Results 51 to 60 of about 665,876 (395)

The ability to form homodimers is essential for RDM1 to function in RNA-directed DNA methylation. [PDF]

PLoS ONE, 2014
RDM1 (RNA-DIRECTED DNA METHYLATION1) is a small plant-specific protein required for RNA-directed DNA methylation (RdDM). RDM1 interacts with RNA polymerase II (Pol II), ARGONAUTE4 (AGO4), and the de novo DNA methyltransferase DOMAINS REARRANGED ...
Taku Sasaki, Zdravko J Lorković, Shih-Chieh Liang, Antonius J M Matzke, Marjori Matzke   +4 more
doaj   +1 more source

A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases [PDF]

, 2011
Y-family DNA polymerases are characterized by low-fidelity synthesis on undamaged DNA and ability to catalyze translesion synthesis over the damaged DNA. Their translocation along the DNA template is an important event during processive DNA synthesis. In
A Alt, A Tissier, A Vaisman, AF Moon, AM DeLucia, AM DeLucia, AR Lehmann, BL Zhou, C Masutani, C Xu, CM Joyce, CW Gardiner, D Nair, DK Braithwaite, DT Nair, E Delagoutte, E Glick, E Ohashi, EC Friedberg, ER Kay, F Boudsocq, F Boudsocq, F Boudsocq, H Huang, H Ling, H Ling, H Ling, H Ling, H Ohmori, H Zang, IK Cann, J Trincao, J Trincao, J Wagner, J Yamtich, JD Pata, JH Wong, JR Nelson, K Datta, K Luby-Phelps, KA Fiala, KA Fiala, KA Fiala, LF Silvian, M Hogg, M Tang, MF Goodman, MJ Donlin, MO Magnasco, MT Washington, MT Washington, MT Washington, NB Reuven, NM Stano, O Potapova, O Rechkoblit, OI Kulaeva, P Gruz, P Xie, P Xie, P Xie, PEM Gibbs, Ping Xie, R Jain, R Vasquez-Del Carpio, R Woodgate, RC Wilson, RE Johnson, RE Johnson, RJ Kokoska, RJ Kokoska, RM Turner, S Doublie, S Moran, SD McCulloch, SN Uljon, W Yang, Y LI, Y LI   +78 more
core   +3 more sources

First-passage problems in DNA replication: effects of template tension on stepping and exonuclease activities of a DNA polymerase motor [PDF]

Journal of Physics: Condensed Matter, vol.25, 374105 (2013), 2013
A DNA polymerase (DNAP) replicates a template DNA strand. It also exploits the template as the track for its own motor-like mechanical movement. In the polymerase mode it elongates the nascent DNA by one nucleotide in each step. But, whenever it commits an error by misincorporating an incorrect nucleotide, it can switch to an exonuclease mode.
arxiv   +1 more source

The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography [PDF]

, 2000
Sporulation in Bacillus involves the induction of scores of genes in a temporally and spatially co-ordinated programme of cell development. Its initiation is under the control of an expanded two-component signal transduction system termed a phosphorelay.
Baldus J.M., Brown D.P., Buckner C.M., Buckner C.M., Busby S., Chung J.D., Cowtan K., Ferrari F.A., Fogh R.H., Green B.D., Grimsley J.K., Hatt J.K., Igarashi K., Ireton K., Kenney T.J., Kondo H., Kuldell N., Makino K., Martinez-Hackert E., Muchova K., Murshudov G.N., Olmedo G., Perego M., Satola S.W., Schyns G., Spiegelman G.B., Spiegelman G.B., Strauch M.A., Strauch M.A., Terwilliger T.C., Weir J., Wu H.-M., York K.   +32 more
core   +1 more source

RNA-directed DNA polymerase and virus-induced leukemia in mice.

Proceedings of the National Academy of Sciences of the United States of America, 1973
Rifamycin antibiotics, which inhibit RNA-directed DNA polymerase of Rauscher leuckemia virus, prevent the leukemogenic activity of the virus, and the effect of leukemogenesis correlates with the magnitude of inhibition of the purified enzyme.
A. Wu, R. Ting, R. Gallo
semanticscholar   +1 more source

Isolation and physical properties of the DNA‐directed RNA polymerase from Thermus thermophilus HB8 [PDF]

European Journal of Biochemistry, 1990
The DNA‐directed RNA polymerase from the extremely thermophilic eubacterium Thermus thermophilus HB8 was purified employing a new and rapid method. The subunit pattern of the enzyme, analyzed by SDS gel electrophoresis, was interpreted as: 140 kDa and 170 kDa for β and β′, 40 kDa for α and 92 kDa for ó.
Stephan Wnendt, Roland K. Hartmann, Norbert Ulbrich, Volker A. Erdmann   +3 more
openaire   +3 more sources

Stochastic resetting in backtrack recovery by RNA polymerases [PDF]

Phys. Rev. E 93, 062411 (2016), 2016
Transcription is a key process in gene expression, in which RNA polymerases produce a complementary RNA copy from a DNA template. RNA polymerization is frequently interrupted by backtracking, a process in which polymerases perform a random walk along the DNA template.
arxiv   +1 more source

T4 DNA polymerase improves the efficiency of multiple site-directed mutagenesis

Biotechnology & Biotechnological Equipment, 2016
Site-directed mutagenesis (SDM) is a useful tool to study the functions of regulatory sequences of DNA and RNA, and the structures and functions of proteins. Numerous methods have been developed for either single or multiple SDM (MSDM).
Wei Guo, Shuhui Sun, Binghua Xie, Xiao-Jing Zhu, Zhong-Min Dai   +4 more
doaj   +1 more source

RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. [PDF]

, 2012
In plants, heterochromatin is maintained by a small RNA-based gene silencing mechanism known as RNA-directed DNA methylation (RdDM). RdDM requires the non-redundant functions of two plant-specific DNA-dependent RNA polymerases (RNAP), RNAP IV and RNAP V.
Chen, Xuemei, Gurazada, Sai Guna Ranjan, Lee, Tzuu-fen, Li, Shengben, Matzke, Marjori A, Meyers, Blake C, Simon, Stacey A, Zhai, Jixian   +7 more
core   +2 more sources

Particles with RNA of high molecular weight and RNA-directed DNA polymerase in human brain tumors.

Proceedings of the National Academy of Sciences of the United States of America, 1973
We have previously shown that neoplastic cells of human breast cancers, leukemias, lymphomas, and sarcomas contain particles similar to the viruses that have been established as etiologic agents of these diseases in mice.
W. Cuatico, J. Cho, S. Spiegelman
semanticscholar   +1 more source