Results 131 to 140 of about 4,247,719 (263)

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Electron acceptors modulate methane oxidation and active methanotrophic communities in anoxic urban wetland sediments

Applied and Environmental Microbiology
Urban wetlands, although often overlooked, are hotspots for CH4 cycling. However, the understanding of anaerobic CH4 oxidation and microbial responses to different electron acceptors in urban wetlands remains limited. Here, we employed DNA-stable isotope
Ruiyu Yang, Chao Peng, Yongliang Mo, Sara Kleindienst, Shun Li, Jiajia Wang, Andreas Kappler, Zimeng Wang, Lu Lu   +8 more
doaj   +1 more source

Using MALDI‐FTICR Mass Spectrometry to Enhance ZooMS Identifications of Pleistocene Bone Fragments Showing Variable Collagen Preservation

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Recent advances in high‐throughput molecular analyses of collagen peptides, especially ZooMS (Zooarchaeology by Mass Spectrometry), have permitted breakthroughs in the analysis of archaeological material that is highly fragmented, a factor that hinders morphological identification.
Pauline Raymond, Karen Ruebens, Fabrice Bray, Jean‐Christophe Castel, Eugène Morin, Foni Le Brun‐Ricalens, Jean‐Guillaume Bordes, Christian Rolando, Jean‐Jacques Hublin   +8 more
wiley   +1 more source

Identification of the bacterial community that degrades phenanthrene sorbed to polystyrene nanoplastics using DNA-based stable isotope probing

Scientific Reports
In the Anthropocene, plastic pollution has become a new environmental biotope, the so-called plastisphere. In the oceans, nano- and micro-sized plastics are omnipresent and found in huge quantities throughout the water column and sediment, and their ...
Stephen Summers, Mohammad Sufian Bin-Hudari, Clayton Magill, Theodore Henry, Tony Gutierrez   +4 more
doaj   +1 more source

Rational design of a lipophilic β‐galactosidase‐responsive near‐infrared probe for in vivo imaging of cellular senescence

Smart Molecules, EarlyView.
We developed a lipophilic near‑infrared probe (DCIP‑AcGal) that is specifically activated by senescence‑associated β‑galactosidase. After intravenous injection, it lights up therapy‑induced tumor senescence in living mice. Its optimized lipophilicity also enables blood‑brain barrier crossing to detect natural brain senescence ex vivo. This probe offers
Jiani Huang, Feiyi Chu, Bin Feng, Lin Chen, Peili Cen, Jing Wang, Ying Qu, Lu Hong, Fei Wu, Huanfeng Tian, Yanpeng Fang, Yuanjie Chen, Mei Tian, Wenbin Zeng, Hong Zhang, Yan Zhong   +15 more
wiley   +1 more source

Stable-isotope probing implicates Methylophaga spp and novel Gammaproteobacteria in marine methanol and methylamine metabolism

, 2007
The metabolism of one-carbon (C-1) compounds in the marine environment affects global warming, seawater ecology and atmospheric chemistry. Despite their global significance, marine microorganisms that consume C-1 compounds in situ remain poorly ...
Schäfer, Hendrik, Ian R McDonald, Murrell, J. C. (J. Colin), Michael J Cox, Neufeld, Josh D, McDonald, Ian R, J Colin Murrell, Josh D Neufeld, Cox, Michael J., Murrell, J Colin, Rich Boden, Cox, Michael J; id_orcid, McDonald, Ian R., Boden, Rich, Neufeld, Josh D., Hendrik Schäfer   +15 more
core   +1 more source

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Smart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu, Xuejian Wang, Bangjian Li, Kun Shao, Jianlong Su, Yang Wang, Lin Cheng, Zhihao Wu, JinRong Li, Guanyi Zhang, Xu Wang, Yuxuan Zhang, Yuanhao Liu, Guangzhe Li   +13 more
wiley   +1 more source

Ontogeny of foraging behaviour in an opportunistic gull inhabiting urban marine ecosystems

Wildlife Biology, EarlyView.
Urbanization affects ecosystems by reducing biodiversity and displacing species from native habitats. While some suffer, others, like urban wildlife, adapt through innovative feeding and behaviours that improve their fitness in human‐altered settings. Despite research on wildlife in urban areas, the development of foraging behaviour in urban species is
Joan Navarro, Víctor Martín-Vélez, Joan Giménez, José Antonio Garcia, Pablo Cermeño, Jordi Figuerola, Raül Aymí, Tomás Montalvo   +7 more
wiley   +1 more source

Interactions between prairie dogs and arthropods in grassland ecosystems: a review and research gaps

Wildlife Biology, EarlyView.
Prairie dogs (Cynomys spp.) are an important component of grassland ecosystems of North America where they can alter vegetation composition/structure and physical attributes of grassland habitats through their feeding and burrowing behavior. Impacts of prairie dog presence on many wildlife and plant taxa have been widely studied but research on prairie
Joshua W. Campbell, Alexandra Tsalickis, Ellen A. R. Welti, Itai Namir   +3 more
wiley   +1 more source

Bridging the divide between models of animal‐driven and microbial‐driven biogeochemical cycling: A zoogeochemistry‐informed framework

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Most current terrestrial biogeochemical models formalize biogeochemical cycling as predominantly controlled by processes involving plants and soil microbes. However, growing evidence indicates that above‐ground animals could exert controlling feedback effects that alter
Janey R. Lienau, Nathalie R. Sommer, Oswald J. Schmitz   +2 more
wiley   +1 more source