Results 111 to 120 of about 127,811 (292)

In memoriam of Yurii Rogozhin [PDF]

open access: yesComputer Science Journal of Moldova, 2019
November 13, 2019 would be the 70th birthday of Prof. Yurii Rogozhin. Dr. hab.~Yurii Rogozhin (November 13, 1949 $\dagger$ March 10, 2014) was a worldwide known computer scientist with diverse interests, ranged from finding small universal Turing ...
The staff of the Vladimir Andrunachievici Institute of Mathematics and Computer Science
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Basic architecture and applications of DNA computing [PDF]

open access: yes, 2016
DNA computing is a new computing paradigm utilizing actual DNA oligonucleotides to do computation by employing biomolecular tools to get the reaction and outputs extraction. In this paper, we introduce basic architecture of DNA computing.
Anis Amalina
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Minimum Finding with DNA Computing ∗ [PDF]

open access: yes, 2008
Recently, DNA computing is one of powerful tools that can be designed for solving NP-complete problems. The powers of DNA computing are that it has great ability of massive data storage and it can process those data in parallel.
Chang-biau Yang   +3 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Advance the DNA computing [PDF]

open access: yes, 2004
It has been previously shown that DNA computing can solve those problems currently intractable on even the fastest electronic computers. The algorithm design for DNA computing, however, is not straightforward.
Qiu, Zhiquan Frank
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Accelerating DNA computing via freeze-thaw cycling. [PDF]

open access: yesSci Adv, 2023
Zhu Y   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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