Results 11 to 20 of about 96,036 (271)
GADD45A does not promote DNA demethylation.
PLoS Genetics, 2008 Although DNA methylation patterns in somatic cells are thought to be relatively stable, they undergo dramatic changes during embryonic development, gametogenesis, and during malignant transformation.
Seung-Gi Jin, Cai Guo, Gerd P Pfeifer
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Reprogramming of fibroblast cells to totipotent state by DNA demethylation [PDF]
Scientific Reports, 2023 Many attempts have been made to induce high-quality embryonic stem cells such as pluripotent stem cells and totipotent stem cells, but challenges remain to be overcome such as appropriate methods and sources.
Mohammad H. Ghazimoradi +4 more
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The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients [PDF]
Scientific ReportsThe active DNA demethylation process, which involves TET proteins, can affect DNA methylation pattern. TET dependent demethylation results in DNA hypomethylation by oxidation 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) and its derivatives.
Kinga Linowiecka +13 more
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Gadd45a promotes DNA demethylation through TDG [PDF]
Nucleic Acids Research, 2017 Growth arrest and DNA-damage-inducible protein 45 (Gadd45) family members have been implicated in DNA demethylation in vertebrates. However, it remained unclear how they contribute to the demethylation process.
Gu, Tian-Peng +12 more
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Vitamin C and MEK Inhibitor PD0325901 Synergistically Promote Oligodendrocytes Generation by Promoting DNA Demethylation [PDF]
MoleculesDNA methylation and demethylation are key epigenetic events that regulate gene expression and cell fate. DNA demethylation via oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) is typically mediated by TET (ten-eleven translocation ...
Xinyue Ren +5 more
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Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation [PDF]
Nature CommunicationsThe intracellular ATP-ribosyltransferases PARP1 and PARP2, contribute to DNA base excision repair (BER) and DNA demethylation and have been implicated in epigenetic programming in early mammalian development.
Simon D. Schwarz +9 more
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Active DNA demethylation damages DNA. [PDF]
Science, 2022 Active DNA demethylation maintains enhancer activity in nonproliferating cells but can damage ...
López-Moyado IF, Rao A.
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Proceedings of the National Academy of Sciences, 1999 Cytosine 5′ methylation of CpG dinucleotides within and around genes exerts a major influence on transcription in many plants and animals (1–3). DNA methylation can be causal for transcriptional silencing (4–5) and targets the machinery necessary to assemble specialized chromatin enriched in deacetylated histones (6–8).
A P, Wolffe, P L, Jones, P A, Wade
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DNA Demethylation Dynamics [PDF]
Cell, 2011 The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of demethylating DNA and activating genes. Further experiments, however, unearthed an unexpectedly complex process, entailing both passive and active mechanisms of DNA demethylation by the ten-eleven translocation (TET) and AID/APOBEC families of enzymes.
Bhutani, Nidhi +2 more
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DNA demethylation by DNA repair [PDF]
Trends in Genetics, 2009 Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process.
Gehring, Mary +2 more
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