Results 51 to 60 of about 6,548,876 (337)
Identification of novel citramalate biosynthesis pathways in Aspergillus niger
Fungal Biology and Biotechnology, 2019 Background The filamentous fungus Aspergillus niger is frequently used for industrial production of fermentative products such as enzymes, proteins and biochemicals. Notable examples of industrially produced A.
Abeer H. Hossain +2 more
doaj +1 more source
Capacity of DNA Data Embedding Under Substitution Mutations [PDF]
, 2011 A number of methods have been proposed over the last decade for encoding information using deoxyribonucleic acid (DNA), giving rise to the emerging area of DNA data embedding.
Balado, Félix
core +3 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Itaconic acid degradation in Aspergillus niger: the role of unexpected bioconversion pathways
Fungal Biology and Biotechnology, 2019 Background Itaconic acid (IA), a C5-dicarboxylic acid, has previously been identified as one of the top twelve biochemicals that can be produced by biotechnological means.
Abeer H. Hossain +2 more
doaj +1 more source
Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]
, 2016 DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C +4 more
core +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination [PDF]
Proceedings of the National Academy of Sciences, 2001 Two important and timely questions with respect to DNA replication, DNA recombination, and DNA repair are: ( i ) what controls which DNA polymerase gains access to a particular primer-terminus, and ( ii ) what determines whether a DNA polymerase hands off its DNA substrate to either a ...
Graham C. Walker, Mark D. Sutton
openaire +3 more sources
Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs
Communications MedicineBackground Proteolysis-targeting chimeras (PROTACs) are being developed for therapeutic use. However, they have poor pharmacokinetic profiles and their tissue distribution kinetics are not known. Methods A typical von Hippel-Lindau tumor suppressor (VHL)—
Donglu Zhang +16 more
doaj +1 more source
Accurate genome-wide phasing from IBD data
BMC Bioinformatics, 2022 As genotype databases increase in size, so too do the number of detectable segments of identity by descent (IBD): segments of the genome where two individuals share an identical copy of one of their two parental haplotypes, due to shared ancestry.
Keith Noto, Luong Ruiz
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source