Results 281 to 290 of about 752,369 (314)

Chromatin and the DNA damage response

DNA Repair, 2005
The impact of chromatin structure upon the DNA damage response is becoming increasingly apparent. We can reasonably expect many more papers showing how chromatin and chromatin modifications impact upon aspects of the DNA damage response. Here, we present our perspective on some recent developments in this exciting area of cell biology. We aim that this
Lydall DA, Whitehall SK
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DNA damage response and neuroprotection

Frontiers in Bioscience, 2008
The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults. To cope with the consequences of DNA lesions which interfere with essential DNA-dependent processes including transcription and replication, cells are equipped with an efficient defense mechanism ...
Inna I, Kruman, Elena I, Schwartz
openaire   +2 more sources

Cellular responses to DNA damage

Current Opinion in Cell Biology, 1998
The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNA repair. In multicellular organisms, DNA damage can also activate programmed cell death.
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Accolades for the DNA Damage Response

New England Journal of Medicine, 2015
Given the importance to human health of the DNA damage response, it's not surprising that the Lasker Award for Basic Medical Research is being given to two scientists who have elucidated this response: Evelyn Witkin for work in bacteria and Stephen Elledge for work in eukaryotes.
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The p53 response to DNA damage

DNA Repair, 2004
The p53 tumour suppressor protein is a highly potent transcription factor which, under normal circumstances, is maintained at low levels through the action of MDM2, an E3 ubiquitin ligase which directs p53 ubiquitylation and degradation. Expression of the mdm2 gene is stimulated by p53 and this reciprocal relationship forms the basis of a negative ...
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ATM and Cellular Response to DNA Damage

2006
Most human cancers display a myriad of genetic changes, a characteristic often attributed to genome instability. Cytogenetic studies have long identified chromosomal aberrations as a hallmark of human tumours, but the causes and consequences of genomic defects in tumours still remain to be fully understood. In particular, the role of genome instability
Lavin, Martin F., Kozlov, Sergei, Gueven, Nuri, Peng, Cheng, Birrell, Geoff, Chen, Phillip, Scott, Shaun   +6 more
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The DNA damage response during DNA replication

Current Opinion in Cell Biology, 2005
Eukaryotic chromosome replication is mediated by multiple replicons and is coordinated with sister chromatid cohesion, DNA recombination, transcription and cell cycle progression. Replication forks stall or collapse at DNA lesions or problematic genomic regions, and these events have often been associated with recombination and chromosomal ...
M. Foiani, D. Branzei
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Checkpoint response to DNA damage

DNA Repair, 2009
M. Muzi-Falconi, J. Petrini
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The DNA Damage Response

2014
This chapter reviews the current knowledge about the mechanism of the LexA/RecA regulated response and its output in Escherichia coli, stressing newly emerging areas such as regulation of RecA filament formation and management of specialized DNA repair polymerases. It also talks about the SOS response in other bacterial species and its implications for
openaire   +1 more source

Functional interrogation of DNA damage response variants with base editing screens

Cell, 2021
Samuel B Hayward, Xiao Fan, Jen-Wei Huang   +2 more
exaly