Results 191 to 200 of about 106,021 (225)

Interactome Profiling of DNA Damage Response (DDR) Mediators with Immunoprecipitation-Mass Spectrometry

2023
Immunoprecipitation-mass spectrometry (IP-MS) is a versatile tool to probe for global protein-protein interactions (PPIs) in biological samples. Such interactions coordinate complex biological processes, such as the DNA damage response (DDR). Induction of DNA damage activates signaling networks where posttranslational modifications cause PPI that ...
Henry C-H, Law, Dragana, Noe, Nicholas T, Woods   +2 more
openaire   +2 more sources

The landscape of DNA damage response (DDR) pathway in colorectal cancer (CRC).

Journal of Clinical Oncology, 2020
4064 Background: Abnormal DDR is a hallmark of cancer, relating to genome instability, anti-tumor immunity, and sensitivity to chemotherapeutic agents and radiation. We conducted a large-scale investigation to clarify the alteration of DDR pathway in CRC. Methods: Tumor samples from 9321 CRC patients were retrospectively reviewed.
Hiroyuki Arai, Andrew Elliott, Jingyuan Wang, Francesca Battaglin, Shivani Soni, Wu Zhang, Davendra Sohal, Richard M. Goldberg, Michael J. Hall, Aaron James Scott, Mohd Khushman, Jimmy J. Hwang, Emil Lou, Benjamin A. Weinberg, John Marshall, Albert Craig Lockhart, Phillip Stafford, Jian Zhang, W. Michael Korn, Heinz-Josef Lenz   +19 more
openaire   +1 more source

Combination DNA Damage Response (DDR) Inhibitors to Overcome Drug Resistance in Ovarian Cancer

2023
The DNA damage response (DDR) results in activation of a series of key target kinases that respond to different DNA damage insults. DDR inhibitors such as PARP inhibitors lead to the accumulation of DNA damage in tumor cells and ultimately apoptosis. However, responses to DDRi monotherapy in the clinic are not durable and resistance ultimately develops.
Dimitrios, Nasioudis, Erin M, George, Haineng, Xu, Hyoung, Kim, Fiona, Simpkins   +4 more
openaire   +2 more sources

Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain

Journal of Molecular Neuroscience, 2011
Pronounced neuropathology is a feature of ataxia-telangiectasia (A-T) and Nijmegen breakage syndrome (NBS), which are both genomic instability syndromes. The Nbs1 protein, which is defective in NBS, is a component of the Mre11/RAD50/NBS1 (MRN) complex.
Michal, Kirshner, Ronit, Galron, Dan, Frenkel, Gil, Mandelbaum, Yosef, Shiloh, Zhao-Qi, Wang, Ari, Barzilai   +6 more
openaire   +2 more sources

Pathogenic variants in DNA damage response (DDR) genes in patients with advanced solid tumors.

Journal of Clinical Oncology, 2017
11567 Background: Deleterious mutations in DDR genes are frequently associated with response to poly(ADP-ribose) polymerase (PARP) inhibitors and platinum chemotherapy. However, much remains unknown about their association with specific molecular signaling pathways.
Ecaterina Elena Ileana Dumbrava, Lauren Brusco, Molly S Daniels, Chetna Wathoo, Kenna Rael Shaw, Karen H. Lu, Xiaofeng Zheng, Louise C. Strong, Jennifer Keating Litton, Banu Arun, Agda Karina Eterovic, Sarina Anne Piha-Paul, Vivek Subbiah, David S. Hong, Scott Eric Woodman, John Mendelsohn, Timothy Anthony Yap, Gordon B. Mills, Ken Chen, Funda Meric-Bernstam   +19 more
openaire   +1 more source

Transcriptional regulation of DNA damage responsive (DDR) genes in different rad mutant strains of Saccharomyces cerevisiae

Molecular and General Genetics MGG, 1986
The roles of the RAD genes of Saccharomyces cerevisiae in the regulation of transcription of two DNA damage responsive (DDR) genes were investigated by examining the levels of the DDRA2 and DDR48 transcripts in different rad mutants after exposure to two different DNA damaging agents.
J A, Maga, T A, McClanahan, K, McEntee
openaire   +2 more sources

Histone Phosphorylation in DNA Damage Response

International Journal of Molecular Sciences
The DNA damage response (DDR) is crucial for maintaining genomic stability and preventing the accumulation of mutations that can lead to various diseases, including cancer. The DDR is a complex cellular regulatory network that involves DNA damage sensing,
P. Gong, Zhaohui Guo, Shengping Wang, Shufeng Gao, Qinhong Cao   +4 more
semanticscholar   +1 more source

Evaluating DNA damage response (DDR) activation in human prostate cancer

2014
Introduction: Au Canada, le cancer de la prostate est le cancer le plus fréquemment diagnostiqué chez les hommes et le plus mortel après les cancers du poumon et du côlon. Il y a place à optimiser le traitement du cancer de la prostate de manière à mettre en œuvre une médecine personnalisée qui s’adapte aux caractéristiques de la maladie de chaque ...
openaire   +1 more source

Advancing cancer therapy: new frontiers in targeting DNA damage response

Frontiers in Pharmacology
Genomic instability is a core characteristic of cancer, often stemming from defects in DNA damage response (DDR) or increased replication stress. DDR defects can lead to significant genetic alterations, including changes in gene copy numbers, gene ...
Jiekun Qian, Guoliang Liao, Maohui Chen, Ren-Wang Peng, Xin Yan, Jianting Du, Renjie Huang, Maojie Pan, Yuxing Lin, Xian Gong, Guo-bing Xu, Bin Zheng, Chun Chen, Zhang Yang   +13 more
semanticscholar   +1 more source

The interrelations between malfunctioning DNA damage response (DDR) and the functionality of the neuro-glio-vascular unit

DNA Repair, 2013
A hallmark of neurodegenerative diseases is impairment of certain aspects of "brain functionality". Brain functionality is defined as the total input and output of the brain's neural circuits and networks. A given brain degenerative disorder does not deregulate total brain functionality but rather the activity of specific circuits in a given network ...
openaire   +2 more sources