Results 91 to 100 of about 127,811 (292)
Computing Without Computing: DNA Version [PDF]
, 2019 The traditional DNA computing schemes are based on using or simulating DNA-related activity. This is similar to how quantum computers use quantum activities to perform computations.
Urenda, Julio C., Kreinovich, Vladik
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Neuromorphic Computing and EngineeringDNA and other biopolymers are being investigated as new computing substrates and alternative to silicon-based digital computers. However, the established top–down design of biomolecular interaction networks remains challenging and does not fully exploit ...
Tanmay Pandey +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Antibody-controlled actuation of DNA-based molecular circuits
Nature Communications, 2017 Existing DNA based circuits, designed to perform logic operations and signal processing, are generally responsive to DNA or RNA inputs. Here, the authors show that antibodies can actuate DNA logic gates, opening the way to applications of DNA computing ...
Wouter Engelen +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Computational analysis of promoters and DNA-protein interactions [PDF]
, 2009 The investigation of promoter activity and DNA-protein interactions is very important for understanding many crucial cellular processes, including transcription, recombination and replication.
Tomovic, Andrija
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
In silico estimation of annealing specificity of query searches in DNA databases [PDF]
, 2005 We consider DNA implementations of databases for digital signals with retrieval and mining capabilities. Digital signals are encoded in DNA sequences and retrieved through annealing between query DNA primers and data carrying DNA target sequences.
Tsaftaris, Sotirios A. +2 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2004 : DNA computing is an alternative method of performing computations. It is based on the observation that in general it is possible to design a series of biochemical experiments involving DNA molecules which is equivalent to processing information encoded
Piotr Formanowicz
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