Results 91 to 100 of about 333,155 (283)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Antibody-controlled actuation of DNA-based molecular circuits

Nature Communications, 2017
Existing DNA based circuits, designed to perform logic operations and signal processing, are generally responsive to DNA or RNA inputs. Here, the authors show that antibodies can actuate DNA logic gates, opening the way to applications of DNA computing ...
Wouter Engelen, Lenny H. H. Meijer, Bram Somers, Tom F. A. de Greef, Maarten Merkx   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Tops and Writhing DNA

, 2010
The torsional elasticity of semiflexible polymers like DNA is of biological significance. A mathematical treatment of this problem was begun by Fuller using the relation between link, twist and writhe, but progress has been hindered by the non-local ...
A. Ghosh, A.E.H. Love, A.V. Vologodskii, B. Fain, C. Bouchiat, D. Swigon, F.B. Fuller, F.B. Fuller, G. Călugăreanu, G. Kirchoff, H. Goldstein, J. Cantarella, J. Marko, J. Moroz, J. Samuel, J. Samuel, J. White, J.D. Moroz, J.F. Marko, Joseph Samuel, M.A. Berger, M.V. Berry, N. Chouaieb, S. Forth, S. Neukirch, S. Sinha, Supurna Sinha, T.R. Strick, V. Rossetto, V. Rossetto   +29 more
core   +1 more source

Solution of a problem in DNA computing

Theoretical Computer Science, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Eric Anderson, Marek Chrobak, John Noga, Jirí Sgall, Gerhard J. Woeginger   +4 more
openaire   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Sticker systems over monoids [PDF]

, 2012
Molecular computing has gained many interests among researchers since Head introduced the first theoretical model for DNA based computation using the splicing operation in 1987.
Fong, Wan Heng, Hamzah, N. Z. A., Mohd. Sebry, N. A., Sarmin, NorHaniza, Turaev, S.   +4 more
core  

Recovering the state sequence of hidden Markov models using mean-field approximations

, 2009
Inferring the sequence of states from observations is one of the most fundamental problems in Hidden Markov Models. In statistical physics language, this problem is equivalent to computing the marginals of a one-dimensional model with a random external ...
Antoine Sinton, Cappé O, Elahi E, Eltoukhy H, Eltoukhy H El Gamal A, Ewing B, MacKay D J, Mézard M, Nyrén P, Wang Y Zhou L Feng J Wang J Liu Z-Q   +9 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A spatially localized DNA linear classifier for cancer diagnosis

Nature Communications
Molecular computing is an emerging paradigm that plays an essential role in data storage, bio-computation, and clinical diagnosis with the future trends of more efficient computing scheme, higher modularity with scaled-up circuity and stronger tolerance ...
Linlin Yang, Qian Tang, Mingzhi Zhang, Yuan Tian, Xiaoxing Chen, Rui Xu, Qian Ma, Pei Guo, Chao Zhang, Da Han   +9 more
doaj   +1 more source