Results 11 to 20 of about 6,778,475 (339)

DNA methylation and DNA methyltransferases [PDF]

Epigenetics & Chromatin, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +9 more sources

Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics

mAbs, 2022
Rapid release of biopharmaceutical products enables a more efficient drug manufacturing process. Multi-attribute methods that target several product quality attributes (PQAs) at one time are an essential pillar of the rapid-release strategy.
Bingchuan Wei, Nicholas Woon, Lu Dai, Raphael Fish, Michelle Tai, Winode Handagama, Ashley Yin, Jia Sun, Andrew Maier, Dana McDaniel, Elvira Kadaub, Jessica Yang, Miguel Saggu, Ann Woys, Oxana Pester, Danny Lambert, Alex Pell, Zhiqi Hao, Gordon Magill, Jack Yim, Jefferson Chan, Lindsay Yang, Frank Macchi, Christian Bell, Galahad Deperalta, Yan Chen   +25 more
doaj   +1 more source

IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans

Microbiome, 2023
Background IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial cell differentiation and ...
Jordan S. Mar, Naruhisa Ota, Nick D. Pokorzynski, Yutian Peng, Allan Jaochico, Dewakar Sangaraju, Elizabeth Skippington, Annemarie N. Lekkerkerker, Michael E. Rothenberg, Man-Wah Tan, Tangsheng Yi, Mary E. Keir   +11 more
doaj   +1 more source

Cleaving DNA with DNA [PDF]

Proceedings of the National Academy of Sciences, 1998
A DNA structure is described that can cleave single-stranded DNA oligonucleotides in the presence of ionic copper. This “deoxyribozyme” can self-cleave or can operate as a bimolecular complex that simultaneously makes use of duplex and triplex interactions to bind and cleave separate DNA substrates.
N, Carmi, S R, Balkhi, R R, Breaker
openaire   +2 more sources

Phosphorylating DNA with DNA [PDF]

Proceedings of the National Academy of Sciences, 1999
Nearly 50 individual DNAs with polynucleotide kinase-like activity were isolated from a random-sequence pool by using in vitro selection. Each self-phosphorylating deoxyribozyme makes use of one or more of the eight standard NTPs or dNTPs as a source of activated phosphate.
Y, Li, R R, Breaker
openaire   +2 more sources

Optimized design parameters for CRISPR Cas9 and Cas12a homology-directed repair

Scientific Reports, 2021
CRISPR–Cas proteins are RNA-guided nucleases used to introduce double-stranded breaks (DSBs) at targeted genomic loci. DSBs are repaired by endogenous cellular pathways such as non-homologous end joining (NHEJ) and homology-directed repair (HDR ...
Mollie S. Schubert, Bernice Thommandru, Jessica Woodley, Rolf Turk, Shuqi Yan, Gavin Kurgan, Matthew S. McNeill, Garrett R. Rettig   +7 more
doaj   +1 more source

Overall survival in patients with advanced non-small cell lung cancer with KRAS G12C mutation with or without STK11 and/or KEAP1 mutations in a real-world setting

BMC Cancer, 2023
Background KRAS mutations occur frequently in advanced non-small cell lung cancer (aNSCLC); the G12C mutation is the most prevalent. Alterations in STK11 or KEAP1 commonly co-occur with KRAS mutations in aNSCLC.
Cristina Julian, Navdeep Pal, Anda Gershon, Marie Evangelista, Hans Purkey, Peter Lambert, Zhen Shi, Qing Zhang   +7 more
doaj   +1 more source

Plant GARDEN: a portal website for cross-searching between different types of genomic and genetic resources in a wide variety of plant species

BMC Plant Biology, 2023
Background Plant genome information is fundamental to plant research and development. Along with the increase in the number of published plant genomes, there is a need for an efficient system to retrieve various kinds of genome-related information from ...
Hisako Ichihara, Manabu Yamada, Mitsuyo Kohara, Hideki Hirakawa, Andrea Ghelfi, Takuro Tamura, Akihiro Nakaya, Yasukazu Nakamura, Sachiko Shirasawa, Samatchaya Yamashita, Yosuke Toda, Daijiro Harada, Tsunakazu Fujishiro, Akiko Komaki, Jeffrey A. Fawcett, Eiji Sugihara, Satoshi Tabata, Sachiko N. Isobe   +17 more
doaj   +1 more source

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy

Genome Medicine, 2023
Background Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities ...
Zia Khan, Min Jung, Megan Crow, Rajat Mohindra, Vidya Maiya, Joshua S. Kaminker, David H. Hackos, G. Scott Chandler, Mark I. McCarthy, Tushar Bhangale   +9 more
doaj   +1 more source

Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination [PDF]

Proceedings of the National Academy of Sciences, 2001
Two important and timely questions with respect to DNA replication, DNA recombination, and DNA repair are: ( i ) what controls which DNA polymerase gains access to a particular primer-terminus, and ( ii ) what determines whether a DNA polymerase hands off its DNA substrate to either a ...
M D, Sutton, G C, Walker
openaire   +2 more sources