Results 181 to 190 of about 48,433 (280)

DNA polymerase ζ has robust reverse transcriptase activity relative to other cellular DNA polymerases. [PDF]

J Biol Chem
Mayle R, Holloman WK, O'Donnell ME.
europepmc   +1 more source

DNA-Directed RNA Polymerase III Subunit RPC2 [PDF]

, 2020
openaire   +1 more source

Cluster analysis of selected Mycobacterium species using rifampicin resistance DNA-directed RNA polymerase beta subunit (rpoB) gene

International Journal of Infectious Diseases, 2020
O. S. Amoo, F. Anwoju, I. Taiwo
openaire   +3 more sources

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist-Tsix locus. [PDF]

Nat Commun
Kesler BK, Adams J, Neuert G.
europepmc   +1 more source

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

Advanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li   +11 more
wiley   +1 more source

Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations. [PDF]

ACS Synth Biol
Chia BS, Seah YFS, Wang B, Shen K, Srivastava D, Chew WL.   +5 more
europepmc   +1 more source

Lack of sugar discrimination by human pol requires a single glycine residue [PDF]

, 2003
Blanco Dávila, Luis, Fernández de Henestrosa, Antonio R., García Díaz, Miguel, González Barrera, Sergio, Juárez, Raquel, Picher, Ángel J., Ruiz Pérez, José Francisco, Terrados, Gloria   +7 more
core   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Next-Generation Sequencing Methods to Determine the Accuracy of Retroviral Reverse Transcriptases: Advantages and Limitations. [PDF]

Viruses
Martínez Del Río J, Menéndez-Arias L.
europepmc   +1 more source