Results 31 to 40 of about 48,433 (280)

RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. [PDF]

open access: yes, 2012
In plants, heterochromatin is maintained by a small RNA-based gene silencing mechanism known as RNA-directed DNA methylation (RdDM). RdDM requires the non-redundant functions of two plant-specific DNA-dependent RNA polymerases (RNAP), RNAP IV and RNAP V.
Chen, Xuemei   +7 more
core   +2 more sources

Mechanical Properties of Transcription [PDF]

open access: yesPhys. Rev. Lett. 118, 268101 (2017), 2016
Recently the physical characterization of a number of biological processes has proven indispensable for a full understanding of natural phenomena. One such example is the mechanical properties of transcription, which have been shown to have significant effects in gene expression.
arxiv   +1 more source

Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]

open access: yes, 2017
Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a B400 kDa five-subunit catalytic core.
Forrest, David   +3 more
core   +2 more sources

The first peptides: the evolutionary transition between prebiotic amino acids and early proteins [PDF]

open access: yes, 2009
The issues we attempt to tackle here are what the first peptides did look like when they emerged on the primitive earth, and what simple catalytic activities they fulfilled.
Buhrman, Harry   +4 more
core   +5 more sources

Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]

open access: yes, 2015
Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty   +17 more
core   +1 more source

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages.

open access: yesPLoS Biology, 2015
Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Peter Sarkies   +14 more
doaj   +1 more source

Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]

open access: yes, 2016
Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen   +2 more
core   +1 more source

Uncovering the effect of RNA polymerase steric interactions on gene expression noise: analytical distributions of nascent and mature RNA numbers [PDF]

open access: yesarXiv, 2023
The telegraph model is the standard model of stochastic gene expression, which can be solved exactly to obtain the distribution of mature RNA numbers per cell. A modification of this model also leads to an analytical distribution of the nascent RNA numbers. These solutions are routinely used for the analysis of single-cell data, including the inference
arxiv  

Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function [PDF]

open access: yes, 2017
We thank Andres Aguilera for providing the pCYC-LacZ plasmid for the GLRO experiments, and Szilvia Minorits for technical assistance. This work was also supported by grants from the National Research, Development and Innovation Office: GINOP-2.3.2-15 ...
Balint, Eva   +5 more
core   +3 more sources

Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates [PDF]

open access: yes, 2013
Nonhomologous end-joining (NHEJ) pathways repair DNA double-strand breaks (DSBs) in eukaryotes and many prokaryotes, although it is not reported to operate in the third domain of life, archaea. Here, we describe a complete NHEJ complex, consisting of DNA
Bartlett, Edward   +2 more
core   +1 more source

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