Results 51 to 60 of about 976,559 (349)

DNA damage, repair and aging

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2003
Oxidative DNA damage has been shown to accumulate with age in the nuclear and mitochondrial genome and cause cancer. Among DNA lesions produced by reactive oxygen species, base lesions and single-strand breaks are most frequently produced and cause mutation and cell death.
Akira, Yasui, Shin-ichiro, Kanno, Masashi, Takao   +2 more
openaire   +3 more sources

Loss of urokinase receptor sensitizes cells to DNA damage and delays DNA repair. [PDF]

PLoS ONE, 2014
DNA damage induced by numerous exogenous or endogenous factors may have irreversible consequences on the cell leading to cell cycle arrest, senescence and cell death.
Pavan B Narayanaswamy, Mahshid Hodjat, Hermann Haller, Inna Dumler, Yulia Kiyan   +4 more
doaj   +1 more source

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

DNA Damage, DNA Repair, Aging, and Neurodegeneration [PDF]

Cold Spring Harbor Perspectives in Medicine, 2015
Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids. The sequence of the human genome represents our genetic blueprint, and accumulating evidence suggests that loss of genomic maintenance may causally contribute to aging.
Maynard, Scott, Fang, Evandro Fei, Scheibye-Knudsen, Morten, Croteau, Deborah L., Bohr, Vilhelm A.   +4 more
openaire   +3 more sources

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

Science Advances, 2019
SIRT7 plays a critical role in dissembling and deactivating ATM when DNA damage repair is completed. The activation of ataxia-telangiectasia mutated (ATM) upon DNA damage involves a cascade of reactions, including acetylation by TIP60 and ...
Ming Tang, Zhiming Li, Chaohua Zhang, Xiaopeng Lu, Bo Tu, Z. Cao, Yinglu Li, Yongcan Chen, Lu Jiang, Hui Wang, Lina Wang, Jiadong Wang, Baohua Liu, Xingzhi Xu, Haiying Wang, Wei-Guo Zhu   +15 more
semanticscholar   +1 more source

The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer

Frontiers in Oncology, 2020
Despite advances in our understanding of the molecular biology of the disease and improved therapeutics, lung cancer remains the most common cause of cancer-related deaths worldwide. Therefore, an unmet need remains for improved treatments, especially in
J. Burgess, M. Rose, D. Boucher, J. Plowman, C. Molloy, M. Fisher, C. O'Leary, D. Richard, K. O'Byrne, E. Bolderson   +9 more
semanticscholar   +1 more source

Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA

Cells, 2022
AsiDNA is a DNA repair inhibitor mimicking DNA double-strand breaks (DSB) that was designed to disorganize DSB repair pathways to sensitize tumors to DNA damaging therapies such as radiotherapy and chemotherapy.
Nathalie Berthault, Ptissam Bergam, Floriane Pereira, Pierre-Marie Girard, Marie Dutreix   +4 more
doaj   +1 more source

PALB2 self-interaction controls homologous recombination. [PDF]

, 2012
PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination.
Buisson, Rémi, Masson, Jean-Yves
core   +1 more source

FZD5 contributes to TNBC proliferation, DNA damage repair and stemness

Cell Death and Disease, 2020
Chemotherapy currently remains the standard treatment for triple-negative breast cancer (TNBC). However, TNBC frequently develop chemoresistance, which is responsible for cancer recurrence and distal metastasis.
Yu Sun, Zhuo Wang, Lei Na, Dan Dong, Wei Wang, Chenghai Zhao   +5 more
semanticscholar   +1 more source

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]

, 2018
The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda, Alvey, Andrea J. Liu, Broers, Burma, Buxboim, Buxboim, Capo-chichi, Chang, Charlotte R. Pfeifer, Coffinier, Cory M. Alvey, Cumming, Darzynkiewicz, Das, Dazhen Liu, de la Rosa, De Vos, Denais, Dennis E. Discher, Dingal, Docheva, Elosegui-Artola, Fong, Frigault, Grundy, Gudmundsdottir, Harada, Harding, Hatch, Hategan, Hernandez, Irena L. Ivanovska, Irianto, Ivanovska, Jerome Irianto, Jiazheng Ji, Kaspi, Kuangzheng Zhu, Lammerding, Larrieu, Levental, Lucas Smith, Nuciforo, Odde, Oh, Raab, Rachel R. Bennett, Roger A. Greenberg, Saez, Samudram, Sangkyun Cho, Schneider, Seluanov, Shin, Soubeyrand, Staszewski, Swift, Takaki, Tamiello, Tang, Turgay, Wang, Yuntao Xia, Álvarez-Quilón   +64 more
core   +2 more sources