Results 81 to 90 of about 108,714 (328)

Identification of a Proliferation Gene Cluster Associated with HPV E6/E7 Expression Level and Viral DNA Load in Invasive Cervical Carcinoma

, 2005
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière, Christophe Rosty, Dafna Tsafrir, Eytan Domany, F Ferlay, François Radvanyi, Ilan Tsafrir, Jean Paul Thiery, Jérôme Couturier, Martine Peter, Michal Sheffer, Nicolas Stransky, Patricia de Crémoux, Rémy Salmon, Thierry Dorval, Xavier Sastre-Garau   +15 more
core   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field

iScience
Summary: 4-Methylcytosine (4mC) and 6-methyladenine (6mA) are the most prevalent types of DNA modifications in prokaryotes. However, whether there is crosstalk between 4mC and 6mA remain unknown.
Zhenhua Shi, Yingrong Zhang, Wanqiu Chen, Zhen Yu   +3 more
doaj   +1 more source

Recent Progress in Electrochemical Biosensors for Detection of DNA Methylation and Methyltransferase Activity

International Journal of Electrochemical Science, 2019
DNA methylation is one of the most studied epigenetic modifications of DNA. The methylation at C-5 position of cytosine has been proved to be related to a wide range of biological phenomena. Therefore, it is very important to develop a simple, sensitive,
Ning Xia, Yuanqiang Hao
doaj   +1 more source

Candidate genes that may be responsible for the unusual resistances exhibited by Bacillus pumilus SAFR-032 spores [PDF]

, 2013
The spores of several Bacillus species, including Bacillus pumilus SAFR-032 and B. safensis FO-36b, which were isolated from the spacecraft assembly facility at NASA's Jet Propulsion Laboratory, are unusually resistant to UV radiation and hydrogen ...
Allen, Shamail, Diouf, Fatma, Fox, George E, Kwende, Sharon, Rastogi, Rajat, Tirumalai, Madhan R, Venkateswaran, Kasthuri J, Weinstock, George M, Williams, Elisha O\u27Bryant, Zamani, Nader   +9 more
core   +4 more sources

Molecularly Engineered Highly Stable Memristors with Ultra‐Low Operational Voltage: Integrating Synthetic DNA with Quasi‐2D Perovskites

Advanced Functional Materials, EarlyView.
Molecularly engineered memristors integrating Ag nanoparticle–embedded synthetic DNA with quasi‐2D halide perovskites enable ultra‐low‐operational voltage, forming‐free resistive switching, and record‐low power density. This synergistic integration of customized DNA and 2D OHP in bio‐hybrid architecture enhances charge transport, reduces variability ...
Kavya S. Keremane, Abhinav Gorthy, Luyao Zheng, Chiranth C Ravi, Haodong Wu, Jiamao Zheng, Neela H. Yennawar, Shashank Priya, Rashmi Jha, Bed Poudel   +9 more
wiley   +1 more source

Scalable screening of ternary-code DNA methylation dynamics associated with human traits

Cell Genomics
Summary: Epigenome-wide association studies (EWASs) are transforming our understanding of the interplay between epigenetics and complex human traits.
David C. Goldberg, Cameron Cloud, Sol Moe Lee, Bret Barnes, Steven Gruber, Elliot Kim, Anita Pottekat, Maximillian S. Westphal, Luana McAuliffe, Elisa Majounie, Manesh Kalayil Manian, Qingdi Zhu, Christine Tran, Mark Hansen, Jelena Stojakovic, Jared B. Parker, Rahul M. Kohli, Rishi Porecha, Nicole Renke, Wanding Zhou   +19 more
doaj   +1 more source

The SCO1731 methyltransferase modulates actinorhodin production and morphological differentiation of Streptomyces coelicolor A3(2)

Scientific Reports, 2018
Streptomyces coelicolor is a Gram-positive microorganism often used as a model of physiological and morphological differentiation in streptomycetes, prolific producers of secondary metabolites with important biological activities.
Annalisa Pisciotta, Angel Manteca, Rosa Alduina   +2 more
doaj   +1 more source

Epigenetic machinery is functionally conserved in cephalopods

BMC Biology, 2022
Background Epigenetic regulatory mechanisms are divergent across the animal kingdom, yet these mechanisms are not well studied in non-model organisms.
Filippo Macchi, Eric Edsinger, Kirsten C. Sadler   +2 more
doaj   +1 more source

Epigenetic Regulation of Genomic Stability by Vitamin C

Frontiers in Genetics, 2021
DNA methylation plays an important role in the maintenance of genomic stability. Ten-eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG -dependent dioxygenases that regulate DNA methylation levels by oxidizing 5-methylcystosine ...
John P. Brabson, John P. Brabson, Tiffany Leesang, Tiffany Leesang, Sofia Mohammad, Luisa Cimmino, Luisa Cimmino   +6 more
doaj   +1 more source