Results 131 to 140 of about 90,456 (335)

DNA-based identification of aquatic invertebrates useful in the South African context?

South African Journal of Science, 2016
The concept of using specific regions of DNA to identify organisms – processes such as DNA barcoding – is not new to South African biologists. The African Centre for DNA Barcoding reports that 12 548 plant species and 1493 animal species had been ...
Hermoine J. Venter, Cornelius C. Bezuidenhout   +1 more
doaj   +1 more source

MISSEL: a method to identify a large number of small species-specific genomic subsequences and its application to viruses classification [PDF]

, 2016
Continuous improvements in next generation sequencing technologies led to ever-increasing collections of genomic sequences, which have not been easily characterized by biologists, and whose analysis requires huge computational effort.
Babakir Mina, Muhammed, Bertolazzi, Paola, Cella, Eleonora, Ciccozzi, Massimo, Ciotti, Marco, Felici, Giovanni, Fiscon, Giulia, Giovanetti, Marta, Lo Presti, Alessandra, Pierangeli, Alessandra, Weitschek, Emanuel   +10 more
core   +2 more sources

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

Advanced Science, EarlyView.
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou, Yuqing Lv, Lin Li, Shukui Zhang, Jiaqi Liang, Chengchao Wu, Enyu Huang, Jianwei Jiao, Jingjing Zhang   +8 more
wiley   +1 more source

Potential efficacy of mitochondrial genes for animal DNA barcoding: a case study using eutherian mammals

BMC Genomics, 2011
Background A well-informed choice of genetic locus is central to the efficacy of DNA barcoding. Current DNA barcoding in animals involves the use of the 5' half of the mitochondrial cytochrome oxidase 1 gene (CO1) to diagnose and delimit species. However,
Shi Weifeng, Zhang Yanzhou, Xu Weijun, Ho Simon YW, Zhang Aibing, Luo Arong, Cameron Stephen L, Zhu Chaodong   +7 more
doaj   +1 more source

Ten species in one: DNA barcoding reveals cryptic species in the neotropical skipper butterflyAstraptes fulgerator [PDF]

, 2004
Paul D. N. Hebert, Erin H. Penton, John M. Burns, Daniel H. Janzen, Winnie Hallwachs   +4 more
openalex   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

DNA Barcoding in Meat Authentication: Principles, Applications, and Future Perspectives

Foods
DNA barcoding technology, as a species identification method based on specific DNA sequence variations, has been widely applied in meat product authentication in recent years.
Jiangyao Hu, Hewen Wei, Yanjie Jiang, Qingyu Xue, Feijuan Wang   +4 more
doaj   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

Deciphering amphibian diversity through DNA barcoding: chances and challenges [PDF]

, 2005
Miguel Vences, Meike Thomas, Ronald M. Bonett, David R. Vieites   +3 more
openalex   +1 more source