Results 261 to 270 of about 1,213,538 (303)
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Cellular Response to DNA Damage
Annals of the New York Academy of Sciences, 2006Abstract: Eukaryotic cells, from yeast to man, possess evolutionarily conserved mechanisms to accurately and efficiently repair the overwhelming majority of DNA damage, thereby ensuring genomic integrity. Important repair pathways include base excision repair, nucleotide excision repair, mismatch repair, non‐homologous end‐joining, and homologous ...
Johnny, Kao +4 more
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DNA damage response and transcription
DNA Repair, 2011A network of DNA damage surveillance systems is triggered by sensing of DNA lesions and the initiation of a signal transduction cascade that activates genome-protection pathways including nucleotide excision repair (NER). NER operates through coordinated assembly of repair factors into pre- and post-incision complexes.
Lagerwerf, S. +4 more
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DNA damage response and neuroprotection
Frontiers in Bioscience, 2008The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults. To cope with the consequences of DNA lesions which interfere with essential DNA-dependent processes including transcription and replication, cells are equipped with an efficient defense mechanism ...
Inna I, Kruman, Elena I, Schwartz
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Mammalian DNA Damage Response Pathway
2006The DNA damage response pathway is critical for the maintenance of genomic stability. Many components of this pathway are tumour suppressors, such as p53, ATM, BRCA1, NBS1, Mre11 and Chk2, underlining the critical role of the DNA damage response pathway in tumour suppression.
Zhenkun, Lou, Junjie, Chen
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Transcriptional responses to DNA damage
Current Opinion in Microbiology, 2001In Escherichia coli, DNA repair and protective responses are regulated at the transcriptional level. Regulatory mechanisms have evolved that allow cells to respond to DNA damage by mounting the appropriate responses. The regulatory proteins controlling these responses are activated when they recognize the presence of a specific DNA damaging agent, the ...
M R, Volkert, P, Landini
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The DNA damage response during DNA replication
Current Opinion in Cell Biology, 2005Eukaryotic chromosome replication is mediated by multiple replicons and is coordinated with sister chromatid cohesion, DNA recombination, transcription and cell cycle progression. Replication forks stall or collapse at DNA lesions or problematic genomic regions, and these events have often been associated with recombination and chromosomal ...
M. Foiani, D. Branzei
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Neurology, 2018
An estimated 105 DNA lesions occur daily in the mammalian genome as a consequence of spontaneous decay, replication errors, and cell metabolism, including reactive oxygen species produced by the mitochondria. Oxidative stress is a major mechanism of DNA damage in the nervous system.
Elizabeth A, Coon, Eduardo E, Benarroch
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An estimated 105 DNA lesions occur daily in the mammalian genome as a consequence of spontaneous decay, replication errors, and cell metabolism, including reactive oxygen species produced by the mitochondria. Oxidative stress is a major mechanism of DNA damage in the nervous system.
Elizabeth A, Coon, Eduardo E, Benarroch
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DNA damage response pathway in radioadaptive response
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002Radioadaptive response is a biological defense mechanism in which low-dose ionizing irradiation elicits cellular resistance to the genotoxic effects of subsequent irradiation. However, its molecular mechanism remains largely unknown. We previously demonstrated that the dose recognition and adaptive response could be mediated by a feedback signaling ...
Masao S, Sasaki +6 more
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Cellular responses to DNA damage
Current Opinion in Cell Biology, 1998The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNA repair. In multicellular organisms, DNA damage can also activate programmed cell death.
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Aurora kinases and DNA damage response
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2020It is well established that Aurora kinases perform critical functions during mitosis. It has become increasingly clear that the Aurora kinases also perform a myriad of non-mitotic functions including DNA damage response. The available evidence indicates that inhibition Aurora kinase A (AURKA) may contribute to the G2 DNA damage checkpoint through AURKA'
Ma, Hoi Tang, Poon, Randy Y. C.
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