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Demethylation of repetitive DNA sequences in neuroblastoma

Genes, Chromosomes and Cancer, 1996
Altered genomic methylcytosine content has been described for a number of tumor types, including neuroblastoma. However, it remains to be determined for different tumor types whether specific loci or chromosomal regions are affected by a methylation change or whether the change is random.
D, Thoraval +8 more
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Replication and Demethylation of O6-Methylguanine in DNA

1983
Publisher Summary To study the disappearance and the effect upon DNA replication of O 6 -methylguanine in vitro , this chapter presents the synthesis of polydeoxynucleotides containing O 6 -methylguanine to be used as substrates for “repair enzymes” and as templates for DNA polymerases.
E T, Snow, R S, Foote, S, Mitra
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DNA demethylation and cancer: therapeutic implications

Cancer Letters, 2004
The epigenome, which is comprised of chromatin and its associated proteins and the patterns of covalent modification of DNA by methylation, sets up and maintains gene expression programs. A hallmark of cancer is a paradoxical aberration of DNA methylation patterns, a global loss of DNA methylation, that coexists with regional hypermethylation of ...
Moshe, Szyf, Pouya, Pakneshan, Shafaat A, Rabbani +2 more
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DNA Demethylating Agents