Results 101 to 110 of about 333,155 (283)
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Quantum-assisted biomolecular modelling
, 2010 Our understanding of the physics of biological molecules, such as proteins and DNA, is limited because the approximations we usually apply to model inert materials are not in general applicable to soft, chemically inhomogeneous systems.
Harris, Sarah, Kendon, Vivien M.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Advanced SciencePartial differential equations, essential for modeling dynamic systems, persistently confront computational complexity bottlenecks in high‐dimensional problems, yet DNA‐based parallel computing architectures, leveraging their discrete mathematics merits,
Yijun Xiao +5 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Encoding Genetic and Structural Information in DNA Using Electric Field Gradients and Nuclear Spins
Intelligent ComputingNuclear electric resonance (NER) offers a method of controlling nuclear spins using electric field gradients (EFGs), which is a critical concept in quantum computing.
Yu Zheng, Quansheng Ren
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
In memoriam of Yurii Rogozhin [PDF]
Computer Science Journal of Moldova, 2019 November 13, 2019 would be the 70th birthday of Prof. Yurii Rogozhin. Dr. hab.~Yurii Rogozhin (November 13, 1949 $\dagger$ March 10, 2014) was a worldwide known computer scientist with diverse interests, ranged from finding small universal Turing ...
The staff of the Vladimir Andrunachievici Institute of Mathematics and Computer Science
doaj
General Purpose Parallel Computation on a DNA Substrate [PDF]
, 1996 In this paper I describe and extend a new DNA computing paradigm introduced in Blumberg for building massively parallel machines in the DNA-computing models described by Adelman, Cai et. al., and Liu et. al.
Blumberg, Andrew Justin
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