Results 21 to 30 of about 5,185,708 (294)
DNA supercoiling inhibits DNA knotting [PDF]
Nucleic Acids Research, 2008 Despite the fact that in living cells DNA molecules are long and highly crowded, they are rarely knotted. DNA knotting interferes with the normal functioning of the DNA and, therefore, molecular mechanisms evolved that maintain the knotting and catenation level below that which would be achieved if the DNA segments could pass randomly through each ...
Burnier Y, Dorier J, Stasiak A
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FlavonoidSearch: A system for comprehensive flavonoid annotation by mass spectrometry
Scientific Reports, 2017 Currently, in mass spectrometry-based metabolomics, limited reference mass spectra are available for flavonoid identification. In the present study, a database of probable mass fragments for 6,867 known flavonoids (FsDatabase) was manually constructed ...
Nayumi Akimoto +10 more
doaj +1 more source
DNA methylation and DNA methyltransferases [PDF]
Epigenetics & Chromatin, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding mammalian genes was believed to be at least five times greater than the actual number, and when it was ...
John R. Edwards +3 more
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DNA methylation age of human tissues and cell types
Genome Biology, 2013 It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure.
S. Horvath
semanticscholar +1 more source
, 2011 DNA-DNA hybridization (DDH) techniques have been used as the gold standard for the genomic similarity analyses of pair-wise sets of strains for classification purposes. The method has had an enormous relevance during the last half a century of classification of prokaryotes.
Rosselló-Mora, Ramón +2 more
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DNA knots and DNA supercoiling [PDF]
Cell Cycle, 2011 Keywords: DNA topoisomerases; DNA topology; DNA structure Reference EPFL-ARTICLE-167094doi:10.4161/cc.10.9.15293View record in Web of Science Record created on 2011-06-24, modified on 2017-05 ...
Guillaume, Witz +2 more
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High cell-surface density of HER2 deforms cell membranes
Nature Communications, 2016 HER2 is frequently overexpressed in breast cancer in association with increased metastatic potential. Here, the authors show that HER2 overexpression causes deformation of cell membranes in a signalling-independent manner that contributes to the disease ...
Inhee Chung +8 more
doaj +1 more source
AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines
Nature Communications, 2021 The utility of AsCas12a can be limited to poor editing efficiency. Here the authors identify a variant, “AsCas12a Ultra”, that has high on-target specificity demonstrated through editing of clinically relevant T cell genes.
Liyang Zhang +23 more
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BioTechniques, 2000 An oligonucleotide labeling system was developed that can produce radiolabeled hybridization probes with tenfold or more higher specific activity than is obtained by traditional 5¢-end-labeling with polynucleotide kinase.
M.A. Behlke +5 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source