Results 51 to 60 of about 8,837,195 (335)

Itaconic acid degradation in Aspergillus niger: the role of unexpected bioconversion pathways

Fungal Biology and Biotechnology, 2019
Background Itaconic acid (IA), a C5-dicarboxylic acid, has previously been identified as one of the top twelve biochemicals that can be produced by biotechnological means.
Abeer H. Hossain, Alexander Ter Beek, Peter J. Punt   +2 more
doaj   +1 more source

Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]

, 2013
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M, Heyer, Wolf-Dietrich, Hurwitz, Jerard, Sneeden, Jessica L, Tappin, Inger   +4 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs

Communications Medicine
Background Proteolysis-targeting chimeras (PROTACs) are being developed for therapeutic use. However, they have poor pharmacokinetic profiles and their tissue distribution kinetics are not known. Methods A typical von Hippel-Lindau tumor suppressor (VHL)—
Donglu Zhang, Bin Ma, Peter S. Dragovich, Li Ma, Shu Chen, Eugene C. Chen, Xiaofen Ye, Joyce Liu, Jennifer Pizzano, Elizabeth Bortolon, Emily Chan, Xing Zhang, Yi-Chen Chen, Elizabeth S. Levy, Robert L. Yauch, S. Cyrus Khojasteh, Cornelis E. C. A. Hop   +16 more
doaj   +1 more source

Accurate genome-wide phasing from IBD data

BMC Bioinformatics, 2022
As genotype databases increase in size, so too do the number of detectable segments of identity by descent (IBD): segments of the genome where two individuals share an identical copy of one of their two parental haplotypes, due to shared ancestry.
Keith Noto, Luong Ruiz
doaj   +1 more source

Force Induced DNA Melting

, 2008
When pulled along the axis, double-strand DNA undergoes a large conformational change and elongates roughly twice its initial contour length at a pulling force about 70 pN.
Maiti, Prabal K, Santosh, Mogurampelly
core   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
A Ganguly, A Hellman, A Helmrich, AA Burrow, AJ Swerdlow, AT Jonstrup, AY Chen, BH Long, C Pondarré, CH Cheng, Christine E. Lehman, CM Caudill, D Mishmar, D Vane, DJ Mulvihill, E Grabczyk, E Zlotorynski, F de Vathaire, F Pelliccia, FH Drake, FM Bar, G Abdurashidova, G Capranico, GR Bignell, GR Sutherland, H Zhang, HY Wu, I Bongarzone, J Sambrook, JC Wang, JM Allan, JM Fortune, K Reddy, K Takeuchi, KR Hande, KW Gow, L Enewold, L Postow, Laura W. Dillon, LB Travis, Le Beau, Levi C. T. Pierce, LF Liu, LW Dillon, LW Dillon, M Drolet, M Gandhi, M Zuker, MB Smith, MD Been, MD Been, MF Arlt, MN Nikiforova, MS Kim, NR Lemoine, O Handt, P Boffetta, PA Smanik, R Garcia-Carbonero, R Venkitaraman, RT Hay, S Anderson, S Corbin, S Klugbauer, S McAvoy, S Tuduri, S Wada, SG Durkin, SG Durkin, SJ Froelich-Ammon, SM Jhiang, SM Vos, SN Shah, T Kohno, T Kondo, T Syrovets, TW Glover, TW Glover, Valentin V Rybenkov, X Li, Y Lin, Y Lin, YE Nikiforov, YE Nikiforov, YE Nikiforov, Yuh-Hwa Wang, Yuri E. Nikiforov   +86 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]

, 2016
DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C, Lei, Xianbin, Marko, John F, McLean, Meghan M, Xiao, Botao   +4 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source