Results 181 to 190 of about 7,534,152 (213)

Breaking the DNA damage response to improve cervical cancer treatment

Cancer Treatment Reviews, 2016
Every year, cervical cancer affects similar to 500,000 women worldwide, and similar to 275,000 patients die of this disease. The addition of platin-based chemotherapy to primary radiotherapy has increased 5-year survival of advanced-stage cervical cancer
Marcel van Vugt
exaly   +2 more sources

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Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain

Journal of Molecular Neuroscience, 2011
Pronounced neuropathology is a feature of ataxia-telangiectasia (A-T) and Nijmegen breakage syndrome (NBS), which are both genomic instability syndromes. The Nbs1 protein, which is defective in NBS, is a component of the Mre11/RAD50/NBS1 (MRN) complex.
Michal, Kirshner, Ronit, Galron, Dan, Frenkel, Gil, Mandelbaum, Yosef, Shiloh, Zhao-Qi, Wang, Ari, Barzilai   +6 more
openaire   +2 more sources

Pathogenic variants in DNA damage response (DDR) genes in patients with advanced solid tumors.

Journal of Clinical Oncology, 2017
11567 Background: Deleterious mutations in DDR genes are frequently associated with response to poly(ADP-ribose) polymerase (PARP) inhibitors and platinum chemotherapy. However, much remains unknown about their association with specific molecular signaling pathways.
Ecaterina Elena Ileana Dumbrava, Lauren Brusco, Molly S Daniels, Chetna Wathoo, Kenna Rael Shaw, Karen H. Lu, Xiaofeng Zheng, Louise C. Strong, Jennifer Keating Litton, Banu Arun, Agda Karina Eterovic, Sarina Anne Piha-Paul, Vivek Subbiah, David S. Hong, Scott Eric Woodman, John Mendelsohn, Timothy Anthony Yap, Gordon B. Mills, Ken Chen, Funda Meric-Bernstam   +19 more
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Transcriptional regulation of DNA damage responsive (DDR) genes in different rad mutant strains of Saccharomyces cerevisiae

Molecular and General Genetics MGG, 1986
The roles of the RAD genes of Saccharomyces cerevisiae in the regulation of transcription of two DNA damage responsive (DDR) genes were investigated by examining the levels of the DDRA2 and DDR48 transcripts in different rad mutants after exposure to two different DNA damaging agents.
J A, Maga, T A, McClanahan, K, McEntee
openaire   +2 more sources

Evaluating DNA damage response (DDR) activation in human prostate cancer

2014
Introduction: Au Canada, le cancer de la prostate est le cancer le plus fréquemment diagnostiqué chez les hommes et le plus mortel après les cancers du poumon et du côlon. Il y a place à optimiser le traitement du cancer de la prostate de manière à mettre en œuvre une médecine personnalisée qui s’adapte aux caractéristiques de la maladie de chaque ...
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The interrelations between malfunctioning DNA damage response (DDR) and the functionality of the neuro-glio-vascular unit

DNA Repair, 2013
A hallmark of neurodegenerative diseases is impairment of certain aspects of "brain functionality". Brain functionality is defined as the total input and output of the brain's neural circuits and networks. A given brain degenerative disorder does not deregulate total brain functionality but rather the activity of specific circuits in a given network ...
openaire   +2 more sources

Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach

The Journal of Pharmacology and Experimental Therapeutics
Sulfur mustard (SM) is a highly reactive organic chemical has been used as a chemical warfare agent and terrorist threat since World War I. The cornea is highly sensitive to SM toxicity and exposure to low vapor doses can cause incapacitating acute injuries.
Robert Shalwitz, Tovah Day, Anna Kotsakis Ruehlmann, Lindsay Julio, Shellaina Gordon, Adrianna Vandeuren, Marian Nelson, Megan Lyman, Kyle Kelly, Amber Altvater, Celinia Ondeck, Sean O’Brien, Tracey Hamilton, Ryan L. Hanson, Kayla Wayman, Alexandrea Miller, Isaiah Shalwitz, Eric Batchelor, Patrick McNutt   +18 more
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Genomic landscape of defective DNA damage response and repair mechanisms (DDR) across cancer types.

Journal of Clinical Oncology, 2016
e23219Background: Genomic instability related to DDR defects leads to accumulation of somatic alterations that promote tumorigenesis, may confer sensitivity to platinum-based chemotherapy and may p...
MinYuen Teo, Emily Craig Zabor, Gopa Iyer, Richard Bambury, Mariel Elena Boyd, Jonathan E. Rosenberg   +5 more
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Research progress in DNA damage response (DDR)-targeting modulators: From hits to clinical candidates

European Journal of Medicinal Chemistry
In recent years, synthetic lethality has been regarded as a sound example of cancer treatment. Identifying a growing number of synthetic lethality targets has led to a substantial broadening of the application of synthetic lethality, well beyond the PAPR inhibitors employed for treating tumors with BRCA1/2 deficiencies.
Binbin Cheng, Zongbao Ding, Yimeng Hong, Yaping Wang, Yingxing Zhou, Jianjun Chen, Xiaopeng Peng, Chunlai Zeng   +7 more
openaire   +2 more sources

MA03.05 DNA Damage Response (DDR) Gene Mutations and Correlation With Immunotherapy Response in NSCLC Patients

Journal of Thoracic Oncology, 2021
J. Liu, H. Zhou, W. Ma, Y. Zhang, T. Zhou, Y. Yang, J. Huang, Y. Zhao, S. Hong, J. Zhan, H. Zhao, Y. Huang, W. Fang, L. Zhang   +13 more
openaire   +1 more source