Results 81 to 90 of about 666,524 (370)

The Role OF DNA Polymerases in Carcinogenesis

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2016
Background and Objectives: The major role of various types of DNA polymerases is genome replication. However, DNA polymerases are also necessary to establish the accuracy, efficiency of replication, repairing process, and consequently decrease in ...
Zahra Aghelan, Mojtaba Panjehpour
doaj  

Tyrosines involved in the activity of φ29 single-stranded DNA binding protein.

PLoS ONE, 2019
The genome of Bacillus subtilis phage ϕ29 consists of a linear double-stranded DNA with a terminal protein (TP) covalently linked to each 5' end (TP-DNA).
Iván de la Torre, Victor Quiñones, Margarita Salas, Alicia Del Prado   +3 more
doaj   +1 more source

Selection of chromosomal DNA libraries using a multiplex CRISPR system. [PDF]

, 2014
The directed evolution of biomolecules to improve or change their activity is central to many engineering and synthetic biology efforts. However, selecting improved variants from gene libraries in living cells requires plasmid expression systems that ...
Arkin, Adam P, Cate, Jamie HD, DeLoache, Will, Dueber, John E, Lee, Michael E, Li, Xin, Maurer, Matthew J, Poddar, Snigdha, Ryan, Owen W, Skerker, Jeffrey M, Tsai, Jordan C   +10 more
core   +2 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]

, 2008
Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core   +2 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1

BMC Genetics, 2007
Background Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes.
DasSarma Shiladitya, DasSarma Priya, Berquist Brian R   +2 more
doaj   +1 more source

N 6-Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens

Chemical Science, 2015
N 6-Methyladenine (m6A) is the most abundant internal modification on mammalian mRNA. Very recently, m6A has been reported as a potentially important ‘epigenetic’ mark in eukaryotes.
Shaoru Wang, Jia-Qi Wang, Xiaoe Zhang, Bo-Shi Fu, Yanyan Song, Pei Ma, Kai Gu, Xin Zhou, Xiaolian Zhang, Tian Tian, Xiaoping Zhou   +10 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

RNA-directed DNA synthesis by the DNA polymerase of Rous sarcoma virus: structural and functional identification of 4S primer RNA in uninfected cells.

Proceedings of the National Academy of Sciences of the United States of America, 1975
The RNA-directed DNA polymerase of Rous sarcoma virus requires a 4S RNA molecule as primer for the initiation of DNA synthesis on the viral 70S RNA genome.
A. Faras, N. A. Dibble
semanticscholar   +1 more source