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An unnatural base pair for the detection of epigenetic cytosine modifications in DNA. [PDF]
Nat ChemSchmidl D +3 more
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Kinetic analysis of catalytic activity of G-quadruplex/hemin DNAzyme with flanking adenine nucleotides. [PDF]
Sci RepUdomprasert A +2 more
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Mammalian DNA (cytosine-5) methyltransferases and their expression.
Clinical Immunology, 2003Two classes of functional DNA (cytosine-5) methyltransferases have been discovered in mammals to date. One class methylates the unmodified DNA and is designated as the de novo enzyme, whereas the other maintains the methylation status of the daughter strand during DNA replication and thus is referred to as a maintenance DNA methyltransferase.
S. Pradhan, P. Esteve
semanticscholar +3 more sources
Cytosine-5-methyltransferases add aldehydes to DNA.
Nature Chemical Biology, 2009Targeted methylation of cytosine residues by S-adenosylmethionine-dependent DNA methyltransferases modulates gene expression in vertebrates. Here we show that cytosine-5-methyltransferases catalyze reversible covalent addition of exogenous aliphatic aldehydes to their target residues in DNA, thus yielding corresponding 5-hydroxyalkylcytosines.
Z. Liutkevičiūtė +4 more
semanticscholar +4 more sources
Biochimie, 2017
Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways.
G. Rondelet, J. Wouters
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Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways.
G. Rondelet, J. Wouters
semanticscholar +3 more sources
Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila
Nature Genetics, 1999CpG methylation is essential for mouse development as well as gene regulation and genome stability. Many features of mammalian DNA methylation are consistent with the action of a de novo methyltransferase that establishes methylation patterns during early development and the post-replicative maintenance of these patterns by a maintenance ...
F. Lyko +6 more
semanticscholar +3 more sources
Purification of human DNA (cytosine‐5‐)‐methyltransferase
Journal of Cellular Biochemistry, 1985AbstractWe have developed a facile procedure for the purification of DNA methyltransferase activity from human placenta. The procedure avoids the isolation of nuclei and the dialysis and chromatography of large volumes. A purification of 38,000‐fold from the whole cell extract has been achieved.
K E, Zucker, A D, Riggs, S S, Smith
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Recognition of foldback DNA by the human DNA (cytosine-5-) methyltransferase
Biochemistry, 1992In order to specify the recognition requirements of the human DNA (cytosine-5-)-methyltransferase, two isomeric 48mers were synthesized so as to link a long block of DNA with a shorter complementary block of DNA through a tether consisting of five thymidine residues.
S S, Smith, R G, Lingeman, B E, Kaplan
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Recognition of unusual DNA structures by human DNA(cytosine-5)methyltransferase
Journal of Molecular Biology, 1991The symmetry of the responses of the human DNA (cytosine-5)methyltransferase to alternative placements of 5-methylcytosine in model oligodeoxynucleotide duplexes containing unusual structures has been examined. The results of these experiments more clearly define the DNA recognition specificity of the enzyme. A simple three-nucleotide recognition motif
S S, Smith +4 more
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