Results 71 to 80 of about 95,440 (308)

Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field

iScience
Summary: 4-Methylcytosine (4mC) and 6-methyladenine (6mA) are the most prevalent types of DNA modifications in prokaryotes. However, whether there is crosstalk between 4mC and 6mA remain unknown.
Zhenhua Shi, Yingrong Zhang, Wanqiu Chen, Zhen Yu   +3 more
doaj   +1 more source

Recent Progress in Electrochemical Biosensors for Detection of DNA Methylation and Methyltransferase Activity

International Journal of Electrochemical Science, 2019
DNA methylation is one of the most studied epigenetic modifications of DNA. The methylation at C-5 position of cytosine has been proved to be related to a wide range of biological phenomena. Therefore, it is very important to develop a simple, sensitive,
Ning Xia, Yuanqiang Hao
doaj   +1 more source

Plant cytosine-5 DNA methyltransferases: Structure, function, and molecular evolution

Genomics, 2007
A detailed analysis of the structure and function, along with evolutionary aspects, of the main plant cytosine-5 DNA methyltransferases (C5-MTases) is presented. The evolutionary relationships between the already known and four candidate plant C5-MTases identified in this work were investigated using the distance, maximum-parsimony, and maximum ...
Kossida, Sophia, Pavlopoulou, ATHANASIA
openaire   +3 more sources

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Determination of Methylation Site of DNA-Methyltransferase NlaX by a Hybrid Method

BioTechniques, 2002
Using a new method based on a combination of bisulfite reaction, the repair enzyme uracil-DNA glycosylase, and synthetic oligodeoxyribonucleotides, the methylation site of DNA-methyltransferase NlaX (M·NlaX) from Neisseria lactamica was established to be
E.A. Kubareva, J. Walter, A.S. Karyagina, O.V. Vorob'eva, P.C.K. Lau, T. Trautner   +5 more
doaj   +1 more source

Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues [PDF]

Proceedings of the National Academy of Sciences, 1999
Thus far, only one major form of vertebrate DNA (cytosine-5) methyltransferase (CpG MTase, EC 2.1.1.37 ) has been identified, cloned, and extensively studied. This enzyme, dnmt1, has been hypothesized to be responsible for most of the maintenance as well as the de novo methylation activities ...
D W, Hsu, M J, Lin, T L, Lee, S C, Wen, X, Chen, C K, Shen   +5 more
openaire   +2 more sources

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Scalable screening of ternary-code DNA methylation dynamics associated with human traits

Cell Genomics
Summary: Epigenome-wide association studies (EWASs) are transforming our understanding of the interplay between epigenetics and complex human traits.
David C. Goldberg, Cameron Cloud, Sol Moe Lee, Bret Barnes, Steven Gruber, Elliot Kim, Anita Pottekat, Maximillian S. Westphal, Luana McAuliffe, Elisa Majounie, Manesh Kalayil Manian, Qingdi Zhu, Christine Tran, Mark Hansen, Jelena Stojakovic, Jared B. Parker, Rahul M. Kohli, Rishi Porecha, Nicole Renke, Wanding Zhou   +19 more
doaj   +1 more source

The SCO1731 methyltransferase modulates actinorhodin production and morphological differentiation of Streptomyces coelicolor A3(2)

Scientific Reports, 2018
Streptomyces coelicolor is a Gram-positive microorganism often used as a model of physiological and morphological differentiation in streptomycetes, prolific producers of secondary metabolites with important biological activities.
Annalisa Pisciotta, Angel Manteca, Rosa Alduina   +2 more
doaj   +1 more source

Epigenetic machinery is functionally conserved in cephalopods

BMC Biology, 2022
Background Epigenetic regulatory mechanisms are divergent across the animal kingdom, yet these mechanisms are not well studied in non-model organisms.
Filippo Macchi, Eric Edsinger, Kirsten C. Sadler   +2 more
doaj   +1 more source