Results 201 to 210 of about 106,021 (225)

Genomic landscape of defective DNA damage response and repair mechanisms (DDR) across cancer types.

Journal of Clinical Oncology, 2016
e23219Background: Genomic instability related to DDR defects leads to accumulation of somatic alterations that promote tumorigenesis, may confer sensitivity to platinum-based chemotherapy and may p...
MinYuen Teo, Emily Craig Zabor, Gopa Iyer, Richard Bambury, Mariel Elena Boyd, Jonathan E. Rosenberg   +5 more
openaire   +1 more source

Research progress in DNA damage response (DDR)-targeting modulators: From hits to clinical candidates

European Journal of Medicinal Chemistry
In recent years, synthetic lethality has been regarded as a sound example of cancer treatment. Identifying a growing number of synthetic lethality targets has led to a substantial broadening of the application of synthetic lethality, well beyond the PAPR inhibitors employed for treating tumors with BRCA1/2 deficiencies.
Binbin Cheng, Zongbao Ding, Yimeng Hong, Yaping Wang, Yingxing Zhou, Jianjun Chen, Xiaopeng Peng, Chunlai Zeng   +7 more
openaire   +2 more sources

MA03.05 DNA Damage Response (DDR) Gene Mutations and Correlation With Immunotherapy Response in NSCLC Patients

Journal of Thoracic Oncology, 2021
J. Liu, H. Zhou, W. Ma, Y. Zhang, T. Zhou, Y. Yang, J. Huang, Y. Zhao, S. Hong, J. Zhan, H. Zhao, Y. Huang, W. Fang, L. Zhang   +13 more
openaire   +1 more source

Targeting DNA damage response pathways in cancer

Nature Reviews. Cancer, 2022
Florian J. Groelly, M. Fawkes, Rebecca A. Dagg, Andrew N. Blackford, M. Tarsounas   +4 more
semanticscholar   +1 more source

High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes

Genes, 2023
Menattallah Elserafy, Mohamed Gad, Sherif El-Khamisy   +2 more
exaly  

Genome wide profiling of miRNAs relevant to the DNA damage response induced by hexavalent chromium exposure (DDR-related miRNAs in response to Cr (VI) exposure)

Environment International, 2021
Yongran Cheng
exaly  

Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies

Cancers, 2021
Katia Cailliau, Alain Martoriati, Caroline Molinaro   +2 more
exaly  

Therapeutic opportunities within the DNA damage response

Nature Reviews Cancer, 2015
Laurence Pearl, Frances Pearl, Simon E Ward   +2 more
exaly  

Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer

Nature Reviews Cancer, 2012
Raffaella Di Micco, Fabrizio D'Adda Di Fagagna, Di Micco Raffaella   +2 more
exaly  

To control or to be controlled? Dual roles of CDK2 in DNA damage and DNA damage response

DNA Repair, 2020
Fei Shen, Yang Luo, Chenyang Zhao
exaly