Results 21 to 30 of about 6,270,915 (209)

Self-replication and evolution of DNA crystals [PDF]

, 2005
Is it possible to create a simple physical system that is capable of replicating itself? Can such a system evolve interesting behaviors, thus allowing it to adapt to a wide range of environments?
A.G. Cairns-Smith, A.G. Cairns-Smith, C. Mao, E. Winfree, E. Winfree, E. Winfree, H.-L. Chen, J.H. Reif, J.H. Reif, L.M. Adleman, L.M. Adleman, M. Eigen, N. Chelyapov, P.W.K. Rothemund, R. Schulman, T.-J. Fu, T.H. LaBean   +16 more
core   +2 more sources

A record of the Porbeagle, Lamna nasus, in coastal waters of Buenos Aires (Argentina) confirmed by DNA barcoding [PDF]

, 2015
A record of a juvenile Porbeagle, Lamna nasus, in the coastal waters of Argentina is confirmed by DNA barcoding, since the specimen lacked some external diagnostic features.
Díaz de Astarloa, Juan Martín, Lucifora, Luis Omar, Mabragaña, Ezequiel   +2 more
core   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

Nature Communications, 2020
The RNase activity of Inositol-Requiring Enzyme 1 (IRE1) can be allosterically regulated by ATP-competitive inhibitors of the IRE1 kinase domain. Here, the authors identify ATP-competitive IRE1 RNase activators with improved selectivity and cellular ...
Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang   +17 more
doaj   +1 more source

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. [PDF]

, 2018
Type IIA topoisomerases (Top2s) manipulate the handedness of DNA crossovers by introducing a transient and protein-linked double-strand break in one DNA duplex, termed the DNA-gate, whose opening allows another DNA segment to be transported through to ...
Chan, Nei-Li, Chen, Shin-Fu, Gilson, Michael K, Huang, Nan-Lan, Lin, Jung-Hsin, Wang, Ying-Ren, Wu, Chyuan-Chuan, Yu, Yu-Jen   +7 more
core   +2 more sources

Author Correction: Artificial neural network, predictor variables and sensitivity threshold for DNA methylation-based age prediction using blood samples

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Zhonghui Thong, Jolena Ying Ying Tan, Eileen Shuzhen Loo, Yu Wei Phua, Xavier Liang Shun Chan, Christopher Kiu-Choong Syn   +5 more
doaj   +1 more source

Cyclization of Short DNA Fragments [PDF]

Physica A482, 569 (2017), 2017
From the per unit length free energy for DNA under tension, we have calculated an effective contour length dependent persistence length for short DNA. This effective persistence length results from the enhanced fluctuations in short DNA. It decreases for shorter DNA, making shorter DNA more flexible.
arxiv   +1 more source

FlavonoidSearch: A system for comprehensive flavonoid annotation by mass spectrometry

Scientific Reports, 2017
Currently, in mass spectrometry-based metabolomics, limited reference mass spectra are available for flavonoid identification. In the present study, a database of probable mass fragments for 6,867 known flavonoids (FsDatabase) was manually constructed ...
Nayumi Akimoto, Takeshi Ara, Daisuke Nakajima, Kunihiro Suda, Chiaki Ikeda, Shingo Takahashi, Reiko Muneto, Manabu Yamada, Hideyuki Suzuki, Daisuke Shibata, Nozomu Sakurai   +10 more
doaj   +1 more source

Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion [PDF]

, 2005
Type IB DNA topoisomerases cleave and rejoin one strand of the DNA duplex, allowing for the removal of supercoils generated during replication and transcription.
Dekker, Cees, Dekker, Nynke H., Holtzer, Laurent, Koster, Daniel A., Moreno-Herrero, Fernando, Shuman, Stewart   +5 more
core   +2 more sources

Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]

, 2020
DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan, Keszthelyi, Andrea, Minchell, Nicola Elizabeth   +2 more
core   +1 more source