Results 31 to 40 of about 6,548,876 (337)

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

Nature Communications, 2020
The RNase activity of Inositol-Requiring Enzyme 1 (IRE1) can be allosterically regulated by ATP-competitive inhibitors of the IRE1 kinase domain. Here, the authors identify ATP-competitive IRE1 RNase activators with improved selectivity and cellular ...
Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang   +17 more
doaj   +1 more source

Helical Chirality: a Link between Local Interactions and Global Topology in DNA [PDF]

, 2010
DNA supercoiling plays a major role in many cellular functions. The global DNA conformation is however intimately linked to local DNA-DNA interactions influencing both the physical properties and the biological functions of the supercoiled molecule ...
A Minsky, A Stasiak, A Travers, AA Kornyshev, AA Travers, AA Vetcher, AK McClendon, AV Vologodskii, AV Vologodskii, BF Eichman, C Brochier-Armanet, CJ Benham, DE Pulleyblank, DI Cherny, DM Lilley, E Marguet, EL Zechiedrich, F Charbonnier, FH Crick, G Charvin, H Wong, HM Berman, IG Panyutin, J Yan, JC Wang, JF Marko, KC Dong, KC Neuman, KD Corbett, KD Corbett, L Postow, LF Liu, LS Shlyakhtenko, LS Shlyakhtenko, M Graille, M Kampmann, MD Stone, N Nöllmann, NJ Crisona, O Espeli, O Guipaud, P Forterre, P Forterre, P Lopez-Garcia, P Lopez-Garcia, P Várnai, PJJ Robinson, Péter Várnai, R Kanaar, R Lavery, S Inoue, S Shaw, S Trigueros, SS Zakharova, Stefan Wölfl, T Bankhead, T Schalch, T Schlick, T Stuchinskaya, TR Strick, V Katrich, V Stupina, VV Rybenkov, W Humphrey, WK Olson, WL DeLano, X Qiu, Y Timsit, Y Timsit, Y Timsit, Y Timsit, Y Timsit, Y Timsit, Y-C Xu, Youri Timsit, Z Liu, ZJ Tan   +76 more
core   +7 more sources

DNA knots and DNA supercoiling [PDF]

Cell Cycle, 2011
Keywords: DNA topoisomerases; DNA topology; DNA structure Reference EPFL-ARTICLE-167094doi:10.4161/cc.10.9.15293View record in Web of Science Record created on 2011-06-24, modified on 2017-05 ...
Andrzej Stasiak, Giovanni Dietler, Guillaume Witz   +2 more
openaire   +3 more sources

Author Correction: Artificial neural network, predictor variables and sensitivity threshold for DNA methylation-based age prediction using blood samples

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Zhonghui Thong, Jolena Ying Ying Tan, Eileen Shuzhen Loo, Yu Wei Phua, Xavier Liang Shun Chan, Christopher Kiu-Choong Syn   +5 more
doaj   +1 more source

CRISPAltRations: A validated cloud-based approach for interrogation of double-strand break repair mediated by CRISPR genome editing

Molecular Therapy: Methods & Clinical Development, 2021
CRISPR systems enable targeted genome editing in a wide variety of organisms by introducing single- or double-strand DNA breaks, which are repaired using endogenous molecular pathways.
Gavin Kurgan, Rolf Turk, Heng Li, Nathan Roberts, Garrett R. Rettig, Ashley M. Jacobi, Lauren Tso, Morgan Sturgeon, Massimo Mertens, Roel Noten, Kurt Florus, Mark A. Behlke, Yu Wang, Matthew S. McNeill   +13 more
doaj   +1 more source

From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions [PDF]

, 2009
©2009 Gao, Skolnick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Sarai, AV Morozov, BW Matthews, BW Matthews, CG Kalodimos, CH Yan, CO Pabo, E Fraenkel, E Katchalski-Katzir, FK Winkler, H Tjong, I Bonnet, IB Kuznetsov, Ilya Vakser, J Gorman, J Skolnick, J Skolnick, JE Donald, Jeffrey Skolnick, JJ Havranek, JS Lamoureux, JS Lamoureux, M Billeter, M Gao, M van Dijk, MJ Sippl, Mu Gao, N Bhardwaj, NC Horton, NM Luscombe, NP Stanford, O Givaty, P Aloy, P Rotkiewicz, PH von Hippel, R Mendez, R Samudrala, RMA Knegtel, S Ahmad, S Jones, SE Halford, SJ Hubbard, TA Robertson, TW Siggers, W Humphrey, WJ Lane, XJ Lu, Y Zhang, Y Zhang, ZJ Liu   +49 more
core   +4 more sources

FlavonoidSearch: A system for comprehensive flavonoid annotation by mass spectrometry

Scientific Reports, 2017
Currently, in mass spectrometry-based metabolomics, limited reference mass spectra are available for flavonoid identification. In the present study, a database of probable mass fragments for 6,867 known flavonoids (FsDatabase) was manually constructed ...
Nayumi Akimoto, Takeshi Ara, Daisuke Nakajima, Kunihiro Suda, Chiaki Ikeda, Shingo Takahashi, Reiko Muneto, Manabu Yamada, Hideyuki Suzuki, Daisuke Shibata, Nozomu Sakurai   +10 more
doaj   +1 more source

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensivity in a patient with xeroderma pigmentosum [PDF]

, 2010
Background: Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising radiation, immunodeficiency and increased cancer incidence.
Abbaszadeh, Fatemah, Arlett, Colin F., Bourton, E.C, Clingen, Peter H., Green, M H, Makarov, E.M., Newbold, R.F, Parris, C.N., Plowman, P.N, Themis, M.   +9 more
core   +1 more source

An efficient method for DNA extraction from Cladosporioid fungi [PDF]

, 2010
We developed an efficient method for DNA extraction from Cladosporioid fungi, which are important fungal plant pathogens. The cell wall of Cladosporioid fungi is often melanized, which makes it difficult to extract DNA from their cells.
Abd-Elsalam, K.A., Bahkali, A.H., Moslem, M.A., Wit, P.J.G.M., de   +3 more
core   +2 more sources

DNA demethylation by DNA repair [PDF]

Trends in Genetics, 2009
Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process.
Gehring, Mary, Reik, Wolf, Henikoff, Steven   +2 more
openaire   +4 more sources