Results 181 to 190 of about 106,021 (225)

Ubiquitin System-Driven Proteostasis in DNA Damage Response. [PDF]

Int J Mol Sci
Kusuma R, Valerie AR, Qin S, Ichiwa K, Joshua K, Seo G, Kim W.   +6 more
europepmc   +1 more source

Recent advances in DDR (DNA damage response) inhibitors for cancer therapy

European Journal of Medicinal Chemistry, 2022
DDR (DNA damage response) defects in cells drive tumor formation by promoting DNA mutations, which also provides cancer-specific vulnerabilities that can be targeted by synthetic lethality-based therapies. Until now, PARP inhibitors like olaparib are the first successful case of utilizing synthetic lethality-based therapy to treat cancers with DNA ...
Jianjun Chen, Xiao Yao, Wei Pan
exaly   +4 more sources

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Targeting the DNA damage response (DDR) by natural compounds

Bioorganic and Medicinal Chemistry, 2020
Natural compounds (NC) are an important source of anticancer drugs. The genomic DNA of tumor cells is a major target of conventional anticancer therapeutics (cAT). DNA damage elicits a complex stress response programme termed DNA damage response (DDR), with the PI3-like kinase ATM and ATR being the key regulators.
Jana, van Stuijvenberg, Peter, Proksch, Gerhard, Fritz   +2 more
exaly   +4 more sources

Development of a DNA damage response (DDR) therapeutics platform for oncology.

Journal of Clinical Oncology, 2021
e15036 Background: Cancer cells respond to increases in DNA damage by deploying their DNA damage response (DDR) pathways. We are building a platform for the discovery and development of target-specific DDR therapeutics, including small molecule inhibitors and targeted protein degradation warheads, founded on fragment- and structure-based drug ...
Debanu Das, Matthew Duncton, Patricia Pellicena, Ashley Deacon, David Wilson, Millie Georgiadis   +5 more
openaire   +2 more sources

Imaging DNA damage response (DDR) during oncogenesis

Cancer Research, 2016
Introduction: DNA damage repair (DDR) signalling is upregulated during tumorigenesis and acts as a p53-mediated block on proliferation. Expression of the DNA double strand break (DSB) repair protein, γH2AX, is induced by the activated kinases pATM or pATR during oncogenesis. Previously, we showed that γH2AX presents an abundant epitope for non-invasive
Cornelissen, B, Able, S, Kersemans, V, Vallis, K   +3 more
openaire   +2 more sources

Targeting mechanisms of the DNA damage response (DDR) by natural products

Planta Medica, 2019
JV Stuijvenberg, P Proksch, G Fritz
openaire   +2 more sources

DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac

Biochimica Et Biophysica Acta - Molecular Cell Research, 2013
Christian Henninger
exaly   +2 more sources

How Do Plants Cope with DNA Damage? A Concise Review on the DDR Pathway in Plants

International Journal of Molecular Sciences, 2023
DNA damage is induced by many factors, some of which naturally occur in the environment. Because of their sessile nature, plants are especially exposed to unfavorable conditions causing DNA damage. In response to this damage, the DDR (DNA damage response)
Iwona Szarejko, Miriam Szurman-Zubrzycka, Szurman-Zubrzycka Miriam   +2 more
exaly   +2 more sources

The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?

DNA Repair, 2021
Up to now, many improvements have been made in providing more therapeutic strategies for cancer patients. The lack of susceptibility to common therapies like chemo- and radio-therapy is one of the reasons why we need more methods in the field of cancer ...
Fatemeh Sadoughi, Liaosadat Mirsafaei, P. Dana, J. Hallajzadeh, Z. Asemi, M. Mansournia, M. Montazer, M. Hosseinpour, B. Yousefi   +8 more
semanticscholar   +1 more source