Results 141 to 150 of about 4,247,719 (263)

Structural Problems are Solvable Problems: Working Together to Prevent Health Inequities With a Structural Vulnerability Approach

American Anthropologist, EarlyView.
ABSTRACT Anthropologists have long grappled with how to analyze the structural production of harm. Foundational formulations of structural violence demonstrated how social forces became embodied as disparities in health and survival but were difficult to operationalize across anthropological subdisciplines.
Meredith G. Marten, Paula Skye Tallman, Allysha P. Winburn, Katherine A. Miller Wolf, Jennifer F. Byrnes, Benjamin R. Burgen, Robin C. Reineke, Jaymelee J. Kim, Claire L. Wendland   +8 more
wiley   +1 more source

DNA Stable-Isotope Probing Delineates Carbon Flows from Rice Residues into Soil Microbial Communities Depending on Fertilization. [PDF]

Appl Environ Microbiol, 2020
Kong Y, Kuzyakov Y, Ruan Y, Zhang J, Wang T, Wang M, Guo S, Shen Q, Ling N.   +8 more
europepmc   +1 more source

MISIP: a data standard for the reuse and reproducibility of any stable isotope probing-derived nucleic acid sequence and experiment [PDF]

DNA/RNA-stable isotope probing (SIP) is a powerful tool to link in situ microbial activity to sequencing data. Every SIP dataset captures distinct information about microbial community metabolism, process rates, and population dynamics, offering valuable
Kimbrel, Jeffrey A, Walls, Ramona L, Schriml, Lynn M, Wilhelm, Roland C, Simpson, Abigayle, Hunter, Christopher I, Smith, Montana, Beilsmith, Kathleen, Kellom, Matthew, Wood-Charlson, Elisha M, Koch, Benjamin J   +10 more
core   +1 more source

From Model to Practice: Testing Near‐Infrared Spectroscopy as a Bone Collagen Prescreening Tool

Archaeometry, EarlyView.
ABSTRACT Collagen is a vital archaeological material, preserving biochemical signatures that provide insights into past environments, diets, and human–animal interactions. However, diagenetic processes can lead to rapid and often inconspicuous degradation of collagen. Given the variability in collagen preservation and its significance for analyses such
Christina Ryder, Gerardo Celis, Thibaut Devièse, Thomas Higham, Katerina Douka, Loren Davis, Matthew Collins, Angela Perri, Heather Thakar, Matt Sponheimer   +9 more
wiley   +1 more source

DNA Stable Isotope Probing Mehod to Examine Carbon Assimilation in Stream Biofilms

, 2017
DNA stable isotope probing (DNA-SIP) identifies microbial populations that assimilate a substrate of interest by tracking the movement of an isotopic label from a substrate into DNA. Although the technique has not been widely used in streams, DNA-SIP can
Aanderud, Zachary, Baker, Michelle, Ogata, Beth, Uday, Sandra   +3 more
core   +1 more source

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

DNA STABLE ISOTOPE PROBING METHODS TO EXAMINE CARBON ASSIMILATION IN STREAM BIOFILMS

, 2017
DNA stable isotope probing (DNA-SIP) identifies microbial populations that assimilate a substrate of interest by tracking the movement of an isotopic label from a substrate into DNA. Although the technique has not been widely used in streams, DNA-SIP can
Aanderud, Zachary, Ogata, Elizabeth, Baker, Michelle, Udy, Sandra   +3 more
core   +1 more source

An inhibitor of the mitochondrial respiratory chain exerts synergistic anti‐tumour effects when combined with alkylating agents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cancer cells exhibit the Warburg effect, but oxidative phosphorylation (OXPHOS) is also important for cancer cell proliferation. Metabolic reprogramming from glycolysis to OXPHOS is one mechanism of resistance to anti‐tumour drugs.
Emiri Omori Takaki, Yuya Hidoh, Yutaka Obuchi, Yoko Nagai, Shingo Nishikori, Yuki Kuniyoshi, Yasuhiro Sawai, Naoto Ohi   +7 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

The molecular basis of GshT substrate binding reveals how Streptococcus pneumoniae acquires the antioxidant glutathione

The FEBS Journal, EarlyView.
Streptococcus pneumoniae imports glutathione (GSH) from its obligate human host to defend against oxidative stress. GSH import is facilitated through the substrate binding protein (SBP) GshT, relying on charge complementarity between the protein and ligand.
Sarah E. du Toit, Paul E. Pace, Pierre De Cordovez, Christoph Göbl, Nina Dickerhof   +4 more
wiley   +1 more source