson, Stephen Hendy, Kim Reid, John Cavanagh   +3 more
doaj   +1 more source