Results 31 to 40 of about 6,270,915 (209)

Tumor suppressor p53 binds with high affinity to CTG-CAG trinucleotide repeats and induces topological alterations in mismatched duplexes [PDF]

, 2005
DNA binding is central to the ability of p53 to function as a tumor suppressor. In line with the remarkable functional versatility of p53, which can act on DNA as a transcription, repair, recombination, replication, and chromatin accessibility factor ...
Ahn, Albertoni, Albrechtsen, Appella, Attardi, Bacolla, Bakalkin, Bakkenist, Bargonetti, Bowater, Cain, Chattopadhyay, Chi, Degtyareva, Dudenhoffer, el-Deiry, Espinosa, Giaccia, Gohler, Gohler, Gottifredi, Grillo, Hou, Hupp, Jayaraman, Jett, Kaeser, Kim, Kim, Kim, Kim, Kovtun, Lahiri, Lee, Lee, Li, Liu, Lowndes, Mateu, McKinney, Milyavsky, Mitas, Motoyama, Nakamura, Nie, Oberosler, Pearson, Pearson, Pearson, Petruska, Robles, Rosche, Rowan, Saito, Sinden, Stansel, Steffan, Steffen, Stros, Subramanian, Subramanian, Suck, Vogelstein, Vukojevic, Wahl, Wang, Wells, Wells, Wiesmuller, Wolcke, Zauberman, Zheng, Zhou, Zink   +73 more
core   +1 more source

High cell-surface density of HER2 deforms cell membranes

Nature Communications, 2016
HER2 is frequently overexpressed in breast cancer in association with increased metastatic potential. Here, the authors show that HER2 overexpression causes deformation of cell membranes in a signalling-independent manner that contributes to the disease ...
Inhee Chung, Mike Reichelt, Lily Shao, Robert W. Akita, Hartmut Koeppen, Linda Rangell, Gabriele Schaefer, Ira Mellman, Mark X. Sliwkowski   +8 more
doaj   +1 more source

Elongation/Compaction of Giant DNA Caused by Depletion Interaction with a Flexible Polymer [PDF]

, 2005
Structural changes in giant DNA induced by the addition of the flexible polymer PEG were examined by the method of single-DNA observation. In dilute DNA conditions, individual DNA assumes a compact state via a discrete coil-globule transition, whereas in concentrated solution, DNA molecules exhibit an extended conformation via macroscopic phase ...
arxiv   +1 more source

MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner

Journal for ImmunoTherapy of Cancer, 2019
Background One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface.
Changchun Du, Jack Bevers, Ryan Cook, T. Noelle Lombana, Kamalakannan Rajasekaran, Marissa Matsumoto, Christoph Spiess, Jeong M. Kim, Zhengmao Ye   +8 more
doaj   +1 more source

Quantitative mechanisms of DNA damage sensing and signaling

, 2020
DNA damage occurs abundantly during normal cellular proliferation. This necessitates that cellular DNA damage response and checkpoint pathways monitor the cellular DNA damage load and that DNA damage signaling is quantitative.
Bantele, S., Pfander, B.
core   +1 more source

From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions [PDF]

, 2009
©2009 Gao, Skolnick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Sarai, AV Morozov, BW Matthews, BW Matthews, CG Kalodimos, CH Yan, CO Pabo, E Fraenkel, E Katchalski-Katzir, FK Winkler, H Tjong, I Bonnet, IB Kuznetsov, Ilya Vakser, J Gorman, J Skolnick, J Skolnick, JE Donald, Jeffrey Skolnick, JJ Havranek, JS Lamoureux, JS Lamoureux, M Billeter, M Gao, M van Dijk, MJ Sippl, Mu Gao, N Bhardwaj, NC Horton, NM Luscombe, NP Stanford, O Givaty, P Aloy, P Rotkiewicz, PH von Hippel, R Mendez, R Samudrala, RMA Knegtel, S Ahmad, S Jones, SE Halford, SJ Hubbard, TA Robertson, TW Siggers, W Humphrey, WJ Lane, XJ Lu, Y Zhang, Y Zhang, ZJ Liu   +49 more
core   +4 more sources

Use of High Specific Activity StarFire™ Oligonucleotide Probes to Visualize Low-Abundance Pre-mRNA Splicing Intermediates in S. pombe

BioTechniques, 2000
An oligonucleotide labeling system was developed that can produce radiolabeled hybridization probes with tenfold or more higher specific activity than is obtained by traditional 5¢-end-labeling with polynucleotide kinase.
M.A. Behlke, S.A. Dames, W.H. McDonald, K.L. Gould, E.J. Devor, J.A. Walder   +5 more
doaj   +1 more source

DMSO Improves the Ski-Slope Effect in Direct PCR

Applied Sciences, 2021
Analytical techniques such as DNA profiling are widely used in various fields, including forensic science, and novel technologies such as direct polymerase chain reaction (PCR) amplification are continuously being developed in order to acquire DNA ...
Joo-Young Kim, Ju Yeon Jung, Da-Hye Kim, Seohyun Moon, Won-Hae Lee, Byung-Won Chun, Dong-Ho Choi   +6 more
doaj   +1 more source

Hakka Indenture Museum [PDF]

, 2017
https://openscholarship.wustl.edu/bcs/1362/thumbnail ...
., DnA
core   +1 more source

Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Nature Communications, 2019
Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.
Yu Kong, Christopher M. Rose, Ashley A. Cass, Alexander G. Williams, Martine Darwish, Steve Lianoglou, Peter M. Haverty, Ann-Jay Tong, Craig Blanchette, Matthew L. Albert, Ira Mellman, Richard Bourgon, John Greally, Suchit Jhunjhunwala, Haiyin Chen-Harris   +14 more
doaj   +1 more source