Results 111 to 120 of about 3,749,303 (292)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Accelerating DNA-Based Computing on a Supramolecular Polymer [PDF]

, 2018
Dynamic DNA-based circuits represent versatile systems to perform complex computing operations at the molecular level. However, the majority of DNA circuits relies on freely diffusing reactants, which slows down their rate of operation substantially ...
Sjors P. W. Wijnands (1736209), Wouter Engelen (1365936), Wijnands, Sjors P.W., Engelen, Wouter, Merkx, Maarten, Maarten Merkx (491673)   +5 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Enzyme-driven triplex structure-based DNA logic circuits

Journal of Nanobiotechnology
DNA logic circuits have emerged as crucial media for biological computing due to their molecular-level parallelism and high biocompatibility. In the two mainstream systems currently prevalent, the strand-displacement system generally suffers from issues ...
Xiao Liu, Jing Zhang, Xuehao Zhang, Zhuo Chen, Shize Zhang, Xinyu Wang, Jiaying Liu, Zhiheng Wang, Liyi Xie, Zhihao Ming, Longjie Li, Kaixiong Tao, Xianjin Xiao, Xiaoyu Zhou, Yu Xie   +14 more
doaj   +1 more source

An automated DNA computing platform for rapid etiological diagnostics. [PDF]

Sci Adv, 2022
Ma Q, Zhang M, Zhang C, Teng X, Yang L, Tian Y, Wang J, Han D, Tan W.   +8 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

A DNA computing methodology

, 2004
A computação com DNA é um campo da Bioinformática que, através da manipulação de seqüências de DNA, busca a solução de problemas. Em 1994, o matemático Leonard Adleman, utilizando operações biológicas e manipulação de seqüências de DNA, solucionou uma ...
Isaia Filho, Eduardo
core   +1 more source

A nanopore interface for higher bandwidth DNA computing. [PDF]

Nat Commun, 2022
Zhang K, Zhang K, Chen YJ, Wilde D, Doroschak K, Strauss K, Ceze L, Seelig G, Nivala J.   +8 more
europepmc   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Massively Parallel DNA Computing Based on Domino DNA Strand Displacement Logic Gates. [PDF]

ACS Synth Biol, 2022
Chen X, Liu X, Wang F, Li S, Chen C, Qiang X, Shi X.   +6 more
europepmc   +1 more source