Results 21 to 30 of about 6,548,876 (337)
Genome Medicine, 2023 Background Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities ...
Zia Khan +9 more
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Comunicação e Sociedade, 2012 El presente artículo se entiende dentro de una interesante iniciativa promovida por la Universidad do Minho que vio la luz por primera vez en octubre de 2004. El I Seminario Internacional de Comunicación Persuasiva planteó una cuestión más que relevante:
Dña. Charo Sádaba
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Linear DNA amplicons as a novel cancer vaccine strategy
Journal of Experimental & Clinical Cancer Research, 2022 Background DNA-based vaccines represent a simple, safe and promising strategy for harnessing the immune system to fight infectious diseases as well as various forms of cancer and thus are considered an important tool in the cancer immunotherapy toolbox ...
Antonella Conforti +11 more
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BMC Plant Biology, 2021 Bacterial canker of tomato (Solanum lycopersicon) caused by the Gram-positive bacterium Clavibacter michiganensis subsp. michiganensis (Cmm) is an economically important disease.
Naoki Yokotani +8 more
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Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion [PDF]
, 2005 Type IB DNA topoisomerases cleave and rejoin one strand of the DNA duplex, allowing for the removal of supercoils generated during replication and transcription.
Dekker, Cees +5 more
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Scientific Reports, 2022 Carrot is a major source of provitamin A in a human diet. Two of the most important traits for carrot breeding are carotenoid contents and root color.
Taeko Shibaya +8 more
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Nature Reviews Methods Primers, 2021 Biological materials are self-assembled with near-atomic precision in living cells, whereas synthetic 3D structures generally lack such precision and controllability. Recently, DNA nanotechnology, especially DNA origami technology, has been useful in the bottom-up fabrication of well-defined nanostructures ranging from tens of nanometres to sub ...
Swarup Dey +11 more
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins [PDF]
, 2019 Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human DNA damage response (DDR) genes ...
Aguilera López, Andrés +5 more
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The C Terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit [PDF]
, 1999 Ku is a heterodimeric protein with double-stranded DNA end-binding activity that operates in the process of nonhomologous end joining. Ku is thought to target the DNA-dependent protein kinase (DNA-PK) complex to the DNA and, when DNA bound, can interact ...
Jeggo, P A +4 more
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Science, 2016 A long-sought protein that helps to break DNA is finally discovered [Also see Research Articles by Vrielynck et al. and Robert et al. ]
Claeys Bouuaert, Corentin, Keeney, Scott
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