Results 61 to 70 of about 1,985,752 (333)

Molecular mechanism underlying the interaction of typical Sac10b family proteins with DNA. [PDF]

PLoS ONE, 2012
The Sac10b protein family is regarded as a family of DNA-binding proteins that is highly conserved and widely distributed within the archaea. Sac10b family members are typically small basic dimeric proteins that bind to DNA with cooperativity and no ...
Yan-Feng Liu, Nan Zhang, Xi Liu, Xinquan Wang, Zhi-Xin Wang, Yuanyuan Chen, Hong-Wei Yao, Hong-Wei Yao, Meng Ge, Xian-Ming Pan   +9 more
doaj   +1 more source

Non-additivity in protein-DNA binding [PDF]

Bioinformatics, 2005
Localizing protein binding sites within genomic DNA is of considerable importance, but remains difficult for protein families, such as transcription factors, which have loosely defined target sequences. It is generally assumed that protein affinity for DNA involves additive contributions from successive nucleotide pairs within the target sequence. This
O'Flanagan, Ra, Paillard, G., Lavery, R., Sengupta, Am   +3 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates [PDF]

, 2010
Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 5'-flap.
Aguilera, Ayyagari, Bae, Bae, Bae, Balakrishnan, Bell, Bonetti, Budd, Budd, Budd, Budd, Budd, Budd, Ceska, Chapados, Dervan, Devos, Duxin, Garg, Harrington, Hohl, Hosfield, Jason A. Stewart, Judith L. Campbell, Kao, Kao, Kao, Kim, Kim, Lee, Liao, Liu, Liu, Liu, Masuda-Sasa, Masuda-Sasa, Mathews, Moser, Mueser, Murante, Qiu, Robert A. Bambara, Robertson, Shrader, Stewart, Stewart, Stewart, Szczesny, Weitao, Williams, Xu, Zheng, Zhu, Zuker   +54 more
core   +2 more sources

Comparative footprinting of DNA-binding proteins [PDF]

Bioinformatics, 2006
Abstract Motivation: Comparative modelling is a computational method used to tackle a variety of problems in molecular biology and biotechnology. Traditionally it has been applied to model the structure of proteins on their own or bound to small ligands, although more recently it has also been used to model protein-protein interfaces ...
Contreras-Moreira, Bruno, Collado-Vides, Julio   +1 more
openaire   +3 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Concerted Formation of Macromolecular \u3cem\u3eSuppressor-mutator\u3c/em\u3e Transposition Complexes [PDF]

, 1998
Transposition of the maize Suppressor-mutator (Spm) transposon requires two element-encoded proteins, TnpA and TnpD. Although there are multiple TnpA binding sites near each element end, binding of TnpA to DNA is not cooperative, and the binding affinity
Elhofy, Adam, Fedoroff, Nina V., Karunanandaa, Balasulojini, Raina, Ramesh, Schläppi, Michael   +4 more
core   +1 more source

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. [PDF]

, 2009
Transcription factor-DNA interactions are some of the most important processes in biology because they directly control hereditary information. The targets of most transcription factor are unknown.
Korf, Ian, Segal, David J, Zykovich, Artem   +2 more
core   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]

, 2012
Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core   +1 more source