Results 51 to 60 of about 1,030,824 (346)

FZD5 contributes to TNBC proliferation, DNA damage repair and stemness

Cell Death and Disease, 2020
Chemotherapy currently remains the standard treatment for triple-negative breast cancer (TNBC). However, TNBC frequently develop chemoresistance, which is responsible for cancer recurrence and distal metastasis.
Yu Sun, Zhuo Wang, Lei Na, Dan Dong, Wei Wang, Chenghai Zhao   +5 more
semanticscholar   +1 more source

DNA Damage, DNA Repair, Aging, and Neurodegeneration [PDF]

Cold Spring Harbor Perspectives in Medicine, 2015
Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids. The sequence of the human genome represents our genetic blueprint, and accumulating evidence suggests that loss of genomic maintenance may causally contribute to aging.
Maynard, Scott, Fang, Evandro Fei, Scheibye-Knudsen, Morten, Croteau, Deborah L., Bohr, Vilhelm A.   +4 more
openaire   +3 more sources

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]

, 2018
The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda, Alvey, Andrea J. Liu, Broers, Burma, Buxboim, Buxboim, Capo-chichi, Chang, Charlotte R. Pfeifer, Coffinier, Cory M. Alvey, Cumming, Darzynkiewicz, Das, Dazhen Liu, de la Rosa, De Vos, Denais, Dennis E. Discher, Dingal, Docheva, Elosegui-Artola, Fong, Frigault, Grundy, Gudmundsdottir, Harada, Harding, Hatch, Hategan, Hernandez, Irena L. Ivanovska, Irianto, Ivanovska, Jerome Irianto, Jiazheng Ji, Kaspi, Kuangzheng Zhu, Lammerding, Larrieu, Levental, Lucas Smith, Nuciforo, Odde, Oh, Raab, Rachel R. Bennett, Roger A. Greenberg, Saez, Samudram, Sangkyun Cho, Schneider, Seluanov, Shin, Soubeyrand, Staszewski, Swift, Takaki, Tamiello, Tang, Turgay, Wang, Yuntao Xia, Álvarez-Quilón   +64 more
core   +2 more sources

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

Science Advances, 2019
SIRT7 plays a critical role in dissembling and deactivating ATM when DNA damage repair is completed. The activation of ataxia-telangiectasia mutated (ATM) upon DNA damage involves a cascade of reactions, including acetylation by TIP60 and ...
Ming Tang, Zhiming Li, Chaohua Zhang, Xiaopeng Lu, Bo Tu, Z. Cao, Yinglu Li, Yongcan Chen, Lu Jiang, Hui Wang, Lina Wang, Jiadong Wang, Baohua Liu, Xingzhi Xu, Haiying Wang, Wei-Guo Zhu   +15 more
semanticscholar   +1 more source

Loss of urokinase receptor sensitizes cells to DNA damage and delays DNA repair. [PDF]

PLoS ONE, 2014
DNA damage induced by numerous exogenous or endogenous factors may have irreversible consequences on the cell leading to cell cycle arrest, senescence and cell death.
Pavan B Narayanaswamy, Mahshid Hodjat, Hermann Haller, Inna Dumler, Yulia Kiyan   +4 more
doaj   +1 more source

Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA

Cells, 2022
AsiDNA is a DNA repair inhibitor mimicking DNA double-strand breaks (DSB) that was designed to disorganize DSB repair pathways to sensitize tumors to DNA damaging therapies such as radiotherapy and chemotherapy.
Nathalie Berthault, Ptissam Bergam, Floriane Pereira, Pierre-Marie Girard, Marie Dutreix   +4 more
doaj   +1 more source

PALB2 self-interaction controls homologous recombination. [PDF]

, 2012
PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination.
Buisson, Rémi, Masson, Jean-Yves
core   +1 more source

Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair.

Cell Reports, 2019
Radiation resistance is a critical problem in radiotherapy for cancer. Radiation kills tumor cells mainly through causing DNA damage. Thus, efficiency of DNA damage repair is one of the most important factors that limits radiotherapy efficacy.
Shujun Fu, Zhi Li, Lanbo Xiao, Wenfeng Hu, Lu Zhang, B. Xie, Qin Zhou, Junjun He, Yanfang Qiu, Mingzhi Wen, Yanni Peng, Jie Gao, Rong Tan, Yuezhen Deng, Liang Weng, Lunquan Sun   +15 more
semanticscholar   +1 more source

From single-molecule to genome-wide mapping of DNA lesions: repair-assisted damage detection sequencing

Biophysical Reports, 2021
Mapping DNA damage and its repair has immense potential in understanding environmental exposures, their genotoxicity, and their impact on human health.
Noa Gilat, Dena Fridman, Hila Sharim, Sapir Margalit, Natalie R. Gassman, Yael Michaeli, Yuval Ebenstein   +6 more
doaj   +1 more source

DNA Repair by Reversal of DNA Damage [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms to defend against the deleterious effects of DNA damage. Among these diverse repair pathways, direct DNA-repair systems provide cells with simple yet efficient solutions to ...
Chengqi, Yi, Chuan, He
openaire   +3 more sources