Results 161 to 170 of about 7,534,152 (213)

Exosomal hnRNPA1‐delivered miR‐27a‐3p inhibits the radiation‐induced bystander effect in cervical cancer

Precision Radiation Oncology, Volume 10, Issue 3, Page 279-295, September 2026.
The study showed that TOMO‐mediated RIBE is activated by decreasing exosomal hnRNPA1 protein level and its capability to packaging miR‐27a‐3p. These new findings infer that hnRNPA1 is a novel inhibitor of RIBE, which potentiates to be a new therapeutic target for improving the efficacy of radiotherapy.
Meng‐Qi Yang, Ping Huang, Yun‐Rui Song, Yong‐Zhong Wu, Zheng Tang, Lu Zhang, Huan‐Li Luo, Yun‐Chang Liu, Dan Li, Fu Jin, Jiang‐Dong Sui, Ying Wang   +11 more
wiley   +1 more source

Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: From immune mechanisms to clinical practice

Precision Radiation Oncology, Volume 10, Issue 3, Page 371-387, September 2026.
RT‐immunotherapy synergy for thoracic tumors relies on precise target delineation to protect immune components. IFI, reduced volumes, and optimized positioning minimize damage, while multimodal imaging, DL, PBT, and FLASH‐RT enhance control. These innovations shift RT to an immune‐centric model, improving lung and esophageal cancer outcomes.
Xiaoying Chen, Minxiao Yi, Yu Deng, Qian Shen   +3 more
wiley   +1 more source

Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1‐Mediated DNA Damage Repair and PI3K/AKT Survival Signaling

Thoracic Cancer, Volume 17, Issue 18, September 2026.
Matrine simultaneously targets CHEK1 (impairing DNA repair, increasing γH2AX) and PI3K/AKT (activating mitochondrial apoptosis), reduced EMT, and strong in vitro and in vivo antitumor effects with low toxicity, positioning it as a promising dual‐mechanism agent for lung cancer.
Jianghao Yu, Siyang Chen, Tingting Hou, Xianwu Weng, Yakun Liu, Junchao Huang, Zeshan Yang, Jinyu Bao, Changshuai Zhou, Wanqing Lv, Qingzhe Wu, Yun Xu, Jinshan Zhou   +12 more
wiley   +1 more source

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

Aging Cell, Volume 25, Issue 9, September 2026.
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li, Zhen Yang, Wukaiyang Liang, Jie Huang, Tianyi Ji, Hao Nie, Zixin Wan, Yuqi Qiu, Yi Huang, Le Zhang, Cuntai Zhang, Jinhua Yan   +11 more
wiley   +1 more source

Timing‐Dependent Clearance of p16‐Positive Cells Mitigates Radiation‐Induced Accelerated Aging

Aging Cell, Volume 25, Issue 9, September 2026.
Genotoxic stress induces a progressive accelerated aging‐like phenotype driven by the delayed accumulation of p16Ink4a‐positive senescent cells. Selective clearance of these cells improves healthspan, tissue function, and survival only when initiated after senescent cells have accumulated, highlighting a critical therapeutic window for senescence ...
Karla Valdivieso, Melanie Weigand, Daniela G. Costa, Gung Lee, Nick Pirius, Helene Martini, Shivangi Oberai, Christina Inman, Yi Zhu, Thomas von Zglinicki, Sundeep Khosla, Nathan LeBrasseur, João F. Passos, Tamara Tchkonia, James L. Kirkland, Diana Jurk   +15 more
wiley   +1 more source

Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance

Aging Cell, Volume 25, Issue 9, September 2026.
Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative mode of telomere replication. ABSTRACT Cell division inevitably shortens telomeric DNA owing to the end‐replication problem.
Jie Wang, Yuehui Su, Chao Chen, Yueying Li, Jiajia Han, Liping Du, Liyun Zheng, Ya‐Long Dang, Ying Peng   +8 more
wiley   +1 more source

Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence

Aging Cell, Volume 25, Issue 9, September 2026.
Neuronal senescence‐like states arise from convergent intrinsic and disease‐associated stressors and are linked to persistent dysfunction, SASP‐like signaling, and altered glial interactions. Because no single marker is definitive in post‐mitotic neurons, multimarker and context‐dependent frameworks are required to define their role in ...
Miraj Ud Din Momand, Kristina Macova, Dominika Fricova   +2 more
wiley   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

A Spinal Cord Sarcoma With EWSR1::WT1 Fusion Exhibited Ewing Sarcoma‐Like Pattern Rather Than Desmoplastic Small Round Cell Tumor

Pathology International, Volume 76, Issue 9, September 2026.
We received a case of a 22 years old female, with a spinal cord sarcoma. The tumor consisted of small blue round cells, lack of desmoplastic stroma, with positive expression of CD99 and Desmin in IHC, negative expression of NKX2.2 in IHC, separative signals of EWSR1 gene probe in FISH, gene fusion of EWSR1(E9)::WT1(E8) through RNA and DNA NGS.
Chuqian Zeng, Yishan Wang
wiley   +1 more source