Results 271 to 280 of about 752,369 (314)

Inhibition of NAMPT targets DNA damage response to sensitize alkylating chemotherapy in TP53 mutant mantle cell lymphoma. [PDF]

Blood Adv
Li N, Liu Y, Zhang L, Guo S, Wu Z, Xu Y, Yang M, Kong J, Che Y, Shao K, Yang H.   +10 more
europepmc   +1 more source

[Corrigendum] Inhibition of DNA‑PK activity sensitizes A549 cells to X‑ray irradiation by inducing the ATM‑dependent DNA damage response. [PDF]

Mol Med Rep
Yang L, Yang X, Tang Y, Zhang D, Zhu L, Wang S, Wang B, Ma T.   +7 more
europepmc   +1 more source

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DNA Damage Response in Nucleoli

Molecular Biology, 2021
Nucleoli, the largest subnuclear compartments, are formed around arrays of ribosomal gene repeats transcribed by RNA polymerase I. The primary function of nucleoli is ribosome biogenesis. Specific DNA damage response mechanisms exist to maintain the genomic stability of ribosomal repeats.
A K, Velichko, S V, Razin, O L, Kantidze
openaire   +2 more sources

DNA damage response and transcription

DNA Repair, 2011
A network of DNA damage surveillance systems is triggered by sensing of DNA lesions and the initiation of a signal transduction cascade that activates genome-protection pathways including nucleotide excision repair (NER). NER operates through coordinated assembly of repair factors into pre- and post-incision complexes.
Lagerwerf, S., Vrouwe, M.G., Overmeer, R.M., Fousteri, M.I., Mullenders, L.H.F.   +4 more
openaire   +3 more sources

Regulators in the DNA damage response

Archives of Biochemistry and Biophysics, 2016
Maintenance of genome integrity is essential for the proper function of all cells and organisms. In response to both endogenous and exogenous DNA damaging agents, mammalian cells have evolved a delicate system to sense DNA damage, stop cell cycle progression, modulate cell metabolism, repair damaged DNA, and induce programmed cell death if the damage ...
Yunhua, Liu, Yujing, Li, Xiongbin, Lu
openaire   +2 more sources

The cellular responses to DNA damage

Trends in Cell Biology, 1995
The ability to survive spontaneous and induced DNA damage, and to minimize the number of heritable mutations that this causes, is essential to the maintenance of genome integrity for all organisms. Early studies on model eukaryotes focused on genes acting in defined DNA repair pathways. More recent work with the budding and fission yeasts and mammalian
A M, Carr, M F, Hoekstra
openaire   +2 more sources

Cellular Response to DNA Damage

Annals of the New York Academy of Sciences, 2006
Abstract: Eukaryotic cells, from yeast to man, possess evolutionarily conserved mechanisms to accurately and efficiently repair the overwhelming majority of DNA damage, thereby ensuring genomic integrity. Important repair pathways include base excision repair, nucleotide excision repair, mismatch repair, non‐homologous end‐joining, and homologous ...
Johnny, Kao, Barry S, Rosenstein, Sheila, Peters, Michael T, Milano, Stephen J, Kron   +4 more
openaire   +2 more sources

Transcriptional responses to DNA damage

Current Opinion in Microbiology, 2001
In Escherichia coli, DNA repair and protective responses are regulated at the transcriptional level. Regulatory mechanisms have evolved that allow cells to respond to DNA damage by mounting the appropriate responses. The regulatory proteins controlling these responses are activated when they recognize the presence of a specific DNA damaging agent, the ...
M R, Volkert, P, Landini
openaire   +2 more sources